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Yaqiong Chen#, Jiang Wang#, Yibing Wang, Pengfei Wang, Zan Zhou, Rong Wu, Qian Xu, Hanyun You, Yaxin Liu, Lei Wang, Lingqin Zhou, Yuting Wu, Lihong Hu*, Hong Liu* and Yi Liu*. A Propolis-Derived Small Molecule Ameliorates Metabolic Syndrome in Obese Mice by Targeting the CREB/CRTC2 Transcriptional Complex. Nature Communications, 2022, 13, 246-265.
Jiang Wang#, Jing Zhao#, Cong Yan#, Cong Xi#, Chenglin Wu, Jingxiang Zhao, Fengwei Li, Yanhua Ding, Rui Zhang, Shankang Qi, Xingjun Li, Chao Liu, Wanting Hou, Hong Chen, Yiping Wang, Dalei Wu, Kaixian Chen, Hualiang Jiang, He Huang*, and Hong Liu*. Identification and evaluation of a lipid-lowering small compound in preclinical models and in a Phase I trial. Cell Metabolism, 2022, 34, 667-680.
Daqing Fang#, Xidan Wen#, Yuqi Wang, Yidan Sun, Ruibing An, Yu Zhou, Deju Ye*, Hong Liu*. Engineering of donor-acceptor-donor curcumin analogues as near-infrared fluorescent probes for in vivo imaging of amyloid-β species. Theranostics, 2022, 12, 3178-3195.
Chunpu Li#, Mingbo Su#, Wei Zhu#, Weijuan Kan, Tianpeng Ge, Gaoya Xu, Shuni Wang, Li Sheng, Feng Gao, Yunfei Ye, Jiang Wang, Yubo Zhou*, Jia Li* and Hong Liu*. Structure？Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors. Journal of Medicinal Chemistry, 2022, 65, 4335-4349.
Feifei Fang, Shulei Hu, Chunpu Li, Qian Wang, Run Wang, Xu Han, Yu Zhou* and Hong Liu*. Catalytic System-Controlled Divergent Reaction Strategies for the Construction of Diversified Spiropyrazolone Skeletons from Pyrazolidinones and Diazopyrazolones. Angewandte Chemie International Edition, 2021, 60, 21327-21333.
Xiaohui Wei#, Xuewu Liang#, Yazhou Li, Qi Liu, Xuyi Liu, Yu Zhou* and Hong Liu*. I2-induced cascade cyclization and dearomatization of indoles for the highly efficient synthesis of iodinated and vinylic spiroindolenines. Green Chemistry, 2021, 23, 9165-9171.
Xu Han#, Ning Song#, Abdusaid Saidahmatov, Peipei Wang, Yong Wang, Xiaobei Hu, Weijuan Kan, Wei Zhu, Lixin Gao, Mingjie Zeng, Yujie Wang, Chunpu Li, Jia Li, Hong Liu*, Yubo Zhou* and Jiang Wang*. Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia. Journal of Medicinal Chemistry, 2021, 64, 14647-14663.
Wenhao Dai#, Dirk Jochmans#, Hang Xie#, Hang Yang#, Jian Li, Haixia Su, Di Chang, Jiang Wang, Jingjing Peng, Lili Zhu, Yong Nian, Rolf Hilgenfeld, Hualiang Jiang, Kaixian Chen, Leike Zhang*, Yechun Xu*, Johan Neyts* and Hong Liu*. Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV？2. Journal of Medicinal Chemistry, 2022, 65, 2794-2808.
Guoxue He#, Jinyu Ma#, Jianhui Zhou, Chunpu Li, Hong Liu* and Yu Zhou*. A metal-free method for the facile synthesis of indanones via the intramolecular hydroacylation of 2-vinylbenzaldehyde. Green Chemistry, 2021, 23, 1036-1040.
Xiaowei Wu#, Mengdi Dai#, Rongrong Cui#, Yulan Wang, Chunpu Li, Xia Peng, Jihui Zhao, Bao Wang, Yang Dai, Dan Feng, Tianbiao Yang, Hualiang Jiang, Meiyu Geng, Jing Ai*, Mingyue Zheng*, Hong Liu*. Design, Synthesis and Biological Evaluation of Pyrazolo[3,4-d]pyridazinone Derivatives as Covalent FGFR Inhibitors. Acta Pharmaceutica Sinica B, 2021, 11, 781-794.
Xuewu Liang#, Chenxia Sun#, Chunpu Li#, Haolan Yu#, Xiaohui Wei, Xuyi Liu, Wei Bao, Yuqiang Shi, Xiaochen Sun, Mirzadavlat Khamrakulov, Chenghua Yang* and Hong Liu*. Identification of Novel Fused Heteroaromatics-Based MALT1 Inhibitors by High-Throughput Screening to Treat B Cell Lymphoma. Journal of Medicinal Chemistry, 2021, 64, 9217-9237.
Wenhao Dai#, Bing Zhang#, Xia-Ming Jiang#, Haixia Su#, Jian Li, Yao Zhao, Xiong Xie, Zhenming Jin, Jingjing Peng, Fengjiang Liu, Chunpu Li, You Li, Fang Bai, Haofeng Wang, Xi Cheng, Xiaobo Cen, Shulei Hu, Xiuna Yang, Jiang Wang, Xiang Liu, Gengfu Xiao, Hualiang Jiang, Zihe Rao, Lei-Ke Zhang*, Yechun Xu*, Haitao Yang*, Hong Liu*. Structure-Based Design of Antiviral Drug Candidates Targeting the SARS-CoV-2 Main Protease. Science, 2020, 368, 1331-1335.
Yichu Liu, Yibing Wang, Wenhao Dai, Wei Huang, Yingxia Li* and Hong Liu*. Palladium-Catalysed C(sp3)-H Glycosylation for Synthesis of C-Alkyl Glycoamino Acids. Angewandte Chemie International Edition, 2020, 59, 3491-3494.
Xingjun Li#, Jiang Wang#, Xiong Xie, Wenhao Dai, Xu Han, Kaixian Chen* and Hong Liu*. Ir(III)-Catalyzed direct C-H functionalization of N-phenylacetamide with α-diazo quinones: a novel strategy for producing 2-hydroxy-2’amino-1,2’-biaryl scaffolds. Chemical Communications, 2020, 56, 3441-3444.
Jingjing Peng, Chunpu Li, Mirzadavlat Khamrakulov, Jiang Wang* and Hong Liu*. Rhodium(III)-Catalyzed C？H Alkenylation: Access to Maleimide-Decorated Tryptophan and Tryptophan-Containing Peptides. Organic Letters, 2020, 22, 1535-1541.
Junyou Li#, Mengqi Liu#, Yazhou Li, Dan-dan Sun, Zhihao Shu, Qian Tan, Shimeng Guo, Rongrong Xie, Lixin Gao, Hongbo Ru, Yi Zang, Hong Liu, Jia Li*, and Yu Zhou*. Discovery and Optimization of Non-bile Acid FXR Agonists as Preclinical Candidates for the Treatment of Nonalcoholic Steatohepatitis. Journal of Medicinal Chemistry, 2020, 63, 12748-12772.
Chenglin Wu#, Cong Xi#, Junhua Tong, Jing Zhao, Hualiang Jiang, Jiang Wang*, Yiping Wang* and Hong Liu*. Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators for the treatment of hyperlipidemia. Acta Pharmaceutica Sinica B, 2019, 9, 1216-1230.
Xuewu Liang, Jie Zang, Xiaoyang Li, Shuai Tang, Min Huang, Meiyu Geng, C. James Chou, Chunpu Li, Yichun Cao, Wenfang Xu, Hong Liu* and Yingjie Zhang*. Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies. Journal of Medicinal Chemistry, 2019, 62, 3898-3923.
Panfeng Peng#, Huan Chen#, Ya Zhu#, Zhilong Wang#, Jian Li, Rong-Hua Luo, Jiang Wang, Liang Chen, Liu-Meng Yang, Hualiang Jiang, Xin Xie, Beili Wu*, Yong-Tang Zheng* and Hong Liu*. Structure -Based Design of 1？Heteroaryl-1,3-propanediamine Derivatives as a Novel Series of CC-Chemokine Receptor 5 Antagonists. Journal of Medicinal Chemistry, 2018, 61, 9621-9636.
Feifei Fang, Chunmei Zhang, Chaofan Zhou, Yazhou Li, Yu Zhou* and Hong Liu*. Rh(III)-Catalyzed C？H Activation of Benzoylacetonitriles and Tandem Cyclization with Diazo Compounds to Substituted Benzo[de]chromenes. Organic letters, 2018, 20, 1720-1724.
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