丁侃 - 中国科学院上海药物研究所 -

研究领域

目前主要致力于细胞膜蛋白聚糖在疾病中结构和功能相关机制研究，在此基础上发现糖类药物的新靶标分子。目前研究内容包括：多糖结构解析、聚糖-蛋白相互作用、中药多糖生物活性筛选、构效关系研究、多糖吸收机制研究。此外，还致力研究： 1.细胞膜硫酸乙酰肝素蛋白聚糖糖链合成酶和降解酶在诸如肿瘤和神经系统疾病发展中的功能机制； 2.聚糖介导的microRNA在肿瘤血管生成中的功能机制； 3.抗肿瘤中药多糖结构靶向性及其功能机制研究。

近期论文

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Li J, Fang J, Qin Y, Liao W, Liu H, Zhou Y*, Ding K*. Glce regulates PC12 cell neuritogenesis induced by nerve growth factor through activating Smad/Id3 signaling. Biochem J. 2014, 459(2): 405-416 (*Corresponding author) Xiao F, Qiu H, Cui H, Ni X, Li J, Liao W, Lu N, Ding K*. MicroRNA-885-3p inhibits the growth of HT-29 colon cancer cell xenografts by disrupting angiogenesis via targeting BMPR1A and blocking BMP/Smad/Id1 signaling. Oncogene, 2014, Jun 2;0. doi: 10.1038/onc.2014.134. Liu H, Zhou L, Shi S, Wang Y, Ni X, Xiao F, Wang S, Li P* Ding K*. Oligosaccharide G19 inhibits U-87 MG human glioma cells growth in vitro and in vivo by targeting epidermal growth factor (EGF) and activating p53/p21 signaling. Glycobiology, 2014 May 5. pii: cwu038. [Epub ahead of print]. Cong Q, Shang M, Dong Q*, Liao W, Xiao F, Ding K*. Structure and activities of a novel heteroxylan from Cassia obtusifolia seeds and its sulfated derivative. Carbohydr Res. 2014; 393C:43-50 Cong Q, Xiao F, Liao W, Dong Q*, Ding K*. Structure and biological activities of an alginate from Sargassum fusiforme, and its sulfated derivative. Int J Biol Macromol. 2014, May 28. pii: S0141-8130(14)00352-3. doi: 10.1016/j.ijbiomac.2014.05.056. Wang P, Liao W, Fang J, Liu Q, Yao J, Hu M, Ding K*. A glucan isolated from flowers of Lonicera japonica Thunb. inhibits aggregation and neurotoxicity of Aβ42. Carbohydr. Polym. 2014, 110C:142-147 Wang Y, Shen X, Liao W, Fang J, Chen X, Dong Q, Ding K*. A heteropolysaccharide, l-fuco-d-manno-1,6-d-galactan extracted from Grifola frondosa and antiangiogenic activity of its sulfated derivative. Carbohydr Polym. 2014, 101: 631-41 Shi L*, Dong Q, Ding K*. Structure elucidation and immunomodulatory activity in vitro of a xylan from roots of Cudrania tricuspidata. 2014，Food Chem. 152：291-296 Peipei Wang, Kan Ding*. Proteoglycans and Glycosaminoglycans in Misfolded Proteins Formation in Alzheimer’s Disease. Protein Pept. Lett. 2014, (Reference #: K_DING_PPL_ Manuscript_20130610, in press) Wang Y, Fang J, Ni X, Li J, Liu Q, Dong Q, Duan J*, Ding K*. Inducement of Cytokine Release by GFPBW2, a Novel Polysaccharide from Fruit Bodies of Grifola frondosa, through Dectin-1 in Macrophages. J Agric Food Chem. 2013, 61(47):11400-9 Xiao F, Qiu H, Zhou L, Shen X, Yang L, Ding K*. WSS25 inhibits Dicer, downregulating microRNA-210 which targets Ephrin-A3, to suppress human microvascular endothelial cell (HMEC-1) tube formation. Glycobiology. 2013, 23(5):524-35 Zhang, X Liao, W Cong, Q Dong, Q* Ding, K*. Isolation and structural characterization of the polysaccharides of cortex mori radices. Acta Chimica Sinica, 2013, DOI:10.6023/A13010109 Feng C, Li J, Ruan J, Ding K*. MicroRNA-125a inhibits cell growth by targeting glypican-4. Glycoconj J. 2012, 29(7):503-11 Shang M, Zhang X, Dong Q,* Yao J, Liu Q, Ding K* Isolation and structural characterization of the water-extractable polysaccharides from Cassia obtusifolia seeds. Carbohydr. Polym, 2012, 90(2):827-32 Liu Y, Fang J, Cai H, Xiao F, Ding K*, Hu Y*. Identification and synthesis of substituted pyrrolo[2,3-d]pyrimidines as novel firefly luciferase inhibitors. Bioorg Med Chem. 2012, 20(18):5473-82. Chen X, Xiao F, Wang Y, Fang J, Ding K* Structure-activity relationship study of WSS25 derivatives with anti-angiogenesis effects. Glycoconj J. 2012, 29(5-6):389-98 Fang J, Wang Y, Lv X, Shen X, Ni X, Ding K*. Structure of a β-glucan from Grifola frondosa and its antitumor effect by activating Dectin-1/Syk/NF-κB signaling. Glycoconj J. 2012, 29(5-6): 365-77 Fang JP, Liu Y, Li J, Liao WF, Hu YH*, Ding K*.A novel small molecule, HK-156, inhibits lipopolysaccharide-induced activation of NF-κB signaling and improves survival in mouse models of sepsis. Acta Pharmacol Sin. 2012, 33(9):1204-16 Lv XF, Chen SH, Li J, Fang JP, Guo YW*, Ding K*. Lobolide, a diterpene, blockades the NF-κB pathway and p38 and ERK MAPK activity in macrophages in vitro. Acta Pharmacol Sin. 2012, 33(10):1293-300 Dong Q, Wang Y, Shi L, Yao J, Li J, Ma F, Ding K *. A novel water-soluble β-D-glucan isolated from the spores of Ganoderma lucidum. Carbohydr Res. 2012, 353:100-5