研究领域
以纳米材料和微纳制造为纽带将现代理化科技与前沿生物医学和信息等学科交叉,开展“医工信能纺” 融合创新。 (1)集成智能程序微流体制备微系统可控合成磁、光、电和生物功能材料,开展其在能源催化、个性智能医药(抗癌药)和诊疗保健织物上的应用。 (2)发展原子精度上可控制备纳米结构薄膜和2D材料新技术,研究其拓扑结构、界面磁电耦合、自旋-轨道耦合和逆霍尔效应等物理机制,构建柔性通讯器件和生化传感器; (3)构建物理场和前线药物(纳米药物、基因和免疫药物)联合疗法液滴微流体实验平台,开发原始创新型联合疗法
专利:
1. 宋玉军,宋文琦,等,一种具有自主靶向和影像功能的纳米合金抗癌药物及其制备方法,中国发明专利批准号:ZL201510395518.4, 2018.10.09;
2. 宋玉军,张伟伟,一种超纯石英砂的制备方法,中国发明专利批准号:ZL201710230116.8, 2019.07.12;
3. 宋玉军、张伟伟,一种以高岭土尾矿为原料获取铷盐的方法,中国发明专利批准号:ZL201610409513.7, 2017.12.22;
4.宋玉军,王俊美,一种多棱角梯度结构纳米催化剂及其制备方法, 中国发明专利批准号:ZL 201510874685.7;
5. 宋玉军等,一种批量制备石墨烯和掺杂石墨烯的方法,中国发明专利批准号: ZL 201510334460.2;
6. 宋玉军,一种高纯连通型多孔氧化物粉体的制备方法,中国发明专利批准号:ZL 201510873049.2;
7. 宋玉军、王延等,界面作用诱导自组装高密度纳米阵列的方法,2016.08.24,中国,ZL2013 10470363.7;
8.宋玉军、季韶霞等,一种超小核壳纳米颗粒及其制备方法,2016.08.24,中国,ZL2013 10446082.8;
9.宋玉军、李再道、王振清,一种多功能高效管式加热装置,2015.03.25,中国,ZL201310194011.3;
10.宋玉军,一种非晶纳米晶梯度功能材料及其制备方法,2013.01.30,中国,ZL201110298237.9;
11.宋玉军,一种纳米压印用模板的制备及其应用,2014.11.12,中国,ZL201110404116.8;
12.宋玉军,单个纳米颗粒及其阵列基生物分子检测器的制备工艺,2012.12.05,中国,ZL200910085973.9;
13.宋玉军、李润生,一种非晶态核壳纳米颗粒及其制备方法,2013.10.30,中国,ZL201210011820.1;
14.宋玉军,用于纳米颗粒可控制备的微流体反应器及颗粒的制备工艺,2011.12.21,中国,ZL200910085974.3;
15.宋玉军,一种铁氧体纳米颗粒的制备方法,2013.03.27,中国,ZL201110102232.4;
16.宋玉军、王荣明、宋源军,纳米氧化钨的水溶液制备方法及其应用,2016.04.27,中国,ZL201410566844.2;
17.宋玉军、孙强强,一种多层复合丝旋转制备装置及其制备方法,2012.01.11,中国,ZL201010262287.7;
18.宋玉军,一种多层次非晶合金基微结构的制备方法,2011.11.16,中国,ZL201010290499.6;
19.宋玉军、张涛,一种非晶态合金基光学聚焦镜及其制备方法,2013.01.30,中国,ZL201110004924.5;
20.宋玉军、孙绍强、张涛,一种超弥散纳米结构合金钢及其制备工艺,2012.03.21,中国,ZL2010 10222431.4;
21.宋玉军,一种聚羧酸系减水剂复配剂的制备方法,2013.06.19,中国,ZL2011 10102226.9;
22.宋玉军,一种钛白粉生长过程中产生的酸性污水的综合治理方法,2013.01.30,中国,ZL201110260768.9;
23.宋玉军、吴勇,造纸黑液中提取木质素的方法,2011.01.26,中国,ZL200910077742.3;
24.宋玉军,羧基化木质素的制备方法,2012.08.15,中国,ZL 201010159677.1;
25.孙德荣、李帅、宋玉军等,一种非晶纳米晶改性涤纶自洁屏蔽纤维制备方法,2015.09.02,中国,ZL201310291371.5;
26.孙德荣、蒋士成、吴卫东、宋玉军等,一种用于生产一步法双收缩复合纤维的纺丝与卷绕联合装置,2014.10.01,中国,ZL201010597173.8;
27.孙德荣、吴卫东、宋玉军等,一种用于生产一步法双组份异收缩超细旦混纤长丝的生产装置,2011.06.15,中国,ZL201020626766.8
科研项目代表:
1、国家自然科学基金面上项目,具有多重刺激响应和多模成像功能口服型肝癌纳米药物结构设计和制备及药理研究,2020/01-2023/12,51971029,60万,在研,主持。
2、国家自然科学基金国际(地区)合作与交流项目(NSFC- BRICS(国际组织)):具有高磁光效应和自旋-轨道相互作用的纳米结构,2019/01-2021/12,51862245309,160万,在研,主持
3、国家科技重大专项:原始创新型纳秒刀精准消融肝癌抗复发转移的研发及临床应用研究(2018/01-2020/12,SQ2018ZX100301,1636.66万),四、纳秒脉冲联合纳米药物精准消融肝癌及其机制研究,子课题主持。
4、企业产学研合作项目(杭州睿迪),高灵敏磁光生物分子传感器试验样机的研制, 2019/08-2021/08, 55 万,在研,主持。
5、福建“省百人”创新人才基金,高纯二氧化硅复合材料的产业化应用研究,2017/03-2019/03,100万,在研,主持
6、厦门“双百”人才基金,高纯二氧化硅砂及其功能粉体的绿色制备工艺及产业化应用,2016/10-2019/09,160万,在研,主持
7、国家自然科学基金面上项目,51371018,模板转印法制备磁等离子体纳米材料及界面磁电耦合对其磁光特性互动的作用机制,2014/01-2017/12,80万,结题,主持
8、国家自然科学基金面上项目,50971010,程序变温微流体法制备核壳结构型纳米材料, 2010/01-2012/12,40万,结题,主持
9、江苏省双创人才计划,具有自清洁和电磁屏蔽功能的涤纶丝研制,项目经费号:54-0673,2011/01-2013/12,100万,结题,主持
10、国家重大基础科研973项目,2007CB613900,高性能轻质非晶合金的若干关键基础问题研究,2007/01-2011/12,2900万,结题,参加
11、美国NIH生物医学纳米专项,R01GM076440,纳米生物分子探针对生物分子跨膜输运机理的表征研究,2005/08-2007/09 (2005-2010),$3.50M (M: 百万),结题,参加
12、美国NSF纳米生物专项, NSF-NIRT(BES 0507036),纳米光学生物分子探针的设计和制备,2005/08-2007/09 (2005-2010),$1.09M,结题,参加
13、美国NSF项目,NSF-EPSCoR (Grant No. NSF/LEQSF(2001-04)RII-03),纳米磁性颗粒的微流体制备及在乳腺癌诊疗上的应用,2001-2004,$0.80M,结题,参加
14、美国DARPA纳米生物武器检测专项,Grant HR0011-04-C-0068,GMR生物分子传感器的研制,2002/06-2005/05,$2.40M,结题,参加
近期论文
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专著(章节):
(1)Y Song*(主编), D Cheng, L Zhao, “Microfluidics: Fundamentals, Devices and Applications”, Wiley-VCH, ISBN:9783527341061 (hard copy), 9783527800643 (online), Feb 8, 2018;
(2)Y Song (主编), “Inorganic and Organic Thin Films:Fundamentals, Fabrication and Applications”, Wiley-VCH, 在编;
(3)Y Song, “Controlled Fabrication of Noble Metal Nanomaterials via Nanosphere Lithography and Their Optical properties”,IN-TECH, Jan, 2011;
(4)3 X-H N Xu*, Y Song and P Nallathamby, “Probing Membrane Transport of Single Live Cells using Single Molecule Detection and Single Nanoparticle Assay”,John Wiley & Son, Inc., 2007
近期及代表性论文:
(1)Z Ren, X Chen, L Hong, G Cui,Y Liu, A Li, X Zhao,L Zhou, R Sun, J Li, J Wang, G Xu, Z Yu*, Y Song*, X Chen*, Nanoparticles Conjugating Ginsenoside Rg3 Inhibit Hepatocellular Carcinoma Developmentvia the Correction of Unbalanced Gut Microbiota and Metabolism. Small, under reviewing.
(2) J Ma, X Tong, J Wang, G Zhang, Y Lv, Y Zhu,S Sun, Yung-Chin Yang, Y Song*, Rare-earth metal oxide hybridized PtFe nanocrystals synthesized viamicrofluidic process for enhanced electrochemical catalyticperformance. Electrochimica Acta 2019, 299, 80-88.
(3)W Zhang, Q Wang, C Zhao, Y Song,∗The optical cavity enhanced magneto-optical Kerr effect signals of AAO/Al-based CoFeB nanostructure arrays. Optics Communications 2019, 437 44–49.
(4) W Zhang, Y Wang, QWang, V I. Belotelov, Y Song*, Surface and Interface Engineering Multilayered Nanopore Films forEnhanced Fabry−Pérot Interferences. J Phys Chem C 2018, 122, 29457−29463.
(5) D O. Ignatyeva, A N. Kalish , V Gopal Achanta, Y Song, VI. Belotelov, A K. Zvezdin, Control of Surface Plasmon-Polaritonsin Magnetoelectric Heterostructures. Journal of Lightwave Technology 2018, 36(13), .2660-2666.
(6) J Wang, H Ye, Y Song*, In-situ Reaction-Growth of PtNiX Nanocrystals on Supports for Enhanced Electrochemical Catalytic Oxidation of Ethanol via Continuous Flow Microfluidic Process. Electrochimica Acta2018, 278, 149-155.
(7) W Zhang, Z Liu, V I. Belotelovb, Q Wangd, Y Song*, The magnetic properties of CoFeB and CoFeB/Ag nanodot arrays fabricatedby a template transfer imprinting method. Thin Solid Films 2018, 660, 301–305.
(8)X Zhao, J Wang, Y Song*, X Chen, Synthesis of Nanomedicines by Nanohybrids Conjugating Ginsenosides with Auto-Targeting and Enhanced MRI Contrast for Liver Cancer Therapy. Drug Dev Ind Pharm 2018, 44(8), 1307-1316.
(9) Z Li, G Li, S Li, H Ding, TZhang, Y Song*,Magnetic field annealing of FeCo-based amorphous alloys to enhance thermal stability and Curie temperature. Rare Met, 2018, DOI 10.1007/s12598-018-1069-z.
(10)W Zhang, X Ding, J Li, N Tiercelin, P Pernod, Y Song*, Tunable Magneto-Optical Kerr Effects of Nanoporous Thin Films, Sci Rep, 2017, 7, 2888.
(11)J Wang, Y Song*, Microfluidic Synthesis of Nanohybrids. Small 2017, 13, 1604084.
(12)J Wang, Z Wang, S Li, R Wang, Y Song*, Surface and interface engineering of FePt/C nanocatalysts for electro-catalytic methanol oxidation: enhanced activity and durability. Nanoscale 2017, 9, 4066-4075
(13)Z Wang, H Fan, H Liang, J Ma, S Li, Y Song*, RWang, Microfluidic Synthesis and Characterization of FePtSn/C Catalysts with Enhanced Electro-Catalytic Performance for Direct Methanol Fuel Cells. Electrochimica Acta 2017, 230: 245–254
(14) H Liang, Z Wang, J Wang,D Huang, Y Zhu, Z Liu,Y Song*, Synthesis of Fe(1-x)Znx@Zn(1-y)FeyOz Nanocrystals via a Simple Programmed Microfluidic Process", Mater Chem & Phys2017, 201, 156-164.
(15)Y Song*, K T. Hart and K M. Dooley, Waste-Reducing Catalytic Oxidation of m-Xylene to m-Toluic Acid. Catal. Lett. 2016, 146: 1213–1220.
(16)JWang, Kai Zhao, Xiaomiao Shen, Weiwei Zhang, Shaoxia Ji, Yujun Song*, Xiaodong Zhang, Rong Rong and Xiaoying Wang, Microfluidic synthesis of ultra-small magnetic nanohybrids for enhanced magnetic resonance imaging, J. Mater. Chem. C, 2015, 3: 12418-12429.
(17)R Wang, Wantai Yang, Yuanjun Song, Xiaomiao Shen, Junmei Wang, Xiaodi Zhong, Shuai Li & Yujun Song*, A General Strategy for Nanohybrids Synthesis via Coupled Competitive Reactions Controlled in a Hybrid Process, Sci. Rep. 2015, 5: 9189
(18)Y Song*, W Yin, Y Wang, J Zhang, Y Wang, R Wang, JHan, W Wang, S V. Nair, H E. Ruda*, Magneto-plasmons in periodic nanoporous structures. Sci. Rep. 2014, 4: 4991.
(19)Y Song*, Y Wang, B Li, F Carlos and H Ruda, Interface interaction induced ultra-dense nanoparticle assembles. Nanoscale, 2013, 5: 6779-6789
(20)Z. Tang, Y. Song*, Y. Jiang and T. Zhang, Magnetic Field Driving Gradient Microstructural Amorphous-nanocrystalline Cobalt Alloy Ribbons. Nanoscale, 2012, 4: 386-391.
(21)容蓉; 丁杰; 王霄英*; 姜原; 蔡文超; 邱建星; 宋玉军*, 双能 C T 应用于分子影像学的可行性初探--模体实验. 放射学实践 2012, 27 (7), 713-717
(20)Y. Song*, R. Wang, R. Rong, et al., Synthesis of Well-Dispersed Aqueous-Phase Magnetite Nanoparticles and their Metabolism as an MRI Contrast Agent for the Reticuloendothelial System. Eur. J. Inorg. Chem. 2011: 3301-3313.
(21)Y Song, P D. Nallathamby, T Huang, H E. Elsayed-Ali, X-H N. Xu, Correlation and Characterization of 3D Morphological Dependent Localized Surface Plasmon Resonance Spectra of Single Silver Nanoparticles Using Dark-field Optical Microscopy and AFM. J. Phys. Chem. C 2010,114: 74-81
(22)Y Song*, L L Henry and W Yang, In-situ Rapid Cooling Formation of Amorphous Co Nanoparticles via a Microfluidic Reactor Process. Langmuir, 2009, 25(17): 10209-17.
(23)Y Song, Challa Kumar and Josef Hormes, Microfluidic Synthesis of Nanomaterials. Small, 2008, 4(6): 698-711.