研究领域
研究工作主要涉及天然活性物质，有机合成，生物大分子及其复合物的X射线晶体结构及其功能。生物大分子的晶体结构，为认识及理解生物大分子的结构、相关功能以及相关生命过程的反应机理提供了原子水平的基础。
海洋生物产品工程学
以“微藻生物加工厂”为基础，生产相关的能源物质，如氢气、油、淀粉为以及其重要合成途径中关键酶及酶群的晶体结构的研究。
基于海绵相关微生物以及微藻中的活性蛋白酶在化工合成中的应用
基于海绵相关微生物的活性物质的分离提取及结构鉴定，从而为开展以结构生物学为导向的新药发现提供先导化合物。
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Hai-Tao Wang, Chang-Hong Yao, Ya-Nan Liu, Ying-Ying Meng, Wei-Liang Wang, Xu-Peng Cao, Song Xue. Identification of fatty acid biomarkers for quantification of neutral lipids in marine microalgae Isochrysis zhangjiangensis. Journal of Applied Phycology. 2014, DOI 10.1007/s10811-014-0300-z
Yingying Meng, Changhong Yao, Song Xue, Haibo Yang. Application of Fourier transform infrared (FT-IR) spectroscopy in determination of microalgal compositions. Bioresource Technology, 2014, 151:347-354
Chang-Hong Yao, Jiang-Ning Ai, Xu-Peng Cao, Song Xue. Salinity manipulation as an effective method for enhanced starch production in the marine microalga Tetraselmis subcordiformis. Bioresource Technology ,2013,146: 663-671.
Chang-Hong Yao, Jiang-Ning Ai, Xu-Peng Cao, Song Xue. Characterization of cell growth and starch production in the marine green microalga Tetraselmis subcordiformis under extracellular phosphorus-deprived and sequentially phosphorus-replete conditions. Applied Microbiology and Biotechnology, 2013, 97:6099–6110.
Xinglong Dong, Zhaoan Chen, Song Xue, Jinling Zhang, Jiannan Zhou, Yanan Liu,Yunpeng Xu, Zhongmin Liu. Catalytic pyrolysis of microalga Chlorella pyrennoidosa for production of ethylene, propylene and butane. RSC Advances.2013,3, 25780-25787.
Changhong Yao，Jiangning Ai，Xupeng Cao，Song Xue，Wei Zhang. Enhancing starch production of a marine green microalga Tetraselmis subcordiformis through nutrient limitation. Bioresource Technology,2012,118,438-444.
Yanjuan Xin,Manmadhan Kanagasabhapathy, Dorte Janussen, Song Xue,Wei Zhang. Phylogenetic diversity of Gram-positive bacteria cultured from Antarctic deep-sea sponges. Journal of Basic Microbiology, 2011,34(10) :1501-1502.
Dina Feng, Zhaoan Chen, Xue Song, Wei Zhang. Increased Lipid Production of the Marine Oleaginous Microalgae Isochrysis zhangjiangensis (Chrysophyta) by Nitrogen Supplement. Bioresource Technology, 2011, 102 :6710-6716.
Chao-Fan Ji, Xing-Ju Yu, Zhao-An Chen, Song Xue, Jack Legrand, Wei Zhang. Effects of nutrient deprivation on biochemical compositions and photo-hydrogen production of Tetraselmis subcordiformis. International Journal of Hydrogen Energy, 2011,36: 5817-5821
Xue S, Wang R, Yang F, Terns RM, Terns MP, Zhang X, Maxwell ES, Li H. Structural basis for substrate placement by an archaeal box C/D ribonucleoprotein particle. Mol Cell,2010, 39:939-949.
Michelle Mitchell, Song Xue, Rachel Erdman, Lennart Randau, Dieter Soll and Hong Li. Crystal structure and assembly of the functional Nanoarchaeum equitans tRNA splicing endonuclease.Nucleic Acids Research , 2009,37(17): 5793-5802.
Kate Calvin, Song Xue, Charles Ellis, Michelle H. Mitchell, and Hong Li, Probing the Catalytic Triad of an Archaeal RNA Splicing Endonuclease. Biochemistry, 2008,47(51):13659-65 .
Bo Liang*, Song Xue*, Rebecca M Terns, Michael P Terns & Hong Li. Substrate RNA Positioning in the Archaeal H/ACA Ribonucleoprotein Complex. Nature Structural & Molecular Biolog ,2007,14: 1189 - 1195 . (*These authors contributed equally to this work)
Min Donghong., Song Xue, Hong Li, Yang Wei. In-line Conformation Plays a Modes t Role in an Enzyme-catalyzed RNA Cleavage: a Free Energy Simulation Study. Nucleic Acids Research, 2007,35(12): 4001-4006.
Song Xue, Kate Calvin, Hong Li. RNA Recognition and Cleavage by an RNA Splicing Endonuclease. Science, 2006,312(5775): 906-910.
Kate Calvin, Michelle D. Hall, Fangmin Xu, Song Xue and Hong Li.Structural Characterization of the Catalytic Subunit of a Novel RNA Splicing Endonuclease. Journal of Molecular Biology, 2005,353 (5): 952-960.
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