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个人简介

教育经历 2006年9月-2009年6月 中山大学 有机化学 博士(陈新滋院士、鄢明教授) 2001年9月-2004年7月 中科院广州化学所 有机化学 硕士(邹永研究员) 1997年9月-2001年7月 聊城大学 化学教育 本科 工作经历 2011年12月至今 中山大学药学院 副教授 2018年至2019年 美国Scripps研究所 访问学者 (Prof. Phil Baran) 2009年至2011年 日本京都大学 博士后 (Prof. Tamio Hayashi) 2004年至2006年 中科院广州化学所 助理研究员

研究领域

过渡金属催化或者非金属参与的交叉偶联反应的研究 不对称合成及其在手性药物中的应用研究 抗菌抗结核药物的设计合成研究等

近期论文

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Jing-xuan Zhou, Dong-yu Zhu, Jie Chen, Xue-jing Zhang*, Ming Yan*, Albert S.C. Chan Polysulfonate supported chiral diamine-nickel catalysts: Synthesis and applications Tetrahedron Letters 65 (2021) ASAP Jie Chen, Dong-yu Zhu, Xue-jing Zhang,* and Ming Yan* Highly Enantioselective Addition of N‑2,2,2-Trifluoroethylisatin Ketimines to Ethylene Sulfonyl Fluoride J. Org. Chem. 2021, 86, 3041−3048 Zhen-Yu Chen, Bi-Zhen Lin, Lei Chen, Yong Zou, Ming Yan,* and Xue-Jing Zhang* Perfluorobutyl Iodide-Mediated [1,2] and [2,3] Stevens Rearrangement for the Synthesis of Indolin-3-ones Adv. Synth. Catal. 2020, 362, 4368-4372. Wen-tao Wei, Zhen-yu Chen, Yong-lu Lin, Ri-xing Chen, Qi Wang, Qing-guang Wu, Si-jun Liu, * Ming Yan, and Xue-jing Zhang* Synthesis of Isoindolinones through Intramolecular Amidation of ortho-Vinyl Benzamides Adv. Synth. Catal. 2020, 362, 1972– 1976. Flood, D. T.;# Zhang, X. J.;# (共同一作)Fu, X.; Zhao, Z. X.; Asai, S.; Sanchez, B. B.; Sturgell, E. J.; Vantourout, J. C.; Richardson, P.; Flanagan, M. E.; Piotrowski, D. W.; Kölmel, D. K.; Wan, J. Q.; Chang, Y.; Wang Z.; Chen, J. S.; Baran P. S.;* Dawson, P. E.* RASS-Enabled S/P–C and S–N Bond Formation for DEL Synthesis. Angew. Chem. Int. Ed. 2020, 59, 7377–7383. Dillon T. Flood, # Shota Asai, # (共一) Xuejing Zhang, Jie Wang, Leonard Yoon, Zoë C. Adams, Blythe C. Dillingham, Brittany B. Sanchez, Julien C. Vantourout, Mark E. Flanagan, David W. Piotrowski, Paul Richardson, Samantha A. Green, Ryan A. Shenvi, Jason S. Chen, Phil S. Baran,* and Philip E. Dawson* Expanding Reactivity in DNA-Encoded Library Synthesis via Reversible Binding of DNA to an Inert Quaternary Ammonium Support J. Am. Chem. Soc. 2019, 141, 9998-1000 Jie Chen, Bao-qin Huang, Zeng-qing Wang, Xue-Jing Zhang, Ming Yan* Asymmetric Conjugate Addition of Ethylene Sulfonyl Fluorides to 3-Amido-2-oxindoles: Synthesis of Chiral Spirocyclic Oxindole Sultams Org. Lett. 2019, 21, 9742–9746 Zhen-Yu Chen, Hua-Ju Liang, Ri-Xing Chen, Lei Chen, Xiang-Zheng Tang, Ming Yan, * and Xue-Jing Zhang,* Cross-Dehygrogenative C-O Coupling of Oximes with Acetonitrile, Ketones and Esters Adv. Synth. Catal. 2019, 361, 3324-3330. Lei Chen, Jie Liang, Zhen-yu Chen, Jie Chen, Ming Yan, * and Xuejing Zhang,* A Convenient Synthesis of Sulfones via Light Promoted Coupling of Sodium Sulfinates and Aryl Halides Adv. Synth. Catal. 2019, 361, 956-960. Lang Tong#, Zhifeng Mao#, Xiangzheng Tang, Xuejing Zhang*, Ming Yan* Cycloaddition of hydrazones and 1, 2-diarylalkynes promoted by t-BuOK/DMF: A convenient synthesis of tetraarylpyrazoles Chin. Chem. Lett. 2019, 30, 395–397. Xiang-zheng Tang, Lang Tong, Hua-ju Liang, Jie Liang, Yong Zou, Xue-jing Zhang, * Ming Yan * and Albert S. C. Chan Facile synthesis of substituted diaryl sulfones via a [3 + 3] benzannulation strategy Org. Biomol. Chem., 2018,16, 3560 Chen, Zi-cong; Tong, Lang; Du, Zhi-bo; Mao, Zhi-feng; Zhang, Xue-jing; Zou, Yong; Yan, Ming Annulation of β-​naphthols and 4-​hydroxycoumarins with vinylsulfonium salts: synthesis of dihydrofuran derivatives Organic & Biomolecular Chemistry 2018, 16, 2634-2638. Zhen-yu Chen, Liang-yu Wu, Hai-sheng Fang, Ting Zhang, Zhi-feng Mao, Yong Zou, Xue-jing Zhang and Ming Yan Intramolecular Hydroamidation of ortho-Vinyl Benzamides Promoted by Potassium tert-Butoxide/N,N-Dimethylformamide Adv. Synth. Catal. 2017, 357, 3894–3899. Ting Zhang, Lu Qian, Zhen-yu Chen, Yong Zou, Xue-jing Zhang,* and Ming Yan* Intramolecular dehydrogenative coupling of biaryl tertiary amines promoted with t-BuOK/DMF: A convenient synthesis of 6-aryl-5,6-dihydrophenanthridines Arkivoc 2017, (IV), 174-183. Lin-miao Ye, Jie Chen, Peng Mao, Xue-jing Zhang, Ming Yan* Visible-light promoted synthesis of 3-arylthioindoles from indoles anddiaryl disulfides Tetrahedron Letters, 2017, 58, 2743–2746. Lin-miao Ye, Jie Chen, Peng Mao, Zhi-feng Mao, Xue-jing Zhang, Ming Yan* Visible-light-promoted synthesis of benzothiazoles from 2-aminothiophenols and aldehydes Tetrahedron Letters, 2017, 58, 874-876. Lin-Miao Ye, Lu Qian, Yan-Yan Chen, Xue-Jing Zhang and Ming Yan,A practical synthesis of benzothiophenes via visible-light-promoted cyclization of disulfides and alkynes, Org. Biomol. Chem. 2017, 15, 550–554. Yan-yan Chen, Zhen-yu Chen, Niu-niu Zhang, Jia-hua Chen, Xue-jing Zhang, Ming Yan*, Intramolecular Addition of Triarylmethanes to Alkynes Promoted by KOtBu/DMF: A Synthetic Approach to Indene Derivatives, Eur. J. Org. Chem. 2016, 3, 599-606. Jia-hua Chen, Zi-cong Chen, Hong Zhao, Yong Zou, Xue-jing Zhang* and Ming Yan* Intramolecular cyclization of diarylmethanols and α,β-unsaturated amides promoted by KOt-Bu/DMF: a metal-free approach towards 3,4-disubstituted quinolinones Org. Biomol. Chem., 2016, 14, 11148. Jia-hua Chen, Zi-cong Chen, Hong Zhao, Ting Zhang, Wei-juan Wang, Yong Zou, Xue-jing Zhang* and Ming Yan Intramolecular addition of diarylmethanols to imines promoted by KOt-Bu/DMF: a new synthetic approach to indole derivatives Org. Biomol. Chem., 2016, 14, 4071–4076.

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