研究领域

药物化学和有机化学

近期论文

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20. Gou, Q.; Den, B.; Zhang, H.; Qin, J. “Arylations of substituted enamides by aryl iodides: regio- and stereoselective synthesis of (z)-β-amido-β-arylacrylates.”Org. Lett. 2013,15, 4604-4607. 

19．Li, H.; Qin, J.; Dhondi, P.; Zhou, W.; Vicarel, M.; Bara, T.; Cole, D.; Josien, H.; Pissarnitski, D.; Zhu, Z.; Palani, A.; Aslanian, R.; Clader, J.; Czarniecki, M.; Greenlee, W.; Cohen-Williams, M.; Hyde, L.; Song, L.; Zhang, L.; Chu, I.; Huang, X. “The discovery of fused oxadiazepines as gamma secretase modulators for treatment of Alzheimer's disease.”Bioorg. Med. Chem. Lett.2013, 23, 466-471. 

18．Friestad, G.; Ji, A.; Baltrusaitis, J.; Korapala, C.; Qin, J.“Scope of stereoselective Mn-mediated radical addition to chiral hydrazones and application in a formal synthesis of quinine.”J. Org. Chem.2012, 77, 3159-3180. 

17．Huang, X.; Su, J.; Rao, A.; Tang, H.; Zhou, W.; Zhu, X.; Chen, X.; Liu, Z.; Huang, Y.; Degrado, S.; Xiao, D.; Qin, J.;Aslanian, R.; McKittrick, B.; Greenfeder, S.; Van Heek, M.; Chintala, M.; Palani, A.“SAR studies of C2 ethers of 2H-pyrano[2,3-d]pyrimidine-2,4,7(1H,3H)-triones as nicotinic acid receptor (NAR) agonists.”Bioorg.Med.Chem. Lett.2012,22, 854-858. 

16．Sun, Z.; Asberom, T.; Bara, T.; Bennett, C.; Burnett, D.; Chu, I.; Clader, J.; Cohen-Williams, M.; Cole, D.; Czarniecki, M.; Durkin, J.; Gallo, G.; Greenlee, W.; Josien, H.; Huang, X.; Hyde, L.; Jones, N.; Kazakevich, I.; Li, H.; Liu, X.; Lee, J.; MacCoss, M.; Mandal, M.; McCracken, T.; Nomeir, A.; Mazzola, R.; Palani, A.; Parker, E.;Pissarnitski, D.; Qin, J.; Song, L.; Terracina, G.; Vicarel, M.; Voigt, J.; Xu, R.; Zhang, L.; Zhang, Q.; Zhao, Z.; Zhu, X.; Zhu, Z.“Cyclic hydroxyamidines as amide isosteres: discovery of oxadiazolines and oxadiazines as potent and highly efficacious γ-secretase modulators in vivo.”J. Med. Chem. 2012, 55, 489-502.

15．Qin, J.;Dhondi, P.; Huang, X.; Aslanian, R.; Fossetta, J.; Fang, T.;Lundell, D.;Palani, A.“Discovery ofapotentdihydrooxadiazole series of non-ATP-competitive MK2 (MAPKAPK2) inhibitors.”ACS Med. Chem.Lett. 2012, 3, 100-105. 

14．Palani, A.;Rao, A.; Chen, X.; Huang, X.; Su, J.; Tang, H.; Huang, Y.;Qin, J.; Xiao, D.; Degrado, S.;Sofolarides, M.; Zhu, X.; Liu, Z.; McKittrick, B.; Zhou, W.;Aslanian, R.; Greenlee, W.; Senior, M.;Cheewatrakoolpong, B.; Zhang, H.; Farley, C.; Cook, J.;Kurowski, S.; Li, Q.;VanHeek, M.; Wang, G.; Hsieh, Y.; Li, F.;Greenfeder, S.; Chintala, M. “Discovery of SCH 900271, a potent nicotinic acid receptor agonist for the treatment of dyslipidemia.”ACS Med. Chem. Lett.2012,3,63-68. 

13．Qin, J.;Zhou, W.; Huang, X.; Dhondi, P.; Palani, A.; Aslanian, R.; Zhu, Z.; Greenlee, W.; Cohen-Williams, M.; Jones, N.; Hyde, L.; Zhang, L. “Discovery of a potent pyrazolopyridine series of γ-secretase modulators.”ACSMed. Chem.Lett.2011, 2, 471-476. 

12．Qin, J.;Dhondi, P.; Huang, X.;Mandal, M.; Zhao, Z.;Pissarnitski, D.; Zhou, W.;Aslanian, R.; Zhu, Z.; Greenlee, W.;Clader, J.; Zhang, L.; Cohen-Williams, M.; Jones, N.; Hyde, L.;Palani, A.“Discovery of fused 5,6-bicyclic heterocycles as γ-secretase modulators.”Bioorg. Med. Chem. Lett.2011,21, 664-669. 

11．Qin, J.;Rao, A.; Chen, X.; Zhu, X.; Liu, Z.; Huang, X.;Degrado, S.; Huang, Y.; Xiao, D.; Aslanian, R.; Cheewatrakoolpong, B.; Zhang, H.; Greenfeder, S.; Farley, C.; Cook, J.; Kurowski, S.; Li, Q.;Van Heek, M.; Chintala, M.; Wang, G.; Hsieh, Y.; Li, F.; Palani, A. “Discovery of a potent nicotinic acid receptor agonist for the treatment of dyslipidemia.” ACS Med. Chem. Lett. 2011,2, 171-176
10．Friestad, G. K.; Ji, A.; Korapala, C. S.; Qin, J.“Intermolecular radical addition to N-acylhydrazones as a stereocontrol strategy for alkaloid synthesis: formal synthesis of quinine.”Org.  
Biomol.Chem.2011,9,4039-4043.
9．Huang, X.; Aslanian, R.; Zhou, W.; Zhu, X.; Qin, J.; Greenlee, W.; Zhu, Z.; Zhang, L.; Hyde, L.; Chu, I.; Cohen-Williams, M.; Palani, A. “The discovery of pyridone and pyridazoneheterocycles as γ-secretase modulators.”ACS Med.Chem.Lett.2010, 1, 184-187. 

8．Evans, P.A.; Qin, J.;Robinson, J.E.; Bazin, B.“Enantioselective total synthesis of the polycyclic guanidine containing marine alkaloid, (-)-Batzelladine D.”Angew.Chem.Int.Ed.2007,46, 7417-7419. 

7．Korapala, C.S.; Qin, J.;Friestad, G. K.“Quinine synthesis studies: a radical-ionic annulation via Mn-mediated addition to chiral N-acylhydrazones.”Org.Lett.2007,9,4243-4246. 

6．Friestad, G.K.; Marie, J.-C.; Suh, Y.; Qin, J. “Mn-mediated coupling of alkyl iodides and N-acylhydrazones: optimization, scope and evidence of radical mechanism.” J. Org. Chem.2006,71, 7016-7027. 

5．Friestad, G.K.; Draghici, C.; Soukri, M.; Qin, J.“Radical addition approach to asymmetric amine synthesis: design, implementation, and comparison of new chiral N-acylhydrazones.”J. Org. Chem.2005,70, 6330-6338. 

4．Qin, J.;Friestad, G.K.“Stereocontrol in hydride addition to ketone-derived chiral N-acylhydrazones.”Tetrahedron,2003,59, 6393-6402. 

3．Friestad,G.K.; Qin,J. “Intermolecular alkyl radical addition to chiral N-acylhydrazones mediated by manganese carbonyl.”J.Am.Chem.Soc.2001,123,9922-9923. 

2．Friestad, G.K.; Qin, J. “Highly stereoselective intermolecular radical addition to aldehyde hydrazones from chiral 3-amino-2-oxazolidinone.”J.Am. Chem. Soc. 2000, 122, 8329-8330. 

1．Li, X.-S.; Qin, J.; Zhang, X.-L.; Xie, R.-G. “A convenient synthesis of chiral sulfur-containingmacrocyclic ligands.”Synth.Commun.1997,27,3079-3085.