研究领域

1. 药物合成

2. 有机合成

近期论文

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1. Zhao, Li-Ming;* Zhang, Ai-Li; Zhang, Jie-Huan; Gao, Hua-Shuai; Zhou, Wei. Zinc-mediated C-3 α-prenylation of isatins with prenyl bromide: Access to 3-prenyl-3-hydroxy-2-oxindoles and its application. J. Org. Chem. 2016, 81 (13), 5487-5494.

2. Zhao, Li-Ming;* Cao, Feng-Xia; Zhang, Jie-Huan; Szwayab, Jeffrey; Wang, Guangdi.* One-pot synthesis of 1,4-dihydroxy-2-((E)-1-hydroxy-4-phenylbut-3-enyl)anthracene-9,10-diones as novel shikonin analogs and evaluation of their antiproliferative activities. Bioorg. Med. Chem. Lett. 2016, 26 (11), 2691-2694.

3. Zhao, Li-Ming;* Zhang, Ai-Li; Gao, Hua-Shuai; Zhang, Jie-Huan. Synthesis of furo[3,2-c]benzopyrans via an intramolecular [4 + 2] cycloaddition reaction of o-quinonemethides. J. Org. Chem. 2015, 80 (20), 10353-10358.

4. Zhao, Li-Ming;* Ma, Feng-Yan; Jin, Hai-Shan; Zheng, Shilong; Zhong, Qiu; Wang, Guangdi.* Design and synthesis of novel hydroxyanthraquinone nitrogen mustard derivatives as potential anticancer agents via a bioisostere approach. Eur. J. Med. Chem. 2015, 102, 303-309. 

5. Zhao, Li-Ming;* Zhang, Shu-Qing; Dou, Fei; Sun, Rui. Zinc-mediated highly α-regioselective 1,4-addition of chalcones with prenyl bromide in THF. Org. Lett. 2013, 15 (20), 5154-5157.

6. Zhao, Li-Ming;* Zhang, Shu-Qing; Jin, Hai-Shan; Wan, Li-Jing; Dou, Fei. Zinc-mediated highly α-regioselective prenylation of imines with prenyl bromide. Org. Lett. 2012, 14 (3), 886-889.

7. Zhao, Li-Ming;* Zhang, Li-Ming; Liu, Jin-Juan; Wan, Li-Jing; Chen, Yong-Qiang; Zhang, Shu-Qing; Yan, Zhi-Wei; Jiang Ji-Hong. Synthesis and antitumor activity of conjugates of 5-Fluorouracil and emodin. Eur. J. Med. Chem. 2012, 47, 255-260.

8. Zhao, Li-Ming;* Jin, Hai-Shan; Wan, Li-Jing; Zhang, Li-Ming. General and highly α-regioselective zinc-mediated prenylation of aldehydes and ketones. J. Org. Chem. 2011, 76 (6), 1831-1837.