贾潇凌 - 北京航空航天大学 - 生物与医学工程学院

个人简介

教育与工作经历 1988.9 - 1992.7 山西大学生物系生物专业、学士 1992.9 - 1995.7 山西大学生物系动物专业、硕士 1995.9 - 2003.3 中国辐射防护研究院助理研究员 2003.4 - 2007.7 中国科学院力学研究所生物力学、博士 2007.9 至今北京航空航天大学生物与医学工程学院讲师、副教授 2002.12 - 2003.3 香港中文大学生物医学学院访问学者 2019.7 - 2020.7 英国利兹大学生物医学学院访问学者主要社会兼职中国生物医学工程学会会员中国神经科学学会会员 Frontiers in Pharmacology （Ion channels） Associate editor (副主编) 主要教学获奖北航第十五届“我爱我师”十佳教师

研究领域

血管组织工程离子通道在物理因素调控细胞生理病理功能中的作用机制

近期论文

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Xiaoling Jia, Xinlan Chen, Chao Gao, et al. Functional cooperation between IKCa and TRPC1 channels regulates serum-induced vascular smooth muscle cell proliferation via mediating Ca2+ influx and ERK1/2 activation. Cell Prolif 2022 23;e13385. Philippa Malko, Xiaoling Jia, Ian Wood, Lin-Hua Jiang. Piezo1 channel-mediated Ca2+ signaling inhibits lipopolysaccharide-induced activation of the NF-κB inflammatory signaling pathway and generation of TNF-αand IL-6 in microglial cells. Glila. 2022. doi: 10.1002/glia.24311. Xiaoling Jia, Qingmao Yang, Chao Gao, et al. Stimulation of vascular smooth muscle cell proliferation by stiff matrix via the IKCa channel‐dependent Ca2+ signaling. J Cell Physiol . 2021;236(10):6897-6906. Xiaoling Jia, Chao Gao, Xia Wang, et al. Differential regulation by mechanical stretch of the expressions of large?conductance Ca2+?activated K+ channel and L?type voltage?dependent Ca2+ channel in rat uterine smooth muscle cells. J Membr Biol. 2022;255(2-3):357-361. Xiaoling Jia, Hao Su, Xinlan Chen, et al. A critical role of the KCa3.1 channel in mechanical stretch-induced proliferation of rat bone marrow-derived mesenchymal stem cells. J Cell Mol Med. 2020 ;24(6):3739-3744. Yang Yang, Qingmao Yang, Fang Zhou, Yunhui Zhao, Xiaoling Jia*, Xiaoyan Yuan, Yubo Fan. Electrospun PELCL membranes loaded with QK peptide for enhancement of vascular endothelial cell growth. J Mater Sci Mater Med. 2016 ;27(6):106. co-correspondence Fang Zhou, Xiaoling Jia#, Qingmao Yang, et al. Targeted delivery of microRNA-126 to vascular endothelial cells via REDV peptide modifified PEG-trimethyl chitosan. Biomater Sci 2016 May 26;4(5):849-56. co-first Fang Zhou, Xiaoling Jia#, Yang Yang, et al. Nanofiber-mediated microRNA-126 delivery to vascular endothelial cells for blood vessel regeneration. Acta Biomater. 2016 ;43:303-313. co-first Zhou Fang, Xiaoling Jia#, Yang Y, et al. Peptide-modifified PELCL electrospun membranes for regulation of vascular endothelial cells. Mater Sci Eng C Mater Biol Appl. 2016 ;68:623-631. co-first Jie Fan, Xiaoling Jia, Yan Huang, et al. Greater scaffold permeability promotes growth of osteoblastic cells in a perfused bioreactor. J Tissue Eng Regen Med. 2015;9(12):E210-8. Xufeng Niu, Pin Chen, Xiaoling Jia, et al. Microencapsulation of mechano growth factor E peptide for sustained delivery and bioactivity maintenance. Int J Pharm. 2014;469(1):214-21. Hong Zhang, Xiaoling Jia#, Fengxuan Han, et al. Dual-Delivery of VEGF and PDGF by Double-layered Electrospun Membranes for Blood Vessel Regeneration. Biomaterials. 2013;34(9): 2202-2212. co-first Fengxuan Han, Xiaoling Jia#, D Dai, et al. Performance of a multilayered small-diameter vascular scaffold dual-loaded with VEGF and PDGF. Biomaterials. 2013;34(30): 7302-7312. co-first Xiaoling Jia, Jingyun Yang, Wei Song, et al. Involvement of large conductance Ca2+-activated K+ channel in laminar shear stress-induced inhibition of vascular smooth muscle cell proliferation. pflugers archiv-european journal of physiology 2013;465:221-232. Meiliang Li, Xiaoling Jia#, Jingyun Yang , et al. Effect of tannic acid on properties of soybean seed ferritin: A model for interaction between naturally -occurring components in foodstuffs. Food Chemistry 2012;133:410-415 co-first Xiaoling Jia, Chenguang Zhao, Ping Li, et al. Sustained release of VEGF by coaxial electrospun dextran/PLGA fibrous membranes in vascular tissue engineering. Journal of biomaterial science-polymer edition. 2011;22:1811-1827. Chenyan Lv, Xiaoling Jia#, Meiliang Li, et al. Optimization of extraction process of crude protein from grape seeds by RSM. Food Sci and Technol Res 2011;17:437-445. Co-first co-first Yan Huang, Xiaoling Jia, Ke Bai, et al. Effects of fluid shear stress on cardiomyogenic differentiation of rat bone marrow mesenchymal stem cells. Arch Med Res 2010 ;41(7):497-505. Ping Li, Feng X, xiaoling Jia, Yubo Fan. nfluences of tensile load on in vitro degradation of an electrospun poly(L-lactide-co-glycolide) scaffold. Acta Biomater. 2010;6(8):2991-2996. Xin Gu, Xiaoling Jia#, Jiannan Feng, et al. Molecular modeling and affinity determination of scFv antibody: proper linker peptide enhances its activity. Ann Biomed Eng. 2010, 38:537-549. co-first Xiaoling Jia, Juan Chen and Mian Long. IL-8-induced L-selectin shedding regulates its binding kinetics to PSGL-1. Chinese Science Bulletin. 2009,54:2787-2793. Mian Long, Xiaoling Jia. Selectin shedding regulates two-dimensional binding to PSGL-1. Biorheology 2008, 45:74-75. Li Wu, Botao Xiao, Xiaoling Jia, et al. Impact of carrier stiffness and microtopology on two-dimensional kinetics of P-selectin and P-selectin glycoprotein ligand-1 interactions. Journal of biological chemistry 2007, 282:9846-9854