郑丽沙 - 北京航空航天大学 - 生物与医学工程学院

个人简介

教育与工作经历 1998-2003 北京大学临床医学检验/本科 2003-2008 中科院生物物理所生物化学与分子生物学/博士 2008-2012 北航生物与医学工程学院讲师 2012 香港理工大学医疗科技及资讯学系助理研究员 2018-2019 美国哥伦比亚大学访问学者 2012-2021 北航生物与医学工程学院副教授 2021-今北航生物与医学工程学院教授主要学术获奖入选北京高等学校“青年英才计划”（2013）北京航空航天大学“蓝天新星”称号（2012）北京航空航天大学“蓝天新秀”称号（2009）主要教学获奖北京市高等教育教学成果奖二等奖（2018） “挑战杯”首都大学生课外学术科技作品竞赛优秀指导老师 (2017) 全球工程医疗创新竞赛铜奖指导教师 (2017) 北航教学优秀奖二等奖 (2017) 第十六届“我爱我师”优秀教师 (2017) 校级优秀班主任 (2015) 北京航空航天大学教学成果奖二等奖 (2014)

研究领域

骨与口腔力学生物学生物材料调控干细胞分化机理研究物理因子调控组织再生及机制研究

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

J Na, LY Zhang, LS Zheng*, JY Jiang, QS Shi, CY Li, YB Fan*. Static magnetic feld regulates proliferation, migration, and diferentiation of human dental pulp stem cells by MAPK pathway[J]. Cytotechnology.2022,Accepted. J Na, LS Zheng*, LJ Wang, QS Shi, ZJ Yang, N Liu, YW Guo, YB Fan*. Phenytoin Regulates Migration and Osteogenic Differentiation by MAPK Pathway in Human Periodontal Ligament Cells [J]. Cell Mol Bioeng. 2022;15(1):151-160. LS Zheng, QS Shi, J Na, N Liu, YW Guo, YB Fan. Platelet-Derived Growth Factor Receptor-alpha and beta are Involved in Fluid Shear Stress Regulated Cell Migration in Human Periodontal Ligament Cells [J]. Cell Mol Bioeng. 2019;12(1):85-97. Y Huang, HK Deng, YB Fan, LS Zheng, JF Che, XM Li, KE Aifantis. Conductive nanostructured Si biomaterials enhance osteogeneration through electrical stimulation [J]. Materials Science & Engineering C-Materials for Biological Applications. 2019;103. LS Zheng, LS Zhang, LP Chen, JY Jiang, XC Zhou, M Wang, YB Fan. Static magnetic field regulates proliferation, migration, differentiation, and YAP/TAZ activation of human dental pulp stem cells [J]. J Tissue Eng Regen Med. 2018;12(10):2029-2040. (封面论文) LS Zheng, JY Jiang, JP Gui, LY Zhang, XY Liu, Y Sun, YB Fan. Influence of Micropatterning on Human Periodontal Ligament Cells' Behavior [J]. Biophys J. 2018;114(8):1988-2000. SA Xie, T Zhang, J Wang, F Zhao, YP Zhang, WJ Yao, SS Hur, YT Yeh, W Pang, LS Zheng, YB Fan, W Kong, X Wang, JJ Chiu, J Zhou. Matrix stiffness determines the phenotype of vascular smooth muscle cell in vitro and in vivo: Role of DNA methyltransferase 1 [J]. Biomaterials. 2018;155:203-216. LS Zheng, LP Chen, JP Gui, Q Li, Y Huang, ML Liu, XL Jia, W Song, J Ji, XH Gong, RS Shi, YB Fan. The effects of fluid shear stress on proliferation and osteogenesis of human periodontal ligament cells [J]. J Biomech. 2016;49(4):572-579. (亮点关注) LP Chen, LS Zheng*, JY Jiang, JP Gui, LS Zhang, Y Huang, XF Chen, J Ji, YB Fan*. Calcium Hydroxide-induced Proliferation, Migration, Osteogenic Differentiation, and Mineralization via the Mitogen-activated Protein Kinase Pathway in Human Dental Pulp Stem Cells [J]. J Endod. 2016;42(9):1355-1361. LS Zheng, YT Liu, L Chen, Y Wang, YN Rui, HZ Huang, SY Lin, J Wang, ZX Wang, SC Lin, JW Wu. Structure and mechanism of the unique C2 domain of Aida [J]. FEBS J. 2014;281(20):4622-4632. XM Li, Y Huang, LS Zheng, HF Liu, XF Niu, J Huang, F Zhao, YB Fan. Effect of substrate stiffness on the functions of rat bone marrow and adipose tissue derived mesenchymal stem cells in vitro [J]. J Biomed Mater Res A. 2014;102(4):1092-1101. XH Gong, HF Liu, XL Ding, ML Liu, X Li, LS Zheng, XL Jia, G Zhou, YW Zou, JC Li, XJ Huang, YB Fan. Physiological pulsatile flow culture conditions to generate functional endothelium on a sulfated silk fibroin nanofibrous scaffold [J]. Biomaterials. 2014;35(17):4782-4791. ML Liu, W Song, P Li, Y Huang, XH Gong, G Zhou, XL Jia, LS Zheng, YB Fan. Galanin protects against nerve injury after shear stress in primary cultured rat cortical neurons [J]. PLoS One. 2013;8(5):e63473. XL Jia, JY Yang, W Song, P Li, X Wang, CD Guan, L Yang, Y Huang, XH Gong, ML Liu, LS Zheng, YB Fan. Involvement of large conductance Ca(2+)-activated K (+) channel in laminar shear stress-induced inhibition of vascular smooth muscle cell proliferation [J]. Pflugers Arch. 2013;465(2):221-232. LS Zheng, YY Zhang, JW Wu, ZWu, ZY Zhang, ZX Wang. A continuous spectrophotometric assay for mitogen-activated protein kinase kinases [J]. Anal Biochem. 2012;421(1):191-197. LS Zheng, Y Huang, W Song, XH Gong, ML Liu, XL Jia, G Zhou, LP Chen, A Li, YB Fan. Fluid shear stress regulates metalloproteinase-1 and 2 in human periodontal ligament cells: involvement of extracellular signal-regulated kinase (ERK) and P38 signaling pathways [J]. J Biomech. 2012;45(14):2368-2375. Y Huang, LS Zheng, XH Gong, XL Jia, W Song, ML Liu, YB Fan. Effect of cyclic strain on cardiomyogenic differentiation of rat bone marrow derived mesenchymal stem cells [J]. PLoS One. 2012;7(4):e34960. L Chen, ZH Jiao, LS Zheng(共同第一作者), YY Zhang, ST Xie, ZX Wang, JW Wu. Structural insight into the autoinhibition mechanism of AMP-activated protein kinase [J]. Nature. 2009;459(7250):1146-1149. 石秋生,纳静,杨智杰,李心杨,陈鑫远,武弋,樊瑜波,郑丽沙.剪切力通过p38-YAP/TAZ通路调节人牙周膜细胞增殖[J].医用生物力学,2021,36(S1):203. 李驰宇,郭雨薇,纳静,杨智杰,宋亚欣,樊瑜波,郑丽沙.细胞形状调控人牙髓干细胞干性维持及其机制研究[J].医用生物力学,2021,36(S1):90. 陈罗萍,郑丽沙,樊瑜波.Wnt信号通路对氢氧化钙促进人牙髓干细胞成骨向分化的调控[J].国际生物医学工程杂志,2019(02):120-124. 张灵玉,江静怡,樊瑜波,郑丽沙.磁场在骨生物学领域:研究与应用中明确和未明确问题[J].中国组织工程研究,2019,23(04):584-590. 张泽茜,伍佳琪,樊瑜波,郑丽沙.干细胞心肌向分化成熟过程中的物理刺激方法[J].中国组织工程研究,2019,23(01):110-117. 江静怡,樊瑜波,郑丽沙.力学因素对间充质干细胞神经向分化的影响[J].中国组织工程研究,2018,22(17):2761-2768. 桂金鹏,江静怡,张灵玉,纳静,樊瑜波,郑丽沙.力学因素对细胞自噬的影响[J].中国组织工程研究,2017,21(12):1946-1952. 黄天辉,桂金鹏,郑丽沙.利用酶制剂改善再造烟叶品质研究进展[J].东北农业大学学报,2015,46(10):102-108. 陈罗萍,张桂荣,郑丽沙,黄燕,樊瑜波.流体剪切力对成骨细胞LEF-1蛋白表达的影响[J].现代生物医学进展,2013,13(22):4230-4232 周钢,孙艳,李萍,郑丽沙,宋崴,牛旭锋,刘文勇,刘美丽,樊瑜波,杨欣.生物医学工程专业微生物实验课程体系改革与实践[J].实验室研究与探索,2012,31(10):95-97. 郑丽沙,李德玉,荣龙,周钢,樊瑜波.面向非生物专业本科生的“生命科学导论”教学改革初步探索[J].重庆工商大学学报(自然科学版),2012,29(07):112-114. 陈雷,焦智浩,郑丽沙,张媛媛,解树涛,王志新,吴嘉炜.糖尿病关键蛋白AMPK的自抑制机制[J].生物物理学报,2009,25(S1):97. 郑丽沙,陈雷,王盈,王大成,王志新,林圣彩,吴嘉炜. Axin相关蛋白Aida的结构及功能研究[C].第九届全国酶学学术讨论会暨邹承鲁诞辰85周年纪念会论文摘要集,2008:96.

学术兼职

中国力学学会生物力学专业委员会，委员、秘书中国生物医学工程学会医学检验工程分会，两届委员中国生物医学工程学会会员中国生物材料学会会员中国细胞生物学学会会员