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个人简介

教育经历 1991-1996 天津医科大学医疗系,临床医学 医学学士学位 1996-2001 中国协和医科大学,皮肤与性病学 医学博士学位 工作经历 2001-2004 北京航空航天大学,生物工程系 讲师 2004-2008 北京航空航天大学,生物工程系 副教授、副主任 2005-2006 德国柏林自由大学&洪堡大学Charité医学院 访问学者 2008-2010 北京航空航天大学,生物与医学工程学院 副教授、副院长 2010 Charité医科大学,柏林空天医学中心 访问学者 2010-2012 北京航空航天大学,生物与医学工程学院 教授、副院长 2015 德州大学圣安东尼奥分校 访问学者 2016 Charité医科大学,柏林空天医学中心 高级访问学者 2017 英国伦敦大学学院 高级访问学者 2012-现在 北京航空航天大学,生物与医学工程学院 教授、博导 主要社会兼职 中国空间科学学会空间生命专业委员会副主任委员 中国空间科学学会常务理事 全国空间科学及应用标准化技术委员会(生命交叉科学)标准化工作组成员

研究领域

航空航天生物医学工程 空间生命科学 生物力学与力生物学

近期论文

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Li-Jin Liu, Yu-Bo Fan, Shou-Hui Wang, Xin-Tong Wu, Xiao Yang*, Lian-Wen Sun*. Enhanced osteogenic potential of periosteal stem cells maintained cortical bone relatively stable under microgravity. Acta Astronautica, 2023, 205: 163-171. Fei-Xiang Lu, Shou-Hui Wang, Xing-Tong Wu, Xiao Yang, Lian-Wen Sun*, Yu-Yo Fan*, Role of myofascia in the recovery of bone loss after reloading in tail-suspended rats, Acta Astronautica, 2023, 208: 49-54. Cong-Jin Liu, Xiao Yang*, Yan Mao, Xiao-Xue Zhang, Xin-Tong Wu, Shou-Hui Wang, Yu-Bo Fan, Lian-Wen Sun*. The alteration of advanced glycation end products and its potential role on bone loss under microgravity, Acta Astronautica, 2023, 206: 114-122. Cong-Jin Liu, Xiao Yang*, Shou-Hui Wang, Xin-Tong Wu, Yan Mao, Jing-Wen Shi, Yu-Bo Fan, Lian-Wen Sun*. Preventing Disused Bone Loss Through Inhibition of Advanced Glycation End Products, International Journal of Molecular Sciences, 2023, 24(5): 4953. Li-Jin Liu, Yu-Bo Fan, Xin-Tong Wu, Xiao Yang*, Lian-Wen Sun*. Comparison of stem cell characteristics between perichondral-derived stem cells and periosteal stem cells in postnatal rats. Medicine in Novel Technology and Devices, 2023, 18: 100238. Zhuang Han, Lian-Wen Sun, Xiao Yang, Xin-Tong Wu*, Yu-Bo Fan*. A hierarchical 3d finite element model of osteocyte: the spectrin membrane skeleton in mechanical transmission. Journal of Computational Science, 2023, 67: 101947. Yu-Hao Tong, Xiao Yang, Xin-Tong Wu, Shou-Hui Wang, Li-Jin Liu, Lian-Wen Sun*, Yu-Bo Fan*. The effect of periodic stretching on countering bone loss in hindlimb unloading rat, Acta Astronautica, 2022,190: 202-207. Li-Jin Liu, Shuang Li, Xin-Tong Wu, Xiao Yang*, Lian-Wen Sun*. Contribution of endoplasmic reticulum stress response to the mechanosensitivity alteration in osteocytes under simulated microgravity, Acta Astronautica, 2022, 191: 522-527. Xin-Tong Wu, Xiao Yang, Ran Tian, Ying-Hui Li, Chun-Yan Wang, Yu-Bo Fan*, Lian-Wen Sun*. Review: Cells Respond to Space Microgravity through Cytoskeleton Reorganization. The FASEB J. 2022, 36(2): e22114. Shou-Hui Wang, Xiao Yang, Zhuang Han, Xin-Tong Wu, Yu-Bo Fan*, Lian-Wen Sun*. Changes of cortical bone pores structure and their effects on mechanical properties in tail-suspended rats. Medicine in Novel Technology and Devices, 2022, 16: 100175. Zhuang Han, Lian-Wen Sun, Xin-Tong Wu, Xiao Yang*, Yu-Bo Fan*. Nonlinear dynamics of membrane skeleton in osteocyte. Computer Methods in Biomechanics and Biomedical Engineering, 2022, 26(3): 1-12. RunYu Cao, Wen Xiao, Feng Pan, Ran Tian, Xin-Tong Wu*, Lian-Wen Sun*. Displacement and strain mapping for osteocytes under fluid shear stress using digital holographic microscopy and digital image correlation. Biomedical Optics Express. 2021, 12(4): 1922-33. Shou-Hui Wang, Xiao Yang, Dong Ding, Xin-Tong Wu, Zhuang Han, Lian-Wen Sun*, Yu-Bo Fan*.The changes of bone vessels and their role in bone loss in tail-suspended rats. Acta Astronautica, 2021, 189: 368–378. Xiao Yang, Cong-Jin Liu, Zhen-Zhen Wang, Dong Ding, Jing-Wen Shi, Xin-Tong Wu, Lian-Wen Sun*, Yu-bo Fan*. Effects of advanced glycation end products on osteocytes mechanosensitivity, Biochemical and Biophysical Research Communications, 2021, 568: 151-157. Dong Ding, Xiao Yang, Hui-Qin Luan, Xin-Tong Wu, Lian-Wen Sun*, Yu-Bo Fan*. The microgravity induces the ciliary shortening and an increased ratio of anterograde/retrograde intraflagellar transport of osteocytes. Biochemical and Biophysical Research Communications, 2020, 530: 167-172. Dong Ding, Xiao Yang, Hui-Qin Luan, Xin-Tong Wu, Cai He, Lian-Wen Sun*, Yu-Bo Fan*. Pharmacological Regulation of Primary Cilium Formation Affects the Mechanosensitivity of Osteocytes. Calcified Tissue International, 2020: 1-11. Dietter Blottner*, Yun-Fei Huang, Gabor Trautmann, Lian-Wen Sun*. The fascia: Continuum linking bone and myofascial bag for global and local body movement control on Earth and in Space. A scoping review. REACH - Reviews in Human Space Exploration, 2019, 14-15: 100030. Wen Xiao, Qixiang Wang, Feng Pan, Runyu Cao, Xin-Tong Wu, Lian-Wen Sun*. Adaptive frequency filtering based on convolutional neural networks in off-axis digital holographic microscopy. Biomedical Optical Express. 2019, 10(4): 1613-1626. Xin-Tong Wu, Wen Xiao, Runyu Cao, Xiao Yang, Feng Pan, Lian-Wen Sun*, Yu-Bo Fan*. Spontaneous cellular vibratory motions of osteocytes are regulated by ATP and spectrin network. Bone, 2019, 128: 112056. Shou-Hui Wang, Wenting Li, Xiao Yang, Yun-Fei Huang, Lian-Wen Sun*, Yu-Bo Fan. Musculoskeletal alterations of hindlimb during simulated microgravity and reloading in rats: compared by gender. Microgravity Science and Technology. 2019, 31(4): 347-355. Dong Ding, Xiao Yang, Hui-Qin Luan, Xin-Tong Wu, Lian-Wen Sun*, Yu-Bo Fan*. The microgravity induces the ciliary shortening and an increased ratio of anterograde/retrograde intraflagellar transport of osteocytes. Biochemical and Biophysical Research Communications, 2020, 530: 167-172. Shou-Hui Wang, Xiao Yang, Min Wang, Yun-Fei Huang, Dieter Blottner, Lian-Wen Sun*, Yu-Bo Fan*. The role of body fluid shifts on hindlimb bone loss in tail suspended rats using a novel body fluid alteration device. Acta Astronautica. 2019, 159:1-7. Yun-Fei Huang, Hui-Qin Luan, Lian-Wen Sun*, Shou-Hui Wang, Yu-Bo Fan*. Increased Blood Flow by Unilateral Intermittent Compression on Hindlimbs May Prevent Bone Loss. Microgravity Science and Technology, 2018, 30: 987-993. Lian-Wen Sun, Shuang Li, Xiao Yang, Fang Pu, Hongyu Qi*, Yu-Bo Fan*. Contribution of bone micromechanical behavior beyond lamellar length scale to the macroscopic bone quality of hind limb unloading rats. Acta Astronautica. 2018, 152: 468–473. Yun-Fei Huang, Yu-Bo Fan, Michele Salanova, Xiao Yang, Lian-Wen Sun*, Dieter Blottner. Effects of Plantar Vibration on Bone and Deep Fascia in a Rat Hindlimb Unloading Model of Disuse. Frontiers in Physiology, 2018, 9: 616. Xiao Yang, Lian-Wen Sun*, Chengfei Du, Xin-Tong Wu, Yu-Bo Fan*. Finite element analysis of osteocytes mechanosensitivity under simulated microgravity, Microgravity Science and Technology, 2018, 30: 469-481. Runyu Cao, Wen Xiao, Xin-Tong Wu, Lian-Wen Sun*, Feng Pan*. Quantitative observations on cytoskeleton changes of osteocytes at different cell parts using digital holographic microscopy. Biomedical Optics Express 2018, 9(1): 72-85. 专著(Book) Xiao Yang, Lian-Wen Sun, Xiaodu Wang*. A Closer Look at Glycation: A Potential Hotspot for Age-Related Complications and Diseases (Chapter 5: Effects of Advanced Glycation End Products (Ages) on Bone Biomechanics and Remodeling). Nova Science Publishers. 2021.3.4. ISBN: 978-1-53619-176-9. 孙联文,杨肖,吴欣童。细胞力学及力学生物学(译著,原著 Introduction to cell mechanics and mechanobiology.),科学出版社。2023. 2. ISBN: 978-7-03-074583-5.

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