Ahn, Natalie - University of Colorado - Chemistry and Biochemistry

个人简介

Ph.D.: University of California, Berkeley, 1985 Postdoctoral Fellow: University of Washington, Seattle

研究领域

Cell Signaling Informatics & Proteomics Molecular Biophysics

近期论文

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Couts, K.L., Anderson, E.M., Gross, M.M., Sullivan, K. and Ahn, N.G. (2012) Oncogenic B-Raf signaling in melanoma cells controls a network of microRNAs with combinatorial functions. Oncogene, In press. Wang, D., Zhang, Z., O’Loughlin, E., Lee, T., Houel, S., O’Carroll, D., Tarakhovsky, A., Ahn, N.G. and Yi, R. (2012) Quantitative functions of Argonaute proteins in mammalian development. Genes Dev., In press. Luo, Y., Ellis, L.Z., Dallaglio, K., Takeda, M., Robinson, W.A., Robinson, S., Lewis, K.D., McCarter, M.D., Gonzalez, R., Norris, D.A., Roop, D.R., Ahn, N.G. and Fujita, M. (2012) Side population cells from human melanoma tumors reveal diverse mechanisms of chemoresistance. J. Invest. Dermatol., In press. Yen, C.Y., Houel, S., Ahn, N.G., and Old, W.M. (2011) Spectrum-to-spectrum searching using a proteome-wide spectral library. Mol. Cell. Proteomics In press, 10, M111.007666. Oyeyemi, O.A., Sours, K.M., Lee, T., Kohen, A., Resing, K.A., Ahn, N.G. and Klinman, J.P. (2011) Comparative hydrogen-deuterium exchange for a mesophilic vs thermophilic dihydrofolate reductase at 25 °C: Identification of a single active site region with enhanced flexibility in the mesophilic protein. Biochemistry 50, 8251-8260. Meyer-Arendt, K., Old, W.M., Houel, S., Renganathan, K., Eichelberger, B., Resing, K.A., and Ahn, N.G. (2011) IsoformResolver: A peptide-centric algorithm for protein inference. J Proteome Res. 10, 3060-3075. Sours, K.M. and Ahn, N.G. (2010) Analysis of MAP kinases by hydrogen exchange mass spectrometry. In “MAP Kinase Signaling Protocols”, R. Seger, Ed., Methods in Molecular Biology, 661, 239-255. Ring, A.Y., Sours, K.M., Lee, T., and Ahn, N.G. (2010) Distinct patterns of activation-dependent changes in conformational mobility between ERK1 and ERK2. Intl. J. Mass Spectrometry, 302, 101-109. Houel, S., Abernathy, R., Renganathan, K., Meyer-Arendt, K., Ahn, N.G. and Old, W.M. (2010) Quantifying the impact of chimera MS/MS spectra on peptide identification in large scale proteomics studies. J. Proteome Res. 9, 4152-4160. Oyeyemi, O., Sours, K.M., Lee, T., Resing, K.A., Ahn, N.G. and Klinman, J.P. (2010) Temperature dependence of protein motions in a thermophilic dihydrofolate reductase and its relationship to catalytic efficiency. Proc. Natl. Acad. Sci., USA. 107:10074-10079. Kabuyama, Y., Litman, E.S., Templeton, P., Metzner. S.I., Witze, E.S., Argast, G.M., Langer, S.J., Polvinen, K., Shellman, Y, Chan, D., Shabb, J.B., Fitzpatrick, J.E., Resing, K.A., Sousa, M.C., and Ahn, N.G. (2009) A mediator of Rho-dependent signaling in melanoma moonlights as a methionine salvage enzyme. Mol. Cell. Proteomics. 8(10):2308-2320. Argast, G.M., Croy, C.H., Couts, K.L., Zhang, Z., Litman, E.S., Chan, D.C. and Ahn, N.G. (2009) Cross-regulation of plexin B1 by B-Raf signaling in melanoma cells. Oncogene 28(30):2697-2709. Old, W.M., Shabb, J.S., Houel, S., Wang, H., Couts, K.H., Yen, C-Y., Litman, E.S., Croy, C.H, Meyer-Arendt, K., Miranda, J.G., Brown, R.A., Witze, E.S., Schweppe, R.E., Resing, K.A., and Ahn, N.G. (2009) Functional proteomics identifies targets of phosphorylation by B-Raf signaling in melanoma. Molecular Cell, 34(1):115-131. Yen, C.-Y., Meyer-Arendt, K., Eichelberger, B., Houel, S., Old, W.M., Knight, R.D., Ahn, N.G., Hunter, L.E., and Resing, K.A. (2008) A theoretical MS/MS library for spectrum-to-spectrum searching in large-scale identification of proteins. Mol. Cellular Proteomics, 8(4):857-869. Gehrke, A.S., Sun, S., Kurgan, L., Ahn, N., Resing, K., Kafadar, K., and Cios, K. (2008) Improved Machine Learning Method for Analysis of Gas Phase Chemistry of Peptides. BMC Bioinformatics, 9:515. Levin-Salomon, V., Kogan, K., Ahn, N.G., Livnah, O., and Engelberg, D (2008). Isolation of intrinsically active (MEK- independent) variants of the ERK family of MAP kinases. J. Biol. Chem. 283:34500-34510. Sours, K.M., Kwok, S.C., Rachidi, T., Lee, T., Ring, A., Hoofnagle, A.N., Resing, K.A. and Ahn, N.G. (2008) Hydrogen exchange mass spectrometry reveals activation-induced changes in conformational mobility of p38a MAP kinase. J. Mol. Biol., 379(5):1075-1093. Witze, E.S., Litman, E.S., Argast, G.M., Moon, R.T., and Ahn, N.G. (2008) Wnt5A control of cell polarity and directional movement by polarized redistribution of adhesion receptors. Science, 320(5874):365-369. Witze, E.S., Old, W.M., Resing, K.A. and Ahn, N.G. (2007) Mapping protein post-translational modifications with mass spectrometry. Nat. Methods, 4, 798-806. Ahn, N.G., Shabb J.S., Old, W.M., and Resing, K.A. (2007) Achieving in-depth proteomics profiling by mass spectrometry. ACS Chemical Biology, 2:39-52.