马元武 - 中国医学科学院医学实验动物研究所 -

个人简介

学历背景 2006年和2008年在齐鲁工业大学和北京理工大学，分别获得学士和硕士学位，2012年获北京协和医学院博士学位获奖与荣誉 2018年北京市科技奖三等奖（第二完成人） 2018年中国实验动物学会科技奖一等奖（第一完成人） 2016年协和新星 2016年日本实验动物协会国际青年奖 2015年中华医学科技奖三等奖（第五完成人）

研究领域

主要研究方向包括（1）CRISPR/Cas9技术在基因工程动物模型中的应用研究；（2）基于疾病基因工程动物模型的表型分析工作，重点集中在组织干细胞的衰老研究方面。

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

[1]Ma Y, Yu L, Zhang X, Xin C, Huang S, Bai L, Chen W, Gao R, Li J, Pan S, Qi X, huang X*, Zhang L*. Highly efficient and precise base editing by engineered dCas9-guide tRNA adenosine deaminase in rats. Cell Discov. 2018 Jul 17;4:39. doi: 10.1038/s41421-018-0047-9. [2]Liu N, Liu Q, Yang X, Zhang F, Li X, Ma Y, Guan F, Zhao X, Li Z, Zhang L, Ye X.Hepatitis B virus-upregulated lnc-HUR1 promotes cell proliferation and tumorigenesis by blocking p53 activity.Hepatology. 2018 May 23. doi: 10.1002/hep.30098. [3]Jiang M, Zhang S, Yang Z, Lin H, Zhu J, Liu L, Wang W, Liu S, Liu W, Ma Y, Zhang L, Cao X.Self-Recognition of an Inducible Host lncRNA by RIG-I Feedback Restricts Innate Immune Response.Cell. 2018 May 3;173(4):906-919.e13. doi: 10.1016/j.cell.2018.03.064. Epub 2018 Apr 26. [4]Han Y, Liu Q, Hou J, Gu Y, Zhang Y, Chen Z, Fan J, Zhou W, Qiu S, Zhang Y, Dong T, Li N, Jiang Z, Zhu H, Zhang Q, Ma Y, Zhang L, Wang Q, Yu Y, Li N, Cao X.Tumor-Induced Generation of Splenic Erythroblast-like Ter-Cells Promotes Tumor Progression.Cell. 2018 Apr 19;173(3):634-648.e12. doi: 10.1016/j.cell.2018.02.061. Epub 2018 Mar 29. [5]Zheng X, Li Z, Wang G, Li Z, Liang A, Wang H, Dai Y, Huang X, Chen X, Ma Y*, Sun F*.Overexpression of Human-Derived DNMT3A Induced Intergenerational Inheritance of Active DNA Methylation Changes in Rat Sperm.Front Genet. 2017 Dec 12;8:207. doi: 10.3389/fgene.2017.00207. eCollection 2017. (* co-corresponding author) [6]Ma Y*, Zhang L, Huang X*.Building CreKnockin Rat Lines Using CRISPR/Cas9.Methods Mol Biol.2017;1642:37-52. doi: 10.1007/978-1-4939-7169-5_3. (* co-corresponding author) [7]Ma Y, Yu L, Pan S, Gao S, Chen W, Zhang X, Dong W, Li J, Zhou R, Huang L, Han Y, Bai L, Zhang L, Zhang L.CRISPR/Cas9-mediated targeting of the Rosa26 locus produces Cre reporter rat strains for monitoring Cre-loxP-mediated lineage tracing.FEBS J. 2017 Oct;284(19):3262-3277. doi: 10.1111/febs.14188. [8]Xu J, Xu X, Wang B, Ma Y, Zhang L, Xu H, Hu Y, Wu J, Cao X.Nuclear carbonic anhydrase 6B associates with PRMT5 to epigenetically promote IL-12 expression in innate response.Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):8620-8625. doi: 10.1073/pnas.1700917114. [9]WangY, Shi J, Yan J, Xiao Z, Hou X, Lu P, Hou S, Mao T, Liu W, Ma Y, Zhang L, Yang X, and Qi H. Germinal center development of memory B cells driven by Interleukin-9 from follicular T helper cells.Nature Immunology, [10]Chen S, Yang M, Du J, Li D, Li Z, Cai C, Ma Y, Zhang L, Tian Z, Dong Z.The Self-Specific Activation Receptor SLAM Family Is Critical for NK Cell Education.Immunity. 2016 Aug 16;45(2):292-304. [11]Wang W, Jiang M, Liu S, Zhang S, Liu W, Ma Y, Zhang L, Zhang J, Cao X.RNF122 suppresses antiviral type I interferon production by targeting RIG-I CARDs to mediate RIG-I degradation.Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9581-6. [12]Ma Y, Chen W, Zhang X, Yu L, Dong W, Pan S, Gao S, Huang X, Zhang L.Increasing the efficiency of CRISPR/Cas9-mediated precise genome editing in rats by inhibiting NHEJ and using Cas9 protein.RNA Biol. 2016, Jul 2;13(7):605-12. [13]Bao D, Ma Y, Zhang X, Guan F, Chen W, Gao K, Qin C, Zhang L.Preliminary Characterization of a Leptin Receptor Knockout Rat Created by CRISPR/Cas9 System.Sci Rep. 2015 (5): 15942 [14]Ma Y, Zhang X, Shen B, et al. Generating rats with conditional alleles using CRISPR/Cas9. Cell Res, 2014, 24(1): 122-125. [15] Ma Y, Zhang L, and Huang X. Genome modification by CRISPR/Cas9. FEBS J, 2014, 281(23): 5186-5193. [16]Ma Y, Ma J, Zhang X, et al. Generation of eGFP and Creknockin rats by CRISPR/Cas9. FEBS J, 2014, 281(17): 3779-3790. [17]Ma Y, Shen B, Zhang X, et al. Heritable multiplex genetic engineering in rats using CRISPR/Cas9. PLoS One, 2014, 9(3): e89413.

学术兼职

中国比较医学杂志，编委