个人简介
2015年毕业于清华大学细胞生物学专业，获理学博士学位。2015年至今，中国医学科学院医学实验动物研究所助理研究员、副研究员。
研究领域
现主要从事PDX模型的建立及临床前应用研究，包括：（1）建立多种肿瘤（食管癌、胃癌、结直肠癌、肝癌、下咽癌、脑膜瘤等）PDX模型；（2）建立肿瘤PDX模型资源库；（3）筛选敏感化疗药物与癌症个体化治疗研究。
比较医学、实验动物学、肿瘤学、免疫学
近期论文
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1.J Guo, X Qiu, L Zhang, R Wei*. Smurf1 regulates macrophage proliferation, apoptosis and migration via JNK and p38 MAPK signaling pathways. Mol. Immunol. 2018, 97: 20-26.
2.R Wei, B Li, J Guo, M Li, R Zhu, X Yang, R Gao. Smurf1 targets Securin for ubiquitin-dependent degradation and regulates the metaphase-to-anaphase transition. Cell. Signal. 2017, 38:60-66.
3.R Wei, J Guo, M Li, X Yang, R Zhu, H Huang, K Li, L Zhang, Ran Gao. Smurf1 controls S phase progression and tumorigenesis through Wee1 degradation. FEBS Lett. 2017, 591(8):1150-1158.
4.R Wei, X Qiu, S Wang, Y Wang, Y Fu, G Xing, F He, L Zhang. NEDL2 is an essential regulator of enteric neural development and GDNF/Ret signaling. Cell. Signal. 2015, 27(3):578-86.
5.H Huang, Y Han, X Yang, R Zhu, J Hu, X Zhang, R Wei, K Li, R Gao. HNRNPK inhibits gastric cancer cell proliferation through p53/p21/CCND1 pathway. Oncotarget. 2017, 10.18632/oncotarget.21873.
6.X Qiu, R Wei, Y Li, Q Zhu, C Xiong, Y Chen, Y Zhang, K Lu, F He, L Zhang. NEDL2 regulates enteric nervous system and kidney development in its Nedd8 ligase activity-dependent manner. Oncotarget 2016, 7(21): 31440-53
7.Shu J, Liu C, Wei R, Xie P, He S, Zhang L. Nedd8 targets ubiquitin ligase Smurf2 for neddylation and promote its degradation. Biochem. Biophys. Res. Commun. 2016, 474(1):51-6.
8.J Nie*, L Liu*, G Xing*, M Zhang*, R Wei, M Guo, X Li, P Xie, L Li, F He, W Han, L Zhang. CKIP-1 acts as a colonic tumor suppressor by repressing oncogenic Smurf1 synthesis and promoting Smurf1 autodegradation. Oncogene 2014, 33(28):3677-87.
9.L Lu, S Hu, R Wei, X Qiu, K Lu, Y Fu, H Li, G Xing, D Li, R Peng, F He, L Zhang. HECT Type Ubiquitin Ligase NEDL2 is degraded by APC/C-Cdh1 and its Tight Regulation Maintains the Metaphase to Anaphase Transition. J. Biol. Chem. 2013, 288(50): 35637-50.
10.L Zhang*, Y Wang*, F Xiao, S Wang, G Xing, Y Li, X Yin, K Lu, R Wei, J Fan, Y Chen, T Li, P Xie, L Yuan, L Song, L Ma, L Ding, F He, L Zhang. CKIP-1 regulates macrophage proliferation by inhibiting TRAF6-mediated Akt activation. Cell Res. 2014, 24(6):742-61.
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