刘率男 - 中国医学科学院药物研究所 -

个人简介

教育背景 2000年-2005年，沈阳药科大学，药学日语专业，理学学士 2005年-2010年，中国医学科学院药物研究所，抗糖尿病药理学，理学博士工作经历 2010年-2015年，中国医学科学院药物研究所，药理室，助理研究员 2015年-2016年，美国加州大学圣迭戈分校（UCSD），医学院，博士后研究 2016年至今，中国医学科学院药物研究所，药理室，副研究员

研究领域

主要从事糖尿病药理学研究和新药临床前研发工作，涉及2型糖尿病及其慢性并发症相关防治药物的新药靶点研究、筛选模型的建立、先导化合物的发现及药物作用机理的研究，着重胰岛素抵抗、肝糖异生、胰岛β细胞功能及糖尿病及其并发症发生发展的分子机制研究。

近期论文

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刘率男, 刘泉, 孙素娟, 李彩娜, 环奕, 陈跃腾, 汪仁芸, 夏学军, 刘志华, 刘玉玲, 谢明智, 申竹芳*. α-葡萄糖苷酶抑制剂桑枝总生物碱的抗糖尿病作用研究.药学学报2019, 54(7): 1225 −1233 Anfang Cui, Heng Fan, Yinliang Zhang, Yujie Zhang, Dong Niu, Shuainan Liu, Quan Liu, Wei Ma, Zhufang Shen, Lian Shen, Yanling Liu, Huabing Zhang, Yuan Xue, Ying Cui, Qinghua Wang, Xinhua Xiao, Fude Fang, Jichun Yang, Qinghua Cui, and Yongsheng Chang. Dexamethasone-induced Krüppel-like factor 9 expression promotes hepatic gluconeogenesis and hyperglycemia. The Journal of Clinical Investigation 2019.130. pii: 66062.(IF 13.251)， Sirtuin 5 overexpression attenuates glucolipotoxicity-induced pancreatic β cells apoptosis and dysfunction. Yue Wang, Quan Liu, Yi Huan, Rongcui Li, Caina Li, Sujuan Sun, Nan Guo, Miaomiao Yang, Shuainan Liu*, Zhufang Shen*. Experimental Cell Research. 2018, 371, 205-213. (IF: 3.3) Guoning Zhang, Shuainan Liu, Wenjuan Tan, et al. Synthesis and biological evaluations of chalcones, flavones and chromenes as farnesoid x receptor (FXR) antagonists. European Journal of Medicinal Chemistry. 2017.129:303-309. (IF 3.9) Quan Liu, Shuainan Liu, Lihui Gao et al. Anti-diabetic effects and mechanisms of action of a Chinese herbal medicine preparation JQ-R in vitro and in diabetic KKAy mice. Acta Pharmaceutica Sinica B. 2017. 7(4):461–469. 陈致瑜, 刘率男, 罗振华, 孙素娟, 申竹芳, 聂瑛洁. 二甲双胍对高脂饮食诱导的2 型糖尿病小鼠胰岛 β 细胞功能的改善及机制探讨. 药学学报. 2017. 52 (10): 1561 -1567. 王悦, 刘率男, 申竹芳. 线粒体−内质网动态关联与胰岛β 细胞功能稳态. 药学学报. 2017. 52 (5): 667-672. Pingping Li*, Shuainan Liu*, Min Lu*, et al. Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance. Cell. 2016. 167(4):973-984. (并列一作，IF 28.7). Lei Lei, Liu Quan, Liu Shuainan, et al. Antidiabetic potential of a novel dual-target activator of glucokinase and peroxisome proliferator activated receptor-gamma. Metabolism. 2015. 64(10):1250-1261. (IF 3.8). Chunming Jia, Yi Huan, Shuainan Liu, et al. Effect of Chronic Pioglitazone Treatment on Hepatic Gene Expression Profile in Obese C57BL/6J Mice. Int. J. Mol. Sci.2015. (IF 2.8) Jianbo Bie*, Shuainan Liu*, Zhanmei Li, Yongzhao Mu, Bailing Xu, Zhufang Shen. Discovery of novel indole derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase. Eur J Med Chem. 2015. 90:394-405. (并列一作，IF 3.4). 刘率男，刘泉，侯少聪，王悦，申竹芳. 磷酸西格列汀改善2型糖尿病KKAy小鼠糖脂代谢及作用机制探讨.中国临床药理学杂志. 2015. (3): 206-211. 刘率男, 刘泉, 孙素娟, 侯少聪，王悦，申竹芳. 二甲双胍对2型糖尿病KKAy 小鼠胰岛β细胞功能的影响及初步作用机制探讨. 药学学报. 2014. 49 (11):1554-1562. 刘率男, 孙素娟, 刘泉,侯少聪，申竹芳. 木丹颗粒对谷氨酸钠诱导的胰岛素抵抗小鼠胰岛β细胞功能影响的实验研究. 中国中西医结合杂志. 2014. 34(7):853-858. Lihui Gao, Quan Liu, Shuainan Liu, et al. A refined-JinQi-JiangTang tablet ameliorates prediabetes by reducing insulin resistance and improving beta cell function in mice. Journal of Ethnopharmacology. 2014. (IF 2.9) Jianbo Bie, Shuainan Liu, Jie Zhou, Bailing Xu, Zhufang Shen. Design, synthesis and biological evaluation of 7-nitro-1H-indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase. Bioorg Med Chem. 2014. 22(6): 1850-62. (IF 2.9). Linyi Li, Lihui Gao, Shuainan Liu et al. Bis(α-furancarboxylato) oxovanadium(IV) Exerts Durable Antidiabetic Effects and Suppresses Matrix Metalloproteinase-2 Activity in Spontaneous Type 2 Diabetic KKAy Mice. Biol Trace Elem Res. 2013. (IF 1.6) Zhiyu Chen, Shuainan Liu, Caina Li, et al. Atorvastatin helps preserve pancreatic β cell function in obese C57BL/6 J mice and the effect is related to increased pancreas proliferation and amelioration of endoplasmic-reticulum stress. Lipids in Health and Disease. 2013 (IF 2.2). Shuainan Liu, Quan Liu, Sujuan Sun, Qian Jiang, Jun Peng, Zhufang Shen. The application of 2-NBDG as a fluorescent tracer for assessing hepatic glucose production in mice during hyperinsulinemic euglycemic clamp. Acta Pharmaceutica Sinica B. 2012, 2(4): 403-410. Shuainan Liu, Quan Liu, Linyi Li, Yi Huan, Sujuan Sun, Zhufang Shen. Long-term fenofibrate treatment impaired glucose-stimulated insulin secretion and upregulated pancreatic NF-kappa B and iNOS expression in monosodium glutamate-induced obese rats: Is that a latent disadvantage? Journal of Translational Medicine. 2011. 9:176.2. (IF 3.7).