解可波 - 中国医学科学院药物研究所 -

个人简介

教育背景 2006.8—2010.7，山东大学，生命科学学院，生物工程专业，学士 2010.8—2012.7，山东大学，微生物技术国家重点实验室，生物工程专业，硕士 2012.8—2015.7，北京协和医学院，药物研究所，生药学专业，博士工作经历 2015.9—2018.8，中国医学科学院药物研究所，生物合成室，助理研究员 2018.9—至今，中国医学科学院药物研究所，生物合成室，副研究员

研究领域

研究方向为药用天然产物的生物合成与酶法结构修饰。主要研究内容为：1. 解析复杂药用天然产物生物合成途径中的新颖关键酶及其催化机制；2. 利用分子生物学手段，拓宽酶的底物谱，开发工具酶，应用于目标分子的高效酶法合成；3. 构建人工生物合成途径，高效生产活性天然及非天然药物，解决创新药物的来源问题。

近期论文

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1. Kebo Xie, Ridao Chen, Jianhua Li, Ruishan Wang, Dawei Chen, Xiaoxiang Dou, and Jungui Dai*, Exploring the Catalytic Promiscuity of a New Glycosyltransferase from Carthamus tinctorius, Organic Letters, 2014, 16, 4874-4877. (IF 6.56) 2. Kebo Xie, Ridao Chen, Dawei Chen, Jianhua Li, Ruishang Wang, Lin Yang and Jungui Dai*, Enzymatic N-Glycosylation of Diverse Arylamine Aglycones by a Promiscuous Glycosyltransferase from Carthamus tinctorius. Advanced Synthesis & Catalysis, 2017, 359, 603‒608. (IF 5.45) 3. Kebo Xie#, Xiaoxiang Dou#, Ridao Chen, Dawei Chen, Cheng Fang, Zhiyan Xiao and Jungui Dai*, Molecular Characterization and Phylogenetic Analysis of Two Novel Fungal Phenolic UDP-Glycosyltransferases from Absidia coerulea and Rhizopus japonicus. Applied and Environmental Microbiology, 2017, AEM-03103. (IF 3.63) 4. Huili Li#, Kebo Xie#, Wenjun Yu, Liejie Hu, Haiyan Huang, Huijun Xie and Shuning Wang*, Nicotine dehydrogenase complexed with 6-hydroxypseudooxynicotine oxidase involved in the hybrid nicotine-degrading pathway in Agrobacterium tumefaciens S33. Applied and Environmental Microbiology, 2016, 82, 1745‒1755. (IF 3.63，共同一作) 5. Tian Yue, Ridao Chen, Dawei Chen, Jimei Liu, Kebo Xie* and Jungui Dai*, Enzymatic Synthesis of Bioactive O-Glucuronides Using Plant Glucuronosyltransferases, Journal of Agricultural and Food Chemistry, 2019, 67, 6275-6284. (IF 3.41, 共同通讯作者) 6. Kebo Xie, Yujiao Zhang, Ridao Chen, Dawei Chen, Lin Yang, Xia Liu and Jungui Dai*, Enzymatic glucosylation of unnatural naphthols by a promiscuous glycosyltransferase from Aloe arborescens. Tetrahedron Letters, 2017, 58, 2118‒2121. (IF 2.13) 7. Dawei Chen, Ridao Chen, Ruishan Wang, Jianhua Li, Kebo Xie, et al. Probing the catalytic promiscuity of a regio- and stereospecific C-glycosyltransferase from Mangifera indica. Angewandte Chemie International Edition, 2015, 54, 12678‒12682. (IF 12.26)