王宝莲 - 中国医学科学院药物研究所 -

个人简介

教育背景 1999.9～2003.7 山东医科大学药学院药学学士 2003.9～2006.7 军事医学科学院药理学硕士 2006.9～2009.7 中国医学科学院药物研究所药理学博士工作经历 2009.9-至今中国医学科学院药物研究所助理研究员，副研究员

研究领域

1. 新药研发过程中先导物药代特性早期筛选和评价 2. 新药临床前药代动力学研究 3. 药物代谢酶和转运蛋白调控及机制 4. 中药药代动力学研究

近期论文

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1. Fen Yang1, Baolian Wang1, Zhihao Liu, Xuejun Xia, Weijun Wang, Dali Yin, Li Sheng, Yan Li. Prediction of a therapeutic dose for Buagafuran, a potent anxiolytic agent by physiologically based pharmacokinetic/pharmacodynamic modeling starting from pharmacokinetics in rats and human.[J] Frontiers in Pharmacology, 2017, 8:683. doi: 10.3389/fphar.2017.00683. 2. Shuang Yang, Jiaqi Mi, Zhihao Liu, Baolian Wang*, Xuejun Xia, Renyun Wang, Yuling Liu, Yan Li. Pharmacokinetics, tissue distribution and elimination of three active alkaloids in rats after oral administration of the effective fraction of alkaloids from Ramulus Mori, an innovative hypoglycemic agent[J]. Molecules, 2017, 22(10), 1616; doi:10.3390/molecules22101616 3. Baolian Wang, Zhihao Liu, Dan Li, Shuang Yang, Jinping Hu, Hui Chen, Li Sheng, Yan Li. Application of physiologically based pharmacokinetic modeling in the prediction of pharmacokinetics of bicyclol controlled-release formulation in human[J]. European Journal of Pharmaceutical Sciences, 2015, 77: 265-272. 4. Baolian Wang, Shuang Yang, Li Sheng, Yan Li. Simultaneous quantification of curdione, furanodiene and germacrone in rabbit plasma using liquid chromatography–tandem mass spectrometry and its application to a pharmacokinetic study[J]. Biomedical Chromatography, 2015,29（9）:1393-1398. 5. Baolian Wang, Li Sheng, Yan Li. Simultaneous determination of telmisartan and amlodipine in dog plasma by LC-MS-MS[J]. Journal of Chromatographyic Science，2015,53（10）：1708-1713. 6. Baolian Wang, ShuangYang, JinpingHu, YanLi. Multifaceted interaction of the traditional Chinese medicinal herb Schisandra chinensis with cytochrome P450-mediated drug metabolism in rats[J]. Journal of Ethnopharmacology, 2014, 155: 1473–1482. 7. Baolian Wang, Jinping Hu, Li Sheng, Yan Li. Chemical-Pharmacokinetic(PK)- Pharmacodynamic(PD) Fingerprints Study of Schisandra chinensis Alcoholic Extract[J]. Acta Pharmaceutica Sinica. 2013,48(5):734-740. 8. Wei Tan1, Baolian Wang 1, Jinping Hu, Li Sheng, Yan Li. Establishment of a liquid chromatography/mass spectrometry for determination of bicyclol in rat single-pass intestinal perfusion[J]. Biomedical Chromatography, 2009, 23(10)：1059-1063. 9. Baolian Wang, Jinping Hu, Wei Tan, Li Sheng, Hui Chen, Yan Li. Simultaneous quantification of four active schisandra lignans from a traditional Chinese medicine Schisandra chinensis(Wuweizi) in rat plasma using liquid chromatography/mass spectrometry[J]. Journal of Chromatography B, 2008, 865(1-2):114–120. 10. Yufei Jia, Baolian Wang, Xiangmeng Wu, Sheng Li, Jinping Hu, Dongmei Wang，Haibo Zhu, Yan Li. Simultaneous quantification of 2,3,5-tri-O- acetyl-N6-(3-hydroxylaniline)adenosine and its principal metabolites in hamster blood by LC–MS/MS and its application in pharmacokinetics study[J]. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 2016, 1022：46-53. 11. Shuang Yang, Baolian Wang, Xuejun Xia, Xue Li, Renyun Wang, Li Sheng, Dan Li, Yuling Liu, Yan Li. Simultaneous quantification of three active alkaloids from atraditional Chinese medicine Ramulus Mori (Sangzhi) in rat plasma using liquid chromatography-tandem mass spectrometry[J]. Journal of Pharmaceutical and Biomedical Analysis，2015, 109：177-183.