个人简介
教育背景
2009.9−2012.7 中国医学科学院药物研究所,生药学,博士
2006.9−2009.7 沈阳药科大学,中药学,硕士
2002.9−2006.7 沈阳药科大学,药学,学士
工作经历
2017.9−至今,中国医学科学院药物研究所,副研究员
2012.9−2017.9,中国医学科学院药物研究所,助理研究员
研究领域
研究方向为药用天然产物的生物合成,主要致力于天然产物生物合成关键酶的分子机制及天然药物的酶法合成研究。
近期论文
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1. Ridao Chen#, Bingquan Gao#, Xiao Liu#, Feiying Ruan, Yong Zhang, Jizhong Lou, Keping Feng, Carsten Wunsch, Shu-Ming Li, Jungui Dai*, Fei Sun*. Molecular insights into the enzyme promiscuity of an aromatic prenyltransferase. Nature Chemical Biology, 2017, 13, 226−234. (IF: 13.843)
2. Ridao Chen, Xiao Liu, Jianhua Zou, Yunze Yin, Bin Ou, Jianhua Li, Ruishan Wang, Dan Xie, Peicheng Zhang, Jungui Dai*. Regio- and stereospecific prenylation of flavonoids by Sophora flavescens prenyltransferase. Advanced Synthesis & Catalysis, 2013, 355, 1817−1828. (IF: 5.542)
3. Jianhua Li#, Ridao Chen#, Ruishan Wang, Xiao Liu, Kebo Xie, Dawei Chen, Jungui Dai*. Biocatalytic access to diverse prenylflavonoids by combining a regiospecific C-prenyltransferase and a stereospecific chalconeisomerase. Acta Pharmaceutica Sinica B, https://doi.org/10.1016/j.apsb.2018.01.009. (IF: 6.014)
4. Ridao Chen, Xiao Liu, Jianhua Zou, Lin Yang, Jungui Dai*. Qualitative and quantitative analysis of phenylpropanoids in cell culture, regenerated plantlets and herbs of Saussurea involucrata. Journal of Pharmaceutical and Biomedical Analysis, 2013, 74, 39−46. (IF: 2.829)
5. Ridao Chen, Zheng Yan, Jianhua Zou, Nan Wang, Jungui Dai*. Rubratoxin C, a new nonadride derivative from an endophytic fungus Penicillium sp. F-14. Chinese Chemical Letters, 2014, 25, 1308−1310. (IF: 1.587)
6. Ridao Chen, Ruigang Duan, Yannan Wei, Jianhua Zou, Junwei Li, Xiaoyue Liu, Haiyan Wang, Ying Guo, Qiuhong Li, Jungui Dai*. Flavonol dimers from callus cultures of Dysosma versipellis and their in vitro neuraminidase inhibitory activities. Fitoterapia, 2015, 107, 77−84. (IF: 2.408)
7. Kebo Xie, Ridao Chen, Dawei Chen, Jianhua Li, Ruishan Wang, Lin Yang, Jungui Dai*. Enzymatic N-glycosylation of diverse arylamine aglycons by a promiscuous glycosyltransferase from Carthamus tinctorius. Advanced Synthesis & Catalysis, 2017, 359, 603−608. (IF: 5.123)
8. Kebo Xie, Ridao Chen, Jianhua Li, Ruishan Wang, Dawei Chen, Xiaoxiang Dou, Jungui Dai*. Exploring the catalytic promiscuity of a new glycosyltransferase from Carthamus tinctorius. Organic Letters, 2014, 16, 4874−4877. (IF: 6.364)
9. Ruishan Wang, Ridao Chen, Jianhua Li, Xiao Liu, Kebo Xie, Dawei Chen, Yunze Yin, Xiaoyu Tao, Dan Xie, Jianhua Zou, Lin Yang, Jungui Dai*. Molecular characterization and phylogenetic analysis of two novel regio-specific flavonoid prenyltransferases from Morus alba and Cudrania tricuspidata. The Journal of Biological Chemistry, 2014, 289, 35815−35825. (IF: 4.573)
10. Jianhua Li, Ridao Chen, Ruishan Wang, Xiao Liu, Dan Xie, Jianhua Zou, Jungui Dai*. GuA6DT, a regiospecific prenyltransferase from Glycyrrhiza uralensis, catalyzes the 6-prenylation of flavones. ChemBioChem, 2014, 15, 1673−1681. (IF: 3.088)
11. 陈日道, 刘晓, 邹建华, 杨林, 戴均贵*. 天山雪莲悬浮培养细胞中紫丁香苷、绿原酸和1,5-二咖啡酰奎尼酸的生物合成调控. 中国中药杂志, 2014, 39, 2275−2280.