来芳芳 - 中国医学科学院药物研究所 -

个人简介

教育背景 2003.9-2007.7 浙江大学药学院陈海亮辅导员本科/理学学士 2007.9-2012.7 北京协和医学院医药生物技术研究所司书毅研究员博士（直博）/医学博士 2010.5-2012.5 美国托莱多大学 Zijian Xie 教授交流访问工作经历 2012.8-2016.7 中国医学科学院药物研究所陈晓光研究员课题组助理研究员 2016.7-至今中国医学科学院药物研究所药理系副高级研究员

研究领域

主要从事肿瘤和肿瘤免疫学的药理学研究及相应的新药临床前开发。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

[1] Y. He, J. Wen, Q. Cui, F. Lai, D. Yin, H. Cui, Quantitative Evaluation of in Vivo Target Efficacy of Anti-tumor Agents via an Immunofluorescence and EdU Labeling Strategy, Front Pharmacol, 9 (2018) 812. [2] F. Lai, N. Madan, Q. Ye, Q. Duan, Z. Li, S. Wang, S. Si, Z. Xie, Identification of a mutant alpha1 Na/K-ATPase that pumps but is defective in signal transduction, J Biol Chem, 288 (2013) 13295-13304. [3] Q. Ye, F. Lai, M. Banerjee, Q. Duan, Z. Li, S. Si, Z. Xie, Expression of mutant alpha1 Na/K-ATPase defective in conformational transition attenuates Src-mediated signal transduction, J Biol Chem, 288 (2013) 5803-5814. [4] F. Lai, Q. Liu, X. Liu, M. Ji, P. Xie, X. Chen, LXY6090 - a novel manassantin A derivative - limits breast cancer growth through hypoxia-inducible factor-1 inhibition, Onco Targets Ther, 9 (2016) 3829-3840. [5] F. Lai, Z. Shen, H. Wen, J. Chen, X. Zhang, P. Lin, D. Yin, H. Cui, X. Chen, A Morphological identification cell cytotoxicity assay using cytoplasm-localized fluorescent probe (CLFP) to distinguish living and dead cells, Biochem Biophys Res Commun, 482 (2017) 257-263. [6] Y. Xu, Q. Liu, Y. Xu, C. Liu, X. Wang, X. He, N. Zhu, J. Liu, Y. Wu, Y. Li, N. Li, T. Feng, F. Lai, M. Zhang, B. Hong, J.D. Jiang, S. Si, Rutaecarpine suppresses atherosclerosis in ApoE-/- mice through upregulating ABCA1 and SR-BI within RCT, J Lipid Res, 55 (2014) 1634-1647. [7] M. Ji, L. Wang, J. Chen, N. Xue, C. Wang, F. Lai, R. Wang, S. Yu, J. Jin, X. Chen, CAT3, a prodrug of 13a(S)-3-hydroxyl-6,7-dimethoxyphenanthro[9,10-b]-indolizidine, circumvents temozolomide-resistant glioblastoma via the Hedgehog signaling pathway, independently of O(6)-methylguanine DNA methyltransferase expression, Onco Targets Ther, 11 (2018) 3671-3684. [8] M. Ji, L. Wang, N. Xue, F. Lai, S. Zhang, J. Jin, X. Chen, The Development of a Biotinylated NAD(+)-Applied Human Poly(ADP-Ribose) Polymerase 3 (PARP3) Enzymatic Assay, SLAS Discov, 23 (2018) 545-553. [9] N. Yan, Y. He, H. Wen, F. Lai, D. Yin, H. Cui, A Suzuki-Miyaura method for labelling proliferating cells containing incorporated BrdU, Analyst, 143 (2018) 1224-1233. [10] F. Niu, Y. Li, F.F. Lai, X.G. Chen, [Research progress of hypoxia-inducible factor 1 inhibitors against tumors], Yao Xue Xue Bao, 49 (2014) 832-836. [11] J. Miao, H. Cui, J. Jin, F. Lai, H. Wen, X. Zhang, G.F. Ruda, X. Chen, D. Yin, Development of 3-alkyl-6-methoxy-7-hydroxy-chromones (AMHCs) from natural isoflavones, a new class of fluorescent scaffolds for biological imaging, Chem Commun (Camb), 51 (2015) 881-884. [12] Y. Wang, Q. Ye, C. Liu, J.X. Xie, Y. Yan, F. Lai, Q. Duan, X. Li, J. Tian, Z. Xie, Involvement of Na/K-ATPase in hydrogen peroxide-induced activation of the Src/ERK pathway in LLC-PK1 cells, Free Radic Biol Med, 71 (2014) 415-426. [13] H. Wen, Q. Cui, H. Meng, F. Lai, S. Wang, X. Zhang, X. Chen, H. Cui, D. Yin, A high-resolution method to assess cell multinucleation with cytoplasm-localized fluorescent probes, Analyst, 141 (2016) 4010-4013. [14] N. Xue, Q. Zhou, M. Ji, J. Jin, F. Lai, J. Chen, M. Zhang, J. Jia, H. Yang, J. Zhang, W. Li, J. Jiang, X. Chen, Chlorogenic acid inhibits glioblastoma growth through repolarizating macrophage from M2 to M1 phenotype, Sci Rep, 7 (2017) 39011. [15] L. Yan, F. Lai, X. Chen, Z. Xiao, Discovery of novel indirubin-3'-monoxime derivatives as potent inhibitors against CDK2 and CDK9, Bioorg Med Chem Lett, 25 (2015) 2447-2451. [16] S. Zhang, D. Wang, N. Xue, F. Lai, M. Ji, J. Jin, X. Chen, Nicousamide protects kidney podocyte by inhibiting the TGFbeta receptor II phosphorylation and AGE-RAGE signaling, Am J Transl Res, 9 (2017) 115-125. [17] H. Zhao, M. Ji, G. Cui, J. Zhou, F. Lai, X. Chen, B. Xu, Discovery of novel quinazoline-2,4(1H,3H)-dione derivatives as potent PARP-2 selective inhibitors, Bioorg Med Chem, 25 (2017) 4045-4054. [18] A. Zhou, L. Yan, F. Lai, X. Chen, M. Goto, K.H. Lee, Z. Xiao, Design, synthesis and biological evaluation of novel indolin-2-ones as potent anticancer compounds, Bioorg Med Chem Lett, 27 (2017) 3326-3331. [19] Y. Xu, F. Lai, Y. Xu, Y. Wu, Q. Liu, N. Li, Y. Wei, T. Feng, Z. Zheng, W. Jiang, L. Yu, B. Hong, S. Si, Mycophenolic acid induces ATP-binding cassette transporter A1 (ABCA1) expression through the PPARgamma-LXRalpha-ABCA1 pathway, Biochem Biophys Res Commun, 414 (2011) 779-782. [20] F. Niu, Y. Li, F.F. Lai, L. Ni, M. Ji, J. Jin, H.Z. Yang, C. Wang, D.M. Zhang, X.G. Chen, LB-1 Exerts Antitumor Activity in Pancreatic Cancer by Inhibiting HIF-1alpha and Stat3 Signaling, J Cell Physiol, 230 (2015) 2212-2223.