个人简介
教育背景
2004.08－2007.07，北京大学医学部，病理生理学，博士
2001.08－2004.07，重庆医科大学，病理学，硕士
1996.09－2001.07，三峡大学医学院，临床医学，学士
工作经历
2016.06－至今，中国医学科学院药物研究所，副研究员/课题组长
2015.12－2016.05，首都医科大学附属北京安贞医院，副研究员/副教授
2014.11－2015.11，美国匹兹堡大学医学中心病理系，访问学者
2013.11－2014.11，首都医科大学附属北京安贞医院，副研究员
2009.10－2013.10，首都医科大学附属北京安贞医院，助理研究员
2008.11－2009.09，首都医科大学附属北京安贞医院，实习研究员
2007.07－2008.10，首都医科大学附属北京安贞医院，病理住院医师
研究领域
主要研究方向为免疫药理学及分子药理学，包括肿瘤免疫微环境与抗癌药靶研究，非可控性炎症反应参与心血管重塑相关疾病的分子靶点研究，前沿病理技术、小动物活体分子影像技术对动物疾病模型的评价及药理学研究。
近期论文
查看导师新发文章
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[1] Gan W, Ren J, Li T, Lv S, Li C, Liu Z, Yang M*. The SGK1 inhibitor EMD638683, prevents Angiotensin II-induced cardiac inflammation and fibrosis by blocking NLRP3 inflammasome activation. Biochim Biophys Acta-Mol Basis Dis. 2018;1864(1):1-10. （IF:5.476）
[2] Min Yang, Bo Ma, Hanshuang Shao, Amanda M. Clark, Alan Wells. Macrophage phenotypic subtypes diametrically regulate epithelial-mesenchymal plasticity in breast cancer cells. BMC Cancer. 2016; 16: 419. doi: 10.1186/s12885-016-2411-1 （IF:3.288）
[3] Yang M#, Liu J#, Piao C, Shao J, Du J*. ICAM-1 suppresses tumor metastasis by inhibiting macrophage M2 polarization through blockade of efferocytosis. Cell Death & Disease. 2015 Jun 11;6:e1780. （IF:5.965）
[4] Yang M, Shao JH, Miao YJ, Cui W, Qi YF, Han JH, Lin X, Du J*. Tumor cell-activated CARD9 signaling contributes to metastasis-associated macrophage polarization. Cell Death & Differentiation. 2014; 21(8):1290-1302.（IF:8.339）
[5] Yang M#, Liu J#, Shao J, Qin Y, Ji Q, Zhang X, Du J*. Cathepsin S-mediated autophagic flux in tumor-associated macrophages accelerate tumor development by promoting M2 polarization. Molecular Cancer. 2014 Mar 2;13:43. doi:10.1186/1476-4598-13-43. （IF:6.204）
[6] Zheng J#, Yang M# (Co-first author), Shao J, Miao Y, Han J, Du J*. Chemokine receptor CX3CR1 contributes to macrophage survival in tumor metastasis. Molecular Cancer. 2013 Nov 18;12(1):141. doi: 10.1186/1476-4598-12-141. （IF:6.204）
[7] Min Yang, Jiao Zheng, Yanjv Miao, Ying Wang, Wei Cui, Jun Guo, Shulan Qiu, Yalei Han, Lixin Jia, Huihua Li, Jizhong Cheng, Jie Du*.Serum-glucocorticoid regulated kinase 1 regulates alternatively activated macrophage polarization contributing to angiotensin II-induced inflammation and cardiac fibrosis. Arteriosclerosis Thrombosis & Vascular Biology. 2012; 32:1675-1686. （IF:6.607）
[8] Min Yang, Sheng-di Hu, Bin Wu, Yan-ying Miao, Hui Pan, Shi-gong Zhu*. Ghrelin inhibits apoptosis signal-regulating kinase 1 activity via upregulating heat shock protein 70. Biochemical and Biophysical Research Communications. 2007; 359:373-378. （IF:2.466）
[9] Jia L, Zhang W, Ma Y, Chen B, Liu Y, Piao C, Wang Y, Yang M, Liu T, Zhang J, Li T, Nie S, Du J. Haplodeficiency of Ataxia Telangiectasia Mutated Accelerates Heart Failure After Myocardial Infarction. J Am Heart Assoc. 2017 Jul 19;6(7). pii: e006349.
[10] Ma B, Wheeler SE, Clark AM, Whaley DL, Yang M, Wells A. Liver Protects Metastatic Prostate Cancer From Induced Death by Activating E-cadherin Signaling. Hepatology. 2016 Aug 2. doi: 10.1002/hep.28755.
[11] Wu XF, Yang M, Qu AJ, Mintz GS, Yang Y, Shang YP, Gao H, Zhang YC, Ge CJ, Wang LY, Wang L, Pu J. Level of Pregnancy-associated Plasma Protein-A Correlates With Coronary Thin-cap Fibroatheroma Burden in Patients With Coronary Artery Disease: Novel Findings From 3-Vessel Virtual Histology Intravascular Ultrasound Assessment. Medicine (Baltimore). 2016 Jan;95(3):e2563. doi: 10.1097/MD.0000000000002563.
[12] Xi X, Liu S, Shi H, Yang M, Qi Y, Wang J, Du J*. Serum-Glucocorticoid Regulated Kinase 1 Regulates Macrophage Recruitment and Activation Contributing to Monocrotaline-Induced Pulmonary Arterial Hypertension. Cardiovascular Toxicology. 2014, 14(4):368-378
[13] Jia LX, Qi GM, Liu O, Li TT, Yang M, Cui W, Zhang WM, Qi YF, Du J*. Inhibition of platelet activation by clopidogrel prevents hypertension-induced cardiac inflammation and fibrosis. Cardiovascular Drugs & Therapy. 2013; 27(6):521-30.
[14] Juan Lin#; Hanjie Li#; Min Yang; Junming Ren; Zhe Huang; Felicia Han; Jian Huang; Jianhui Ma; Duanwu Zhang; Zhirong Zhang; Jianfeng Wu; Deli Huang; Muzhen Qiao;Guanghui Jin; Qiao Wu; Yinghui Huang; Jie Du*, Jiahuai Han*. A role of RIP3-mediated macrophage necrosis in atherosclerosis development. Cell Reports. 2013; 3:200-210.
[15] Jingyuan Ren, Min Yang, Guanming Qi, Jiao Zheng, Lixin Jia, Jizhong Cheng , Cui Tian, Huihua Li, Xin Lin and Jie Du*. Proinflammatory protein CARD9 is essential for infiltration of monocytic fibroblast precursors and cardiac fibrosis caused by angiotensin II infusion. American Journal of Hypertension. 2011; 24: 701-707.
[16] Wu X, Cheng J, LiP, Yang M, Qiu S, Liu P, Du,J* Mechano-sensitive transcriptional factor Egr-1 regulates insulin-like growth factor-1 receptor expression and contributes to neointima formation in vein grafts. Arteriosclerosis Thrombosis & Vascular Biology. 2010; 30: 471-476.
[17] Cheng J, Wang Y, Ma Y, Chan BT, Yang M, Liang A, Zhang L, Li H, Du J*. The mechanical stress-activated serum-, glucocorticoid-regulated kinase 1 contributes to neointima formation in vein grafts. Circulation Research. 2010; 107:1265-1274.
[18] Bin Wu, Sheng-di Hu, Min Yang, Hui Pan, Shi-gong Zhu*. CART peptide promotes the survival of hippocampal neurons by upregulating brain-derived neurotrophic factor. Biochemical and Biophysical Research Communications. 2006: 347: 656-661.
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