个人简介

教育背景 2008.9 – 2011.7 北京协和医学院，药物化学，博士 2003.9 – 2006.7 江西中医药大学，中药学，硕士 1999.9 – 2003.7 江西中医药大学，中药学，学士 工作经历 2014.8 – 至今 中国医学科学院药物研究所，助理研究员、副研究员 2011.10 – 2014.6 北京大学药学院，博士后 2006.8 – 2008.8 中国科学院广州生物医药与健康研究院

研究领域

主要从事药用活性天然产物的发现及其合成生物学研究。

1. 基因组导向的活性天然产物的发现：针对特殊生境微生物（植物内生真菌、海洋来源真菌），在基因组生物信息学分析的基础上，利用多种生物学技术激活其中的沉默基因，发现其特殊生境下的活性化合物 2. 药用活性天然产物的生物合成与结构修饰：针对新颖结构的活性分子，解析其生物合成途径，发现并累积特殊功能的酶，利用合成生物学技术对其进行结构修饰，为新药研制提供先导化合物

近期论文

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1. Jian Bai, Rong Mu, Man Dou, Daojiang Yan, Bingyu Liu, Qian Wei, Jun Wan, Yi Tang, Youcai Hu*. Epigenetic modification in histone deacetylase deletion strain of Calcarisporium arbuscula leads to diverse diterpenoids. Acta Pharmaceutica Sinica B, 2018, 8, 687-697. (IF: 5.808) 2. Jian Bai#, Daojiang Yan#, Tao Zhang, Yongzhi Guo, Yunbao Liu, Yi Zou, Mancheng Tang, Bingyu Liu, Qiong Wu, Shishan Yu*, Yi Tang*, Youcai Hu*. A Cascade of Redox Reactions Generates Complexity in the Biosynthesis of the Protein Phosphatase-2 Inhibitor Rubratoxin A. Angewandte Chemie International Edition, 2017, 56, 4782-4786. (IF: 12.102) 3. Jian Bai, Dong Liu, Siwang Yu, Peter Proksch, Wenhan Lin*. Amicoumacins from the marine-derived bacterium Bacillus sp. with the inhibition of NO production. Tetrahedron Letters, 2014, 55, 6286-6291. (IF: 2.391) 4. Jian Bai, Hui Chen, Zhen-Feng Fang, Shi-Shan Yu*, Wen-Jie Wang, Yang Liu, Shuang-Gang Ma, Yong Li, Jing Qu, Song Xu, Jun-Hong Liu, Fen Zhao, Nan Zhao. Sesquiterpenes from the roots of Illicium dunnianum. Phytochemistry, 2012, 80, 137-147. (IF: 3.05) 5. Jian Bai, Zhen-Feng Fang, Hui Chen, Shi-Shan Yu*, Dan Zhang, Huai-Ling Wei, Shuang-Gang Ma, Yong Li, Jing Qu, Song Xu, Jing-Hong Ren, Fen Zhao, Nan Zhao, Jun-Hong Liu. Antioxidant phenolic glycosides from the roots of Illicium dunnianum. Carbohydrate Research, 2012, 361, 206-211. (IF 2.044) 6. Jian Bai, Hui Chen, Zhen-Feng Fang, Shi-Shan Yu*, Shuang-Gang Ma, Yong Li, Jing Qu, Song Xu, Jing-Hong Ren, Hai-Ning Lv, Xia Chen. Sesquiterpenes and neolignans from the roots of Illicium dunnianum. Journal of Asian Natural Products Research, 2012, 14, 940-949. (IF 0.948) 7. Qibin Chen#, Jie Gao#, Cooper Jamieson, Jiawang Liu, Masao Ohashi, Jian Bai, Daojian Yan, Bingyu Liu, Yongsheng Che, Yanan Wang, K. N. Houk*, and Youcai Hu*. Enzymatic Intermolecular Hetero-Diels−Alder Reaction in the Biosynthesis of Tropolonic Sesquiterpenes. Journal of the American Chemical Society, 2019, 141(36), 14052-14056. (IF 14.357) 8. Daojiang Yan#, Qibin Chen#, Jie Gao#, Jian Bai, Bingyu Liu, Yalong Zhang, Le Zhang, Chen Zhang, Yi Zou, Youcai Hu*, Complexity and Diversity Generation in the Biosynthesis of Fumiquinazoline-Related Peptidyl Alkaloids. Organic Letters, 2019, 21 (5), 1475-1479. (IF: 6.492) 9. Tao Zhang#, Jun Wan#, Zhajun Zhan, Jian Bai, Bingyu Liu, Youcai Hu*. Activation of an Unconventional Meroterpenoid Gene Cluster in Neosartorya glabra Leads to the Production of New Berkeleyacetals. Acta Pharmaceutica Sinica B, 2018, 8(3), 478-487. (IF: 5.808) 10. Ya-Nan Wang#, Yan-Hua Mou#, Yu Dong#, Yan Wu, Bing-Yu Liu, Jian Bai, Dao-Jiang Yan, Le Zhang, Dan-Qing Feng, Yue-Hu Pei*, and You-Cai Hu*. Diphenyl Ethers from a Marine-Derived Aspergillus sydowii. Marine Drugs, 2018, 16, 451-461. (IF: 3.772) #co-first author; *Corresponding author.