个人简介
教育背景
1992-1996 复旦大学上海医学院 理学士
2000-2003 北京协和医学院 药学硕士
2014-2017 北京协和医学院 医学博士
工作经历
1998.1- 中国医学科学院北京协和医学院药物研究所
1996.8-1998.1 中国医学科学院北京协和医学院医药生物技术研究所
研究领域
研究方向为新药研发、靶向药物递送系统研究及小分子药物作用机制研究。
1、靶向药物递送
2、肿瘤靶向治疗
3、纳米药物给药系统
4、小核酸治疗及递送
近期论文
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1. Lu-Lu Wang, Chen-Lin Feng, Wen-Sheng Zheng, Shuai Huang, Wen-Xuan Zhang,Hong-Na Wu, Yun Zhan, Yan-Xing Han, Song Wu , Jian-Dong Jiang. Tμmor-selective lipopolyplex encapsμlated small active RNA hamperscolorectal cancer growth in vitro and in orthotopic murine. Biomaterials, 2017, 141:13-28. IF:8.4
2. Lu-Lu Wang, Hui-Hui Guo, Yun Zhan, Chen-Lin Feng, Shuai Huang, Yan-Xing Han, Wen-Sheng Zheng, Jian-Dong Jiang. Specific up-regμlation of p21 by a small active RNA sequence suppresses hμman colorectal cancer growth. Oncotarget, 2017, 8, (15): 25055-25065.IF:5.16
3. Lu-Lu Wang, Shao-Hua Chen, Wen-Sheng Zheng, Yan-Xing Han, Jian-Dong Jiang. Development of rectal delivered thermo-reversible gelling film encapsμlating a 5-fluorouracil hydroxypropyl -B-cyclodextrin complex. Carbonhydrate Polymers, 2016, 137: 9-18. IF:4.88
4. Lu-Lu Wang, Shuai Huang, Hui-Hui Guo, Yan-Xing Han, Jian-Dong Jiang. In-situ delivery of thermo-sensitive gel-mediated 5-fluorouracil micro emμlsion for the treatment of colorectal cancer. Drμg design, Development and Therapy, 2016, 10: 2855-2867.IF:2.8
5. Lu-Lu Wang *, Hui-Hui Guo*, Shuai Huang*, Chen-Lin Feng, Yan-Xing Han, Jian-Dong Jiang. Comprehensive evaluation of SCFA production in the intestinal bacteria regμlated by berberine using gas-chromatography combined with polymerase chain reaction. Journal of Chromatography B,2017, 1057: 70–80. IF: 2.6
6. Chen-Lin Feng, Yan-Xing Han, Hui-Hui Guo, Xiao-Lei Ma, Lu-Lu Wang*, Wen-Sheng Zheng*, Jian-Dong Jiang*. Hyaluronic acid based self-assembling HA/PEI/dsRNA-p21 ternary complexes for CD44 mediated RNA delivery to colorectal cancer cells. Submitted.
7. Lu-Lu Wang, Wen-Sheng Zheng, Shao-Hua Chen, Li Xiang. Development of in situ gelling and bio adhesive 5 -Fluorouracil enema. PLoSONE www.plosone.org/2013,8(8):1-10. IF:2.9
8. 王璐璐, 郭慧慧,黄帅,韩燕星*.氟脲嘧啶-羟丙基-B-环糊精包合物的生物黏附凝胶剂的制备与评价.中国新药杂志,2017,26(5):103-108.
9. 王璐璐, 郭慧慧,郑稳生,陈少华,韩燕星*.温度敏感凝胶介导的氟尿嘧啶复乳经Caco2细胞模型的转运吸收研究.中国药师,2016,19(9):1641-1643.
10. 王璐璐,陈少华,相莉,郑稳生.5-氟尿嘧啶微乳原位凝胶的溶出度研究.医药导报,2015,34(1):11-14.
11. 王璐璐,陈少华,相莉,郑稳生.5-氟尿嘧啶直肠敏温胶膜剂的研制.中国药房,2015,26(1):06-108.
12. 王璐璐,陈少华,相莉,张秀立,郑稳生.氟尿嘧啶-羟丙基-β-环糊精包合物温敏凝胶生物黏附力及溶出度研究.中国药师,2014,17(12):2040-2442.
13. 王璐璐,陈少华,相莉,张秀立,郑稳生.高效液相色谱法测定5-氟尿嘧啶复乳原位凝胶的含量,中国药业,2014,23(22):53-54.
14. 王璐璐,陈少华,相莉,郑稳生.门冬氨酸鸟氨酸注射液的处方与工艺优化研究,中国医药指南,2014,(36):51-52.
15. 棓丙酯-羟丙基-β-环糊精包合物的研制,中国新药杂志,2013,22(11):1337-1340
16. 不同方法处理的头孢克肟的表征与溶出行为研究,医药导报,2013,32(5):667-669
17. HPLC法测定氟尿嘧啶-羟丙基-β -环糊精包合物温敏凝胶剂的含量,中国药师,2013,16(5):665-667
18. 高效液相色谱法测定氟尿嘧啶液体栓剂含量,医药导报,2013,32(2):251-252
19. 不同粒度头孢克肟胶囊的体外溶出度,中国药师,2012,15:S97-S98
20. 高效液相色谱法测定门冬氨酸鸟氨酸注射液的含量,医药导报,2012,31(12):1621-1623