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个人简介

2006.09 – 2009.07 北京协和医学院,药理学专业,理学博士 2009.09 – 2013.07 军事医学科学院毒物药物研究所,博士后 2013.08 – 至今 中国医学科学院药物研究所,助理研究员、副研究员

研究领域

神经精神药理学研究方向,目前主要集中在对抑郁症新的发病机制和新的药物靶标的探究和解析,以及抗抑郁创新药物的药理学研究方面。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Li G*, Li GY, Wang ZZ, Ji HJ, Wang DM, Hu JF, Yuan YH, Liu G, Chen NH*. The chemokine-like factor 1 induces asthmatic pathological change by activating nuclear factor-kappaB signaling pathway. International Immunopharmacology, 2014; 20(1): 81-88. Wang ZZ, Zhang Y, Liu YQ, Zhao N, Zhang YZ, Yuan L, An L, Li J, Wang XY, Qin JJ, Wilson SP, O’Donnell JM, Zhang HT, Li YF*. RNA interference-mediated phosphodiesterase-4D splice variants knockdown in the prefrontal cortex produces antidepressant-like and cognition-enhancing effects. British Journal of Pharmacology, 2013; 168: 1001-1014. Kong LL, Wang ZY, Han N, Zhuang XM, Wang ZZ, Li H*, Chen NH*. Neutralization of chemokine-like factor 1, a novel C-C chemokine, protects against focal cerebral ischemia by inhibiting neutrophil infiltration via MAPK pathways in rats. Journal of Neuroinflammation, 2014; 11: 112. Xia CY, Zhang S, Gao Y, Wang ZZ, Chen NH*. Selective modulation of microglia polarization to M2 phenotype for stroke treatment. International Immunopharmacology, 2015; 25: 377-382. Zhang Z, Chu SF, Mou Z, Gao Y, Wang ZZ, Wei GN, Chen NH*. Ganglioside GQ1b induces dopamine release through the activation of Pyk2. Molecular and Cellular Neuroscience, 2016; 71: 102-113. Gao Y, Chu SF, Li JP, Zhang Z, Yan JQ, Wen ZL, Xia CY, Mou Z, Wang ZZ, He WB, Guo XF, Wei GN, Chen NH*. Protopanaxtriol protects against 3-nitropropionic acid-induced oxidative stress in a rat model of Huntington's disease. Acta Pharmacologica Sinica, 2015; 36: 311-322. Wang ZZ, Yang WX, Zhang Y, Zhao N, Zhang YZ, Liu YQ, Xu Y, Wilson SP, O’Donnell JM, Zhang HT, Li YF*. Phosphodiesterase-4D Knock-down in the Prefrontal Cortex Alleviates Chronic Unpredictable Stress-Induced Depressive-Like Behaviors and Memory Deficits in Mice. Scientific Reports, 2015; 5: 11332. Wang ZZ, Zhang Y, Zhang HT, Li YF*. Phosphodiesterase (PDEs): An interface connecting cognitive deficits to neuropsychiatric and neurodegenerative diseases. Current Pharmaceutical Design, 2015; 21: 303-316. Zhang Y*, Gong XG, Wang ZZ, Sun HM*, Guo ZY, Hu JH, Ma L, Li P, Chen NH. Overexpression of DJ-1/PARK7, the Parkinson's disease-related protein, improves mitochondrial function via Akt phosphorylation on threonine 308 in dopaminergic neuron-like cells. European Journal of Neuroscience, 2016; 43(10): 1379-1388. Zhang Y*, Gong XG, Wang ZZ, Sun HM*, Guo ZY, Gai C, Hu JH, Ma L, Li P Chen NH*. Protective effects of DJ-1 medicated Akt phosphorylation on mitochondrial function are promoted by Da-Bu-Yin-Wan in 1-methyl-4-phenylpyridinium-treated human neuroblastoma SH-SY5Y cells. Journal of Ethnopharmacology, 2016; 187: 83-93. Xia CY, Zhang S, Chu SF, Wang ZZ, Song XY, Zuo W, Gao Y, Yang PF, Chen NH*. Autophagic flux regulates microglial phenotype according to the time of oxygen-glucose deprivation/reperfusion. International Immunopharmacology, 2016; 39: 140-148. Zhou H, Xue W, Chu SF, Wang ZZ, Li CJ, Jiang YN, Luo LM, Luo P, Li G, Zhang DM and Chen NH*. Polygalasaponin XXXII, a triterpenoid saponin from Polygalae Radix, attenuates scopolamine-induced cognitive impairments in mice. Acta Pharmacologica Sinica, 2016; 37(8): 1045-1053. Zhang XL, Yuan YH, Shao QH, Wang ZZ, Zhu CG, Shi JG, Ma KL, Yan X, Chen NH*. DJ-1 regulating PI3K-Nrf2 signaling plays a significant role in bibenzyl compound 20C-mediated neuroprotection against rotenone-induced oxidative insult. Toxicology Letters, 2017; 271: 74-83. Xia CY, Chu SF, Zhang S, Gao Y, Ren Q, Lou YX, Luo P, Tian MT, Wang ZQ, Du GH, Tomioka Y, Yamakuni T, Zhang Y, Wang ZZ*, Chen NH*. Ginsenoside Rg1 alleviates corticosterone-induced dysfunction of gap junctions in astrocytes. Journal of Ethnopharmacology, 2017; 208: 207-213. (* co-corresponding author) Jin C, Wang ZZ, Zhou H, Lou YX, Chen J, Zuo W, Tian MT, Wang ZQ, Du GH, Kawahata I, Yamakuni T, Zhang Y, Chen NH*, Zhang DS*. Ginsenoside Rg1-induced antidepressant effects involve the protection of astrocyte gap junctions within the prefrontal cortex. Prog Neuropsychopharmacol Biol Psychiatry, 2017; 75: 183-191. Xia CY, Wang ZZ, Zhang Z, Chen J, Wang YY, Lou YX, Gao Y, Luo P, Ren Q, Du GH, Chen NH*. Corticosterone impairs gap junctions in the prefrontal cortical and hippocampal astrocytes via different mechanisms. Neuropharmacology, 2017; 131: 20-30. Chu SF, Zhang Z, Zhou X, He WB, Chen C, Luo P, Liu DD, Ai QD, Gong HF, Wang ZZ, Sun HS, Feng ZP, Chen NH*. Ginsenoside Rg1 protects against ischemic/reperfusion-induced neuronal injury through miR-144/Nrf2/ARE pathway. Acta Pharmacol Sin, 2018; online (doi: 10.1038/s41401-018-0154-z). Yang PF#, Wang ZZ#, Zhang Z, Liu DD, Manolios EN, Chen C, Yan X, Zuo W, Chen NH*, The extended application of The Rat Brain in Stereotaxic Coordinates in rats of various body weight. Journal of Neuroscience Methods, 2018; 307: 60-69. ( # co-first author) Xia CY, Wang ZZ, Tomioka Y, Chen NH*. A novel mechanism of depression: role for connexins. European Neuropsychopharmacology, 2018; 28(4): 483-498. Lou YX, Li J, Wang ZZ, Xia CY, Chen NH*. Glucocorticoid receptor activation induces decrease of hippocampal astrocyte number in rats. Psychopharmacology (Berl), 2018; 235(9): 2529-2540.

学术兼职

北京药理学会神经精神药理专业委员会副秘书长、北京药理学会神经精神药理专业委员会青年工作委员会副主任委员、中国药理学会补益药药理专业委员会委员、北京神经科学学会青年专业委员会委员、国家自然科学基金通信评审专家、北京市自然科学基金评审专家库成员和Experimental Neurology、Journal of Ethnopharmacology等SCI期刊审稿人

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