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个人简介

教育背景 1998/9 – 2002/7 沈阳药科大学 药物化学 学士 2002/9 – 2005/7 沈阳药科大学 药物化学 硕士 2015/9 – 2018/7 北京协和医学院 药物化学 博士 工作经历 2005/8-至今 中国医学科学院药物研究所 历任助理研究员,副研究

研究领域

抗肿瘤药物分子的设计、合成及活性研究 抗糖尿病药物分子的设计、合成及活性研究 靶向钾离子通道阻断剂的设计、合成及生物功能研究

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Jie Zhou, Ming Ji, Haiping Yao, Ran Cao, Hailong Zhao, Xiaoyu Wang, Xiaoguang Chen, Bailing Xu. Discovery of quinazoline-2,4(1H,3H)-dione derivatives as novel PARP-1/2 inhibitors: design, synthesis and their antitumor activity, Organic & Biomolecular Chemistry, 2018, 16, 3189-3220 2. Jie Zhou, Ming Ji, Zhixiang Zhu, Ran Cao, Xiaoguang Chen, Bailing Xu, Discovery of 2-substituted 1H-benzo[d]immidazole-4-carboxamide derivatives as novel poly(ADP-ribose) polymerase-1 inhibitors with in vivo anti-tumor activity, European Journal of Medicinal Chemistry, 2017, 132, 26-41. 3. 周洁,朱枝祥,季鸣,曹冉,陈晓光,徐柏玲,3-氨基苯甲酰胺衍生物PARP-1抑制剂的设计、合成及活性评价,中国药物化学杂志,2016, 26, 165-174. 4. Jie Zhou, Mingyu Ba, Bo Wang, Haibo Zhou, Jianbo Bie, Decai Fu, Yingli Cao, Bailing Xu, Ying Guo. Synthesis and biological evaluation of novel quinoxalinone-based HIV-1 reverse transcriptase inhibitors. MedChemComm, 2014, 5, 441-444. 5. Jie Zhou, Jing Jin, Yi Zhang, Yuwen, Yin, Xiaoguang Chen, Bailing Xu. Synthesis and antiproliferative evaluation of novel benzoimidazole-contained oxazole-bridged analogs of combretastatin A-4. European Journal of Medicinal Chemistry, 2013, 68, 222-232. 6. 周 洁, 朱枝祥, 陈晓光, 徐柏玲. 氮杂吲哚类PARP-1抑制剂的合成及活性评价,药学学报,2013, 48, 1792-1799. 7. Jie Zhou, Yi Zhang, Yiwen Cui, Zhanmei Li, Hongrui Song, Jinhua Dong, Xiaoguang Chen, Bailing Xu. Synthesis and cytotoxic evaluation of N-(4-methoxy-1H benzo[d]imidazol-7-yl) -arylsulfonamide and N-aryl-(4-methoxy-1H-benzo[d] imidazol)- 7-sulfonamide analogs of combretastatin A-4. Journal of Asian Natural Products Research, 2011, 3, 330-340. 8. Hailong Zhao, Ming Ji, Guonan Cui, Jie Zhou, Fangfang Lai, Xiaoguang Chen, Bailing Xu, Discovery of novel quinazoline-2,4(1H,3H)-dione derivatives as potent PARP-2 selective inhibitors, Bioorganic & Medicinal Chemistry. 2017, 25 , 4045-4054. 9. Qin Zhou, Ming Ji, Jie zhou, Jing Jin, Nina Xue, Ju Chen, Bailing xu, Xiaoguang chen , Poly (ADP-ribose) polymerases inhibitor, Zj6413, as a potential therapeuticagent against breast cancer, Biochemical Pharmacology, 2016, 107, 29-40. 10. Hai-Long Zhao, Hua-Long Chen, Jie zhou, Bailing xu, Structure identification of 4-amino -2-(arylamino)thiazole-5-carboxylic esters, Chinese Chemical Letters, 2016, 27, 302-304. 11. Haiping Yao, Ming Ji, Zhixiang Zhu, Jie Zhou, Ran Cao, Xiaoguang Chen, Bailing Xu. Discovery of 1-substituted benzyl-quinazoline-2,4(1H,3H)-dione derivatives as novel poly (ADP-ribose) polymerase-1 inhibitors. Bioorganic & Medicinal Chemistry. 2015, 23, 681–693. 12. Jianbo Bie, Shuainan Liu, Jie Zhou, Bailing Xu, Zhufang Shen, Design, synthesis and biological evaluation of 7-nitro-1H-indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase. Bioorgnic Medicinal Chemistry, 2014, 22, 1850-1862. 13. Chang Liu, Jing Jin, Liang Chen, Jie Zhou, Xiaoguang Chen, Decai, Fu, Hongrui Song, Bailing Xu. Synthesis and biological evaluation of novel human Pin1 inhibitors with benzophenone skeleton. Bioorgnic Medicinal Chemistry, 2012, 20, 2992-2999. 14. Liang Chen, Zhanmei Li, Jie Zhou, Hongrui Song, Bailing Xu. Facile and efficient synthesis of 5,7-disubstituted thiazolo[5,4-d]pyrimidine-4,6(5H,7H)-diones. Chinese Chemical Letters, 2012, 23, 695-698.

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