个人简介
教育背景
2009/9–2012/7,北京协和医学院,药物化学,博士
2006/9–2009/7,南昌大学医学院,药物化学,硕士
2002/9–2006/7,安徽工业大学,应用化学,学士
工作经历
2016/10-至今,中国医学科学院药物研究所,合成药物化学室,副研究员
2012/8-2016/9,中国医学科学院药物研究所,合成药物化学室,助理研究员
研究领域
主要研究方向包括代谢性疾病及耐药结核病的创新药物研究,金属催化的芳杂环合成方法学研究。
1. 抗糖尿病药物分子设计、合成及活性研究
2. 抗结核药物分子设计、合成及活性研究
3. 创新药物开发及合成工艺研究
4. 基于金属催化的芳杂环有机合成方法学研究
近期论文
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1. Li Peng, Wang Bin, Zhang Xinwei, Sarah M. Batt, Gurdyal S. Besra, Zhang Tingting, Ma Chen, Zhang Dongfeng, Lin Ziyun, Li Gang*, Huang Haihong*, Lu Yu*. Identification of novel benzothiopyranone compounds against Mycobacterium tuberculosis through scaffold morphing from benzothiazinones[J]. Eur. J. Med. Chem., 2018, 160: 157-170.
2. Li Peng, Wu Yongqi, Zhang Tingting, Ma Chen, Lin Ziyun, Li Gang*, Huang Haihong*. An efficient and concise access to 2-amino-4H-benzothiopyran-4-one derivatives[J]. Beilstein J. Org. Chem., 2019, 15, 703-709.
3. Wang Pengxu, Wang Yanan, Lin Ziyun, Li Gang*, Huang Haihong*. A facile and efficient synthesis of quinazoline-2, 4(1H, 3H)-diones via sequential hydrogenation condensation[J]. Synth. Commun., 2018, 48(10): 1183-1189.
4. Li Gang#, Huan Yi#, Yuan Baokun, Wang Jin, Jiang Qian, Lin Ziyun, Shen Zhufang*, Huang Haihong*. Discovery of novel xanthine compounds targeting DPP-IV and GPR119 as anti-diabetic agents[J]. Eur. J. Med. Chem., 2016, 124: 103-116.
5. Li Gang, Li Li, Huang Haihong*, Yin Dali*. Ti (IV)-catalyzed cascade synthesis of tetrahydrofuro[3,2-d]oxazole from arene-1,4-diones[J]. Org. Biomol. Chem., 2015, 13(15): 4418-4421.
6. Li Gang#, Yuan Baokun#, Tang Wu, Zhao Hongyi, Lin Ziyun, Huang Haihong*. An improved efficient synthesis of the antibacterial agent torezolid[J]. Chem. Pharm. Bull., 2015, 63(2): 143-146.
7. Li Gang, Wang Jin, Yuan Baokun, Zhang Dongfeng, Lin Ziyun, Li Peng, Huang Haihong*. Iron-catalyzed one-pot synthesis of benzimidazoles from 2-nitroanilines and benzylic alcohols[J]. Tetrahedron Lett., 2013, 54(50): 6934-6936.
8. Li Gang, Xiao Qiong, Li Chun, Wang Xiaojian*, Yin, Dali. A facile preparation of tetralins from arene-1,4-diones using titanium(IV) chloride and triethylsilane[J]. Tetrahedron Lett., 2011, 52(50): 6827-6830.