个人简介
教育背景
2001.9 – 2005.7 沈阳药科大学,中药学,学士
2005.9 – 2010.7 北京协和医学院,药物化学,博士
工作经历
2010.8 – 2016.9 中国医学科学院&北京协和医学院药物研究所,助理研究员
2016.10 – 至今 中国医学科学院&北京协和医学院药物研究所,副研究员
研究领域
研究方向为微生物活性天然产物的发现,天然药物的生物合成及生物催化。
1. 微生物活性天然产物的发现:从特殊生境微生物、食药用真菌等中发现新颖结构活性天然产物,为新药研制提供先导化合物
2. 活性天然产物的生物合成和生物催化:解析结构独特的活性天然产物的生物合成途径,从中发现关键酶,通过异源表达对天然/非天然底物进行生物催化,且通过合成生物学技术提高活性化合物的产量
近期论文
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1. Zhen Xin †, Gong Ting † (co-first author), Wen Yan-Hua, Yan Dao-Jiang, Chen Jing-Jing and Zhu Ping *. Chrysoxanthones A–C, Three New Xanthone–Chromanone Heterdimers from Sponge-Associated Penicillium chrysogenum HLS111 Treated with Histone Deacetylase Inhibitor. Marine Drugs, 2018, 16, 357. (IF=4.379)
2. Gong Ting, Zhen Xin, Li Xing-Lun, Chen Jing-Jing, Chen Tian-Jiao, Yang Jing-Ling, Ping Zhu *. Tetrocarcin Q, a New Spirotetronate with a Unique Glycosyl Group from a Marine-Derived Actinomycete Micromonospora carbonacea LS276. Marine Drugs, 2018, 16, 74. (IF=4.379)
3. Li Bing-Juan, Wang Hao, Gong Ting, Chen Jing-Jing, Chen Tian-Jiao, Yang Jin-Ling, Zhu Ping*. Improving 10-deacetylbaccatin III-10-β-Oacetyltransferase catalytic fitness for Taxol production. Nature Communications, 2017, 8: 15544.
4. Liu Wan-Cang, Gong Ting, Wang Qing-Hua, Liang Xiao, Chen Jing-Jing, Zhu Ping*. Scaling-up fermentation of Pichia pastoris to demonstration-scale using new methanol-feeding strategy and increased air pressure instead of pure oxygen supplement. Scientific Reports, 2016, 6: 18439.
5. Zhen Xin †, Gong Ting † (co-first author), Liu Fu, Zhang Pei-Cheng, Zhou Wan-Qin, Li Yan, Zhu Ping*. A new analogue of echinomycin and a new cyclic dipeptide from a marine-derived Streptomyces sp. LS298. Marine Drugs, 2015, 13(11): 6947-6961.
6. Gong Ting, Zhen Xin, Li Bing-Juan, Yang Jin-Ling, Zhu Ping*. Two new monoterpenoid α-pyrones from a fungus Nectria sp. HLS206 associated with the marine sponge Gelliodes carnosa. J Asian Nat Prod Res., 2015, 17(6): 633-637.
7. Gong Ting, Zheng Li, Zhen Xin, He Hui-Xia, Zhu Hui-Xin, Zhu Ping*. Microbial transformation of oleanolic acid by Trichothecium roseum. J Asian Nat Prod Res., 2014, 16(4): 383-386.
8. Gong Ting, Zhang Ting, Wang Dong-Xiao, Chen Ruo-Yun*, Liu Ping, Yu De-Quan. Two new isoflavone glycosides from the vine stem of Millettia dielsiana. J Asian Nat Prod Res., 2014 , 16 (2) :181.
9. Gong Ting , Wang Dong-Xiao, Yang Yan, Liu Ping , Chen Ruo-Yun* , Yu De-Quan . A novel 3-arylcoumarin and three new 2-arylbenzofurans from Mucuna birdwoodiana. Chemical & Pharmaceutical Bulletin, 2010 , 41 (29) :254-256.
10. Gong Ting, Wang Dong-Xiao, Chen Ruo-Yun, Liu Ping, Yu De-Quan. Novel benzil and isoflavone derivatives from Millettia dielsiana. Planta Medica, 2009 , 75 (3) :236-242.