孔令雷 - 中国医学科学院药物研究所 -

个人简介

教育背景 2006.9-2009.7 军事医学科学院，获硕士学位 2009.9-2012.7 北京协和医学院，获医学博士学位 2012.8-2015.7 军事医学科学院，博士后工作经历 2015.8-2016.8 中国医学科学院药物研究所国家药物筛选中心，助理研究员 2016.9-至今中国医学科学院药物研究所国家药物筛选中心，副研究员

研究领域

主要从事神经药理学及新药发现方面的工作。研究内容包括：脑缺血及溶栓后出血转化发生的分子机制和药物干预研究；脑缺血相关药物靶点确证及先导化合物的筛选、评价。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

(1) Kong LL, Shen GL, Wang ZY, Zhuang XM, Xiao WB, Yuan M, Gong ZH, Li H. Inhibition of P-Glycoprotein and Multidrug Resistance-Associated Protein 2 Regulates the Hepatobiliary Excretion and Plasma Exposure of Thienorphine and Its Glucuronide Conjugate. Front Pharmacol. 2016,7:242. (2) Kong LL, Wang ZY, Hu JF, Yuan YH, Li H, Chen NH. Inhibition of chemokine-like factor 1 improves blood-brain barrier dysfunction in rats following focal cerebral ischemia. Neurosci Lett. 2016,627:192-198. (3) Kong LL, Zhuang XM, Yang HY, Yuan M, Xu L, Li H. Inhibition of P-glycoprotein Gene Expression and Function Enhances Triptolide-induced Hepatotoxicity in Mice. Sci Rep. 2015,5:11747. (4) Kong LL, Wang ZY, Han N, Zhuang XM, Wang ZZ, Li H, Chen NH. Neutralization of chemokine-like factor 1, a novel C-C chemokine, protects against focal cerebral ischemia by inhibiting neutrophil infiltration via MAPK pathways in rats. J Neuroinflammation. 2014,11:112. (5) Kong LL, Wang ZY, Hu JF, Yuan YH, Han N, Li H*, Chen NH. Inhibition of chemokine-like factor 1 protects against focal cerebral ischemia through the promotion of energy metabolism and anti-apoptotic effect. Neurochem Int. 2014,76:91-98. (6) Kong LL, Hu JF, Zhang W, Yuan YH, Han N, Chen NH. C19, a C-terminal peptide of chemokine-like factor 1, protects the brain against focal brain ischemia in rats. Neurosci Lett. 2012,508(1):13-16. (7) Kong LL, Hu JF, Zhang W, Yuan YH, Ma KL, Han N, Chen NH. Expression of chemokine-like factor 1 after focal cerebral ischemia in the rat. Neurosci Lett. 2011,505(1):14-18. (8) Yan LD#, Kong LL#, Yong Z, Dong HJ, Chi MG, Pan XF, Zhang C, Liang YJ, Gong ZH, Liu KL. Inhibition of endothelin-1 and hypoxia-induced pulmonary pressor responses in the rat by a novel selective endothelin-A receptor antagonist, di-n-butylaminocarbamyl-L-leucyl-D-tryptophanyl-D-4-chloro-Phe. J Cardiovasc Pharmacol. 2010,56(3):246-254.

学术兼职

中国中药协会脑病专业委员会委员，北京市药理学会神经精神药理专业委员会委员，青年委员会委员