个人简介
教育背景
2010.9-2013.7 北京大学药学院化学生物学系，获得博士学位
2008.9-2010.7 北京大学药学院化学生物学系，获得硕士学位
2004.9-2008.7 北京大学药学院，获学士学位
工作经历
2013.9-2017.9 中国医学科学院药物研究所，新药开发室，助理研究员
2017.10-至今 中国医学科学院药物研究所，新药开发室，副研究员
研究领域
1. 靶向肿瘤干细胞的小分子化合物的发现和结构优化研究
2. 调节Wnt/porcupine信号通路的小分子化合物的发现和结构优化研究
3. 针对耐药菌的小分子化合物的发现和结构优化研究
4. 活性天然产物的全合成和结构优化研究
5. 新合成方法学、新合成技术的研究和应用研究
近期论文
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1. Wenxuan Zhang, Wenjie Xue, Yuqing Jia, Gang Wen, Xu Lian, Jing Shen, Ailin Liu and Song Wu*, A Concise Synthesis of (±)-7-O-Galloyltricetiflavan, RSC Adv., 2018, 8, 14389.
2. Wenxuan Zhang,#* Jun Wu,# Bo Li, Xu Lian, Jie Xia, Qi Zhou, Song Wu*, Design and synthesis of conformationally constrained salinomycin derivatives, Eur. J. Med. Chem., 2017, 138, 353.
3. Gang Wen, Wenxuan Zhang* and Song Wu *, A Novel Synthesis of 4-Acetoxyl 5(4H)-Oxazolones by Direct α-Oxidation of N-Benzoyl Amino-Acid Using Hypervalent Iodine, Molecules 2017, 22, 1102.
4. Bo Li#, Jun Wu#, Wenxuan Zhang*, Zhongwen Li, Gang Chen, Qi Zhou, Song Wu*, Synthesis and biological activity of salinomycin-hydroxamic acid conjugates, Bioorg Med Chem Lett, 2017, 27, 1624.
5. Wenxuan Zhang, Jun Wu, Bo Li, Jie Xia, Hongna Wu, Liu Wang, Jie Hao, Qi Zhou, Song Wu*, Synthesis and biological activity evaluation of 20-epi-salinomycin and its 20-O-acyl derivatives, RSC Adv., 2016, 6, 41885.
6. Wenxuan Zhang#, Jun Wu#, Bo Li, Hongna Wu, Liu Wang, Jie Hao, Song Wu*, Qi Zhou*, Structure–activity & structure–toxicity relationship study of salinomycin diastereoisomers and their benzoylated derivatives, Organic & Biomolecular Chemistry, 2016, 14, 2840. (inside cover)
7. Wenxuan Zhang#, Jiming Wang#, Xihuan Luo, Xiangbao Meng*, Zhongjun Li*，An attempt to construct the C/D ring system of parkacine by intramolecular cycloaddition of azomethine ylide and alkyne, Tetrahedron Lett., 2016, 57, 1981.
8. Wenxuan Zhang, Hong-Na Wu, Bo Li, Hong-Lin Wu, Dong-Mei Wang, Song Wu*, The Synthesis of the Metabolites of 2′,3′,5′-Tri-O-acetyl-N6-(3-hydroxyphenyl) Adenosine (WS070117). Molecules, 2015, 21, 8.
9. Wenxuan Zhang, Ying Chen, Qingzhao Liang, Hui Li, Hongwei Jin, Liangren Zhang, Xiangbao Meng*, and Zhongjun Li*, Design, Synthesis and Antibacterial Activities of Conformationally Constrained Kanamycin A Derivatives. The Journal of Organic Chemistry, 2013, 78, 400−409.
10. Wenxuan Zhang, Qingzhao Liang, Hui Li, Xiangbao Meng* and Zhongjun Li*, Concise synthesis and antitumor activity of Bengamide E and its analogs, Tetrahedron, 2013, 69, 664-672.
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