个人简介

B.A., 1972, State University of New York at Potsdam Ph.D., 1977, University of New Hampshire Postdoctoral Fellow, 1977-79, Colorado State University

研究领域

Organic Chemistry

The principal emphasis of Professor Comins’ research program is the development of new synthetic methodologies and strategies for the asymmetric synthesis of alkaloids, natural products and biologically active compounds. He is particularly interested in the design of new synthetic reactions, especially practical, high-yield methods for the synthesis of complex organic molecules with specific stereochemistry. Several strategies based on heterocyclic and organometallic chemistry are under investigation. The Comins group develops methodology useful for the synthesis of compounds having a broad range of biological properties, i.e. neuroleptic, antihypertensive, anti-inflammatory, antitumor, and anticonvulsant activities. Other studies include basic research on the development of synthetic methods for the synthesis of optically active compounds using novel heterocycles as chiral building blocks. The Comins group has accomplished the synthesis of over 40 alkaloids. Synthetic achievements include asymmetric syntheses of (+)-elaeokanine A, (+)-elaeokanine C, (-)-septicine, (-)-tylophorine, (-)-laudanosine, (+)-carnegine, (+)-glaucine, (-)-xylopinine, (-)-pumiliotoxin C, (-)-lasubine I, (+)-subcosine I, (-)-sedamine, (+)-camptothecin, (+)-10-hydroxycamptothecin, (-)-porantheridine, (-)-indolizidine 235B, (-)-indolizidine 205A, (+)-indolizidine 209D, (-)-indolizidine 207A, trans-decahydroquinoline alkaloid (+)-219A, piperidine alkaloid (+)-241D, (+)-dienomycin C, (+)-benzomorphan, (+)-metazocine, (-)-Nα-acetyl-Nβ-methylphlegmarine, (-)-perhydrohistrionicotoxin, (+)-luciduline, (+)-cannabisativine, (+)-streptazolin, (+)-desoxoprosopinine, (+)-deoxynojirimycin, (+)-allopumiliotoxin 267A, (-)-Nα-methyl-Nβ-acetylphlegmarine, (-)-phlegmarine, (-)-Nα-methylphlegmarine, (-)-Nβ-methyl-phlegmarine, (+)-lennoxamine, (+)-hyperaspine. (-)-brevicolline, (-)-macrostomine, alkaloid (-)-205B, and (-)-cermizine D.

近期论文

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Francis G. Fang, Edward M. Huie, Shiping Xie, and Daniel L. Comins, "Preparation of Camptothecin Derivative by Intramolecular Cyclisation," U.S. Patent No. 6,063,923 (2000). Frances G. Fang, Edward M. Huie, Shiping Xie, and Daniel L. Comins, "Preparation of a Camptothecin Derivative by Intramolecular Cyclization," U.S. Patent No. 6,462,196 (2002). Daniel L. Comins and Shenlin Huang, "A Short Synthesis of Pyridine-Based Pharmaceutical Intermediates," U.S. Patent No. 6,534,656 (2003). Frances G. Fang, Edward M. Huie, Shiping Xie, and Daniel L. Comins, "Preparation of a Camptothecin Derivative by Intramolecular Cyclization," U.S. Patent No. 6,559,309 (2003). Daniel L. Comins and Shenlin Huang, "Short Synthesis of Pyridine-Based Pharmaceutical Intermediates," U.S. Patent No.: 6,706,884 (2004). Daniel L. Comins and Shenlin Huang, "Short Synthesis of Pyridine-Based Pharmaceutical Intermediates," U.S. Patent No. 6,855,825 (2005). Daniel L. Comins and Shenlin Huang, "Short Synthesis of Pyridine-Based Pharmaceutical Intermediates," U.S. Patent No. 6,987,189 (2006). Daniel L. Comins and Emilie Despagnet, "Synthesis of Nicotine Derivatives from Nicotine," U.S. Patent No. 6,995,265 (2006). Comins, Daniel L., Florence C. Février, and Emilie Despagnet, "Regioselective Halogenation of Nicotine and Substituted Nicotines," U.S. Patent No.: 7,067,672 (2006). Laura S. King, Emilie Despagnet and Daniel L. Comins, "Regiospecific Synthesis of Nicotine Derivatives," U.S. Patent No.: 7,112,678 (2006). Daniel L. Comins and Emilie D. Smith, "Synthesis of Nicotine Derivatives from Nicotine," U.S. Patent No.: 7,132,545 (2006). Daniel L. Comins, Florence Février, and Emilie Despagnet Smith, "Regioselective Halogenation of Nicotine and Substituted Nicotines," U.S. Patent No.: 7,179,917 (2007). Laura S. King, Emilie Smith, and Daniel L. Comins, "Regiospecific Synthesis of Nicotine Derivatives," U.S. Patent No.: 7,304,160 (2007). Daniel L. Comins and Emilie D. Smith, "Synthesis of Nicotine Derivatives from Nicotine," U.S. Patent No. 7,361,768 (2008). Daniel L. Comins, Florence C. Février, and Emilie D. Smith, "Regioselective Halogenation of Nicotine and Substituted Nicotines," U.S. Patent No. 7,501,520 (2009). Daniel L. Comins and Emilie D. Smith, "Synthesis of Nicotine Derivatives from Nicotine," U.S. Patent No. 7,553,968 (2009). Laura S. King, Emilie D. Smith, and Daniel L. Comins, "Regiospecific Synthesis of Nicotine Derivatives," U.S. Patent No. 7,671,209 (2010). Daniel L. Comins, Florence C. Février, and Pauline Ondachi, "Synthesis and Regioselective Substitution of 6-Halo- and 6-Alkoxy Nicotine Derivatives," U.S. Patent No. 7,820,826 (2010). Laura S. King, Emilie D. Smith, and Daniel L. Comins, "Regiospecific Synthesis of Nicotine Derivatives," U.S. Patent No. 7,875,724 (2011). Daniel L. Comins and Emilie D. Smith, "Synthesis of Nicotine Derivatives from Nicotine," U.S. Patent No. 7,888,512 (2011).