Soh, H. Tom - Stanford University - Department of Electrical Engineering

个人简介

EDUCATION June 1999 Ph.D. Stanford University, Stanford, CA Electrical Engineering June 1995 M.S. Stanford University, Stanford, CA Electrical Engineering May 1993 M.Eng. Cornell University, Ithaca, NY Electrical Engineering May 1992 B.S. Cornell University, Ithaca, NY Double Major with Distinction in Mechanical Engr. & Materials Science EMPLOYMENT 1/16 - Present Professor, Department of Chemical Engineering, by courtesy Stanford University, Stanford, CA 7/15–Present Professor, Department of Electrical Engineering and Radiology Stanford University, Stanford, CA 10/11–6/15 Associate Director, California NanoSystems Institute (CNSI),University of California, Santa Barbara 7/11–6/15 Professor, Department of Mechanical Engineering & Department of Materials,University of California, Santa Barbara 3/11–6/15 Ruth Garland Endowed Chair at the University of California, Santa Barbara 5/08–6/15 Co-Director, Center for Stem Cell Biology and Engineering,University of California, Santa Barbara 7/11–7/13 (By Courtesy), Department of Molecular & Medical Pharmacology,David Geffen School of Medicine, University of California, Los Angeles 7/07–7/11 Associate Professor, Departments of Mechanical Engineering & Materials,University of California, Santa Barbara 4/03–6/07 Assistant Professor, Departments of Mechanical Engineering & Materials,University of California, Santa Barbara 8/00–4/03 Technical Manager, MEMS Device Research Group Bell Laboratories, Lucent Technologies, Murray Hill, NJ and Agere Systems R&D group, Agere Systems, Allentown, PA 12/99–7/00 Member of Technical Staff, MEMS Research group,Physical Sciences Division, Bell Laboratories, Lucent Technologies, Murray Hill, NJ 6/99 - 12/99 Research Associate, Prof. C.F. Quate Laboratory Department of Electrical Engineering, Stanford University, Stanford CA

研究领域

In vitro directed evolution of functional molecules Biosensors and integrated molecular diagnostics Bio-separations and cell sorting technologies usingmicrofluidics

近期论文

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I. A. P. Thompson, L. Zheng, M. Eisenstein, H. T. Soh. “Rational Design of Aptamer Switches with Programmable pH Response.” Nature Communications, 11, 2946 (2020) H. Qu, Q. Ma, L. Wang, Y. Mao, M. Eisenstein, H. T. Soh*, L. Zheng*. “Measuring aptamer folding energy using a molecular clamp.” Journal of the American Chemical Society 142, 27, 11743-11749 (2020) B. D. Wilson, H. T. Soh. “Re-evaluating the conventional wisdom about binding assays.” Trends in Biochemical Sciences(2020) D. Chan, J. Chien, E. Axpe, L. Blankemeier, S. W. Baker, S. Swaminathan, V. A. Piunova, D. Y. Zubarev, H. T. Soh, E. A. Appel. "Combinatorial Polyacrylamide Hydrogels for Preventing Biofouling on Implantable Biosensors." Submitted(2020) D. Wu, T. Feagin, P. Mage, A. Rangel, L. Wan, A. Li, J. Coller, M. Eisenstein, S. Pitteri, H. T. Soh. "Automated platform for high-throughput screening of base-modified aptamers for affinity and specificity." Submitted(2020) M. Poudineh, C. L. Maikawa, E. Y. Ma, J. Pan, D. Mamerow, Y. Han, S. W. Baker, A. Beirami, M. Eisenstein, S. Kim, J.Vuckovic, E. A. Appel, H. T. Soh. “Continuous detection of glucose and insulin in live animals.” Submitted (2020) J. Chien, S. W. Baker, H. T. Soh, A. Arabian. "Design and Analysis of a Sample-and-Hold CMOS Electrochemical Sensor for Aptamer-based Therapeutic Drug Monitoring." Submitted (2020) A. Rangel, A. Hariri, M. Eisenstein, H. T. Soh. "Stimulus-responsive materials based on aptamer switches."Submitted (2020) J. Wang, R. Ahmed, Y. Zeng, K. Fu, H. T. Soh, U. Demirci. “Nano-topographically engineered multifunctional immunocyte-templated micromotors.” Submitted (2019) H. Lee, S. Alizadeh, T. J. Kim, S. Park, H. T. Soh, A. Mani, S. J. Kim. “Overlimiting current in non-uniform arraysof microchannels.” arXiv (2019) B. Kang, S. V. Park, H. T. Soh, S. S. Oh. “A Dual-sensing DNA Nanostructure with an Ultra-broad Detection Range.”ACS Sensors 4 (10) 2802-2808 (2019) B. Wilson, A. Hariri, I. Thompson, M. Eisenstein, H. T. Soh. "Independent Control of the Thermodynamic and Kinetic Properties of Aptamer Switches." Nature Communications 10, 5079 (2019) P.L. Mage, A.T. Csordas, T. Brown, D. Klinger, M. Eise, S. Mitragotri, C.Hawker and H. T. Soh. "Shape-based Separation of Synthetic Microparticles.” Nature Materials 18, 82-89 (2019) C. K. L. Gordon*, D. Wu*, A. Pusuluri, T. Feagin, A. T. Csordas, M. Eisenstein, C. J. Hawker, J. Niu, H. T. Soh. “ClickParticle Display for Base-Modified Aptamer Discovery.” ACS Chemical Biology 14 (12), 2652-2662(2019) B. Wilson, M. Eisenstein, H. T. Soh. “High-Fidelity Nanopore Sequencing of Ultra-Short DNA Targets.” Analytical Chemistry 91 (10) 6783-6789 (2019) Barnes, L. V, D.M. Heithoff, S.P. Mahan, G.N. Fox, A. Zambrano, J. Choe, L.N. Fitzgibbons, J.D. Marth, J.C. Fried,H. T. Soh*, M.J. Mahan*. “Smartphone-based pathogen diagnosis in urinary sepsis patients.” EbioMedicine 36 73-82 (2018) T. Feagin, N. Maganzini, H. T. Soh “Strategies for Creating Structure-Switching Aptamers.” ACS Sensors 3 (9) 1611-1615 (2018) C.K. L. Gordon, M. Eisenstein, H. T. Soh “Direct Selection Strategy for Isolating Aptamers with pH-Sensitive Binding Activity.” ACS Sensors 3 (12) 2574-2580 (2018) M. Gotrik, G. Sekhon, S. Saurabh, M. Nakamoto, M. Eisenstein, H. T. Soh. “Direct Selection ofFluorescenceEnhancing RNA Aptamers.” Journal of the American Chemical Society 140 (10) 3583-3591 (2018) A. Pusuluri, V. Krishnan, V. Lensch, A. Sarode, E. Bunyan, D. Vogus, S. Menegatti, H. T. Soh*, S. Mitragotri*.“Treating Tumors at Low Drug Doses Using an Aptamer-Peptide Synergistic Drug Conjugate.” Angewandte Chemie International Edition 58 (5) 1437-1441 (2018) J. McGivney, A. Csordas, F. Walker, E. Bagley, E.Gruber, P. Mage, J. Casas-Finet, M. Nakamoto, M. Eisenstein, C.Larkin, R. Strouse, H. T. Soh. "A Strategy for Generating Sequence-Defined Aptamer Reagent Sets for Detecting Protein Contaminants in Biotherapeutics.” Analytical Chemistry 90 (5) 3262-3269 (2018) P.L. Mage, B.S. Ferguson, D. Maliniak, K.L Ploense, T.E. Kippin, and H.T. Soh “Closed-loop Control of Circulating Drug Levels in Live Animals.” Nature Biomedical Engineering 114 (4) 645-650 (2017) J. Niu, D. J. Lunn, A.Pusuluri, J.I. Yoo, M.A. O’Malley, S. Mitragotri, H. T. Soh*, C. J. Hawker* “Engineering live cell surfaces with functional polymers via cytocompatible controlled radical polymerization.” Nature Chemistry 9,537–545 (2017)