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研究领域

主要研究方向为生物药用高分子材料的基础理论研究及其在生物医学和生物技术领域的应用,包括药物控制释放、疾病诊断、基因治疗等;药物合成研究。

近期论文

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1. Wenjin Xu, Imtiaz Siddiqui, Minakshi Nihal, Srikanth Pilla, KimberlyRosenthal,HasanMukhtar, and Shaoqin Gong. Aptamer-conjugated and doxorubicin-loaded unimolecular micelles for targeted therapy of prostate cancer. Biomaterials, 2013, 34, 5244-5253. 2. Wenjin Xu, Jocelyn F. Burke, Srikanth Pilla, Herbert Chen, Renata Jaskula-Sztul, and Shaoqin Gong. Octreotide-functionalized and Resveratrol-loaded unimolecular micelle for targeted medullary thyroid cancer therapy.Nanoscale, 2013, 5, 9924-33. 3. Wenjin Xu, Xianran He, Min Zhong, Xianming Hu, Yuling Xiao*. A novel pH-responsive hydrogel based on natural polysaccharides for controlled release of protein drugs. RSC Adv., 2015, 5 (5), 3157 – 3167. 4. Wenjin Xu, Gifty Osei-Prempeh, Carolina Lema, E. Davis Oldham, Renato J. Aguilera, Sean Parkin, Stephen E. Rankin, Barbara L. Knutson, Hans-Joachim Lehmler. Synthesis, thermal properties, and cytotoxicity evaluation of hydrocarbon and fluorocarbon alkyl β-D-xylopyranoside surfactants. Carbohydrate Research, 2012, 349, 12-23. 5. Wenjin Xu, Hao Guo, Qifeng Zhu, Xianbing Ke, Xianming Hu. Asymmetric Borane Reduction of ProchiralKetones Catalyzed by α,α-Disubstituted Aziridine- methanols. Catalysis Letters, 2008,125, 302-307. 6.Wenjin Xu, Hao Guo, Jun Zhang, Qifeng Zhu, Xianming Hu. Asymmetric reduction of acetophenone using α,α-disubstitutedaziridinemethanols and borane. Journal of Molecular Catalysis A: Chemical, 2009, 300, 25-28. 7. Wenjin Xu, Jun Zhang, Hao Guo, Qifeng Zhu and Xianming Hu. The influence of substituents on the hydroxyl-bearing carbon in the aza-Payne rearrangement of aziridinemethanols. Letters in Organic Chemistry, 2009, 6, 412-415. 8. Alireza Javadi, Yuling Xiao, Wenjin Xu and Shaoqin Gong. Chemically modified graphene/P (VDF-TrFE-CFE) electroactive polymer nanocomposites with superior electromechanical performance. J. Mater. Chem., 2012, 22, 830-834. 9.Yuling Xiao, Hong Hao, Alireza Javadi, Jonathan W. Engle, Wenjin Xu, Yunan Yang, Yin Zhang, Todd E. Barnhart, Weibo Cai and Shaoqin Gong. Multifunctional unimolecular micelles for cancer-targeted drug delivery and positron emission tomography imaging. Biomaterials, 2012, 33, 3071-3082. 10. Yuling Xiao, Renata Jaskula-Sztul, Alireza Javadi, Wenjin Xu, Jacob Eide, Ajitha Dammalapati, Muthusamy Kunnimalaiyaan, Herbert Chen and Shaoqin Gong. Co-delivery of doxorubicin and siRNA using octreotide-conjugated gold nanorods for targeted neuroendocrine cancer therapy. Nanoscale, 2012, 4, 7185-7193. 11. Yuling Xiao, Hao Hong, Vyara Z. Matson, Alireza Javadi, Wenjin Xu, Yunan Yang, Yin Zhang, Jonathan W. Engle, Robert J. Nickles, Weibo Cai, Douglas A. Steeber, and Shaoqin Gong. Gold nanorods conjugated with doxorubicin and cRGD for combined anticancer drug delivery and PET imaging. Theranostics.2012, 2, 757-768. 12. Yuling Xiao, WenjinXu, Qifeng Zhu, Bingfang Yan, Jin Yang, Xianran He, Shucai Liang, Xianming Hu. Preparation and Characterization of a Novel Pachyman-Based Pharmaceutical aid II. A pH-Sensitive, Biodegradable and Biocompatible Hydrogel for Controlled Release of Protein Drugs. Carbohydrate Polymers, 2009, 77, 612-620. 13. Xianbing Ke, Hao Hu, Wenjin Xu, Qifeng Zhu, Xianming Hu. Significant steroids: effective and general synthesis of 4α- and 4β-amino-5α-androstanes. Chemical Communications, 2009, 9, 1037-1039. 14. Xianbing Ke, Hao Hu, Wenjin Xu, Qifeng Zhu, Xianming Hu. A facile and general synthesis of 2β-aminosteroids.Synthesis, 2009, 8, 1255-1260. 15. Zhigang Xiong, Qi Wei, Hanmei Chen, Wenjin Xu, Guofu Qiu, Shucai Liang, Xianming Hu. Microbial Transformation of Androst-4-ene-3,17-dione by Beauveria Bassiana. Steroids, 2006, 71, 979-983. 16. Qifeng Zhu, Yuanhu Pan, Zaixu Xu, Ruiming Li, Guofu Qiu, Wenjin Xu, Xianbing Ke, Lamei Wu, Xianming Hu. Synthesis and potential anticonvulsant activity of new N-3-substituted 5,5-cyclopropanespirohydantoins.European Journal of Medicinal Chemistry, 2009, 44, 296-302.

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