个人简介

Ph.D. Stanford University, 1979 NIH Postdoctoral Fellow, Columbia University, 1979-1982 National Research Service Award (National Cancer Institute, NIH); Searle Scholar

研究领域

Biological Chemistry

The Tullius Group introduced hydroxyl radical footprinting, which is widely used for the structural study of DNA, DNA-protein complexes, and RNA. They investigate the connection between structural properties of DNA and genomics, including evolutionary selection for DNA structure in the human genome. Their human genome studies were initiated with funding from the ENCODE (Encyclopedia of DNA Elements) Pilot Project, which was organized by the National Human Genome Research Institute of the NIH to discover functional elements in the human genome.

近期论文

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Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project E Birney, JA Stamatoyannopoulos, A Dutta, R Guigó, TR Gingeras, ... Nature 447 (7146), 799-816 3250 2007 Oxidative strand scission of nucleic acids: Routes initiated by hydrogen abstraction from the sugar moiety WK Pogozelski, TD Tullius Chemical reviews 98 (3), 1089-1108 900 1998 Hydroxyl radical" footprinting": high-resolution information about DNA-protein contacts and application to lambda repressor and Cro protein TD Tullius, BA Dombroski Proceedings of the National Academy of Sciences 83 (15), 5469 503 1986 DNA strand breaking by the hydroxyl radical is governed by the accessible surface areas of the hydrogen atoms of the DNA backbone B Balasubramanian, WK Pogozelski, TD Tullius Proceedings of the National Academy of Sciences 95 (17), 9738 340 1998 The unusual conformation adopted by the adenine tracts in kinetoplast DNA AM Burkhoff, TD Tullius Cell 48 (6), 935-943 317 1987 Iron (II) EDTA used to measure the helical twist along any DNA molecule TD Tullius, BA Dombroski Science 230 (4726), 679 314 1985 Hydroxyl radical footprinting: A high-resolution method for mapping protein-DNA contacts TD Tullius, BA Dombroski, MEA Churchill, L Kam Methods in enzymology 155, 537-558 290 1987 The structure of DNA in a nucleosome JJ Hayes, TD Tullius, AP Wolffe Proceedings of the National Academy of Sciences 87 (19), 7405 285 1990 Hydroxyl radical footprinting WJ Dixon, JJ Hayes, JR Levin, MF Weidner, BA Dombroski, TD Tullius Methods in enzymology 208, 380-413 211 1991 A Holliday recombination intermediate is twofold symmetric ME Churchill, TD Tullius, NR Kallenbach, NC Seeman Proceedings of the National Academy of Sciences 85 (13), 4653