研究领域
主要研究领域为疑难危重的自身免疫性肾脏病，包括ANCA相关小血管炎、抗GBM病、狼疮肾炎和血栓性微血管病。特色在于从临床工作中发现科学问题，利用我国临床资源优势，运用现代免疫学技术开展机制研究并最终用于临床。重点为自身抗体的抗原决定簇分析及其扩散机制、自身免疫肾脏病病因研究和补体异常活化在肾脏疾病发生发展中的作用。涉及分子免疫学、蛋白质生化、细胞生物学和分子信息学等。
近期论文
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1. Gou SJ, Yuan J, Chen M, Yu F, Zhao MH, Circulating complement activation profile of patients with ANCA-associated vasculitis. Kidney Int, In press, 2012.
2. Chen M, Gao Y, Guo XH, Zhao MH, Propylthiouracil-induced anti-neutrophil cytoplasmic antibody-associated vasculitis. Nat Rev Nephrol, 8(8): 476-83, 2012. (Review)
3. Cui Z, Zhao MH, Advances in human antiglomerular basement membrane disease. Nat Rev Nephrol, 7(12): 697-705, 2011. (Review)
4. Cui Z, Zhao MH, Segelmark M, Hellmark T, Natural autoantibodies to myeloperoxidase, proteinase 3 and the glomerular basement membrane are present in normal individuals. Kidney Int, 78(6): 590-7, 2010.
5. Yu F, Tan Y, Liu G, Wang XS, Zou WZ, Zhao MH, The clinicopathological characteristics and outcome of patients with crescentic lupus nephritis: A study from a single center. Kideny Int, 76: 307-317, 2009.
6. Zhao J, Cui Z*, Yang R, Jia XY, Zhang Y, Zhao MH, Anti-glomerular basement membrane autoantibodies against different target antigens are associated with disease severity. Kidney Int, 76(10): 1108-15, 2009.
7. Chen M, Kallenberg CGM, Zhao MH, Antineutrophil cytoplasmic autoantibodies-negative pauci-immune crescentic glomerulonephritis. Nat Rev Nephrol, 5(6): 313-318, 2009. (Review)
8. Yang R, Hellmark T, Zhao J, Cui Z, Segelmark M, Zhao MH, Wang HY, Antigen and epitope specificity of anti-glomerular basement membrane antibodies in patients with goodpasture disease with or without anti-neutrophil cytoplasmic antibodies. J Am Soc Nephrol, 18(4): 1338-43, 2007.
9. Chen M, Yu F, Wang SX, Zou WZ, Zhao MH, Wang HY, Antineutrophil cytoplasmic autoantibody negative pauci-immune crescentic glomerulonephritis. J Am Soc Nephrol, 18: 599-605, 2007.
10. Cui Z, Wang HY, Zhao MH. Natural autoantibodies against glomerular basement membrane exist in normal human sera. Kidney Int, 69:894-899, 2006.
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