个人简介

B.A., Occidental College, 1987 Ph.D., University of Illinois at Urbana-Champaign, 1992

研究领域

Biological Chemistry/Synthetic Organic Chemistry/Physical Chemistry

The Grinstaff Group pursues highly interdisciplinary research in the areas of biological and macromolecular chemistry. The major goal in these research projects is to elucidate the underlying fundamental chemistry and engineering principles and to use that insight to direct our creative and scientific efforts. We are designing, synthesizing, and characterizing novel dendrimers, termed “biodendrimers,” for tissue engineering and biotechnological applications. Currently, we are evaluating these novel biomaterials for the repair of corneal lacerations, for the delivery of anti-cancer drugs, for the delivery of DNA, and as temporary biodegradable scaffolds for cartilage repair. We are creating novel polymeric coatings termed “interfacial biomaterials” that control biology on plastic, metal, and ceramic surfaces. We are designing electrochemical-based sensors/devices using conducting polymer nanostructures and specific DNA structural motifs.

近期论文

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"An Ex vivo Model of Venous and Arterial Hemorrhage for Evaluation of Hemostatic Dressing Efficacy." Juan C. Villa-Camacho, Cynthia Ghobril, Lorenzo Añez-Bustillos, Mark W. Grinstaff, Edward K. Rodríguez, Ara Nazarian BMC Musculoskeletal Disorders, 2015, in press "Paclitaxel-Loaded Expansile Nanoparticles Enhance Chemotherapeutic Drug-delivery in Mesothelioma 3D Multicellular Spheroids." Hongyi Lei, Sophie C. Hofferberth, Rong Liu, Aaron Colby, Kristie M. Tevis, Mark W. Grinstaff, and Yolonda L. Colson Journal of Thoracic and Cardiovascular Surgery, 2015, in press "The Chemistry and Engineering of Polymeric Hydrogel Adhesives for Wound Closure: A Tutorial." Cynthia Ghobril and Mark W. Grinstaff Chemical Society Reviews, 2015, in press "The Self-Assembly of Anticancer Camptothecin-Dipeptide Nano-tubes: A Minimalistic and High Drug Loading Approach to Increased Efficacy." Se Hye Kim, Jonah A. Kaplan, Yuan Sun, Aileen Shieh, Hui-Lung Sun, Carlo M. Croce, Mark W. Grinstaff, and Jon R. Parquette Chemistry: A European Journal, 2015, 21, 101-105 doi:10.1002/chem.201404520 "Nanoparticle Therapy in Lung Cancer." Kimberly A. Zubris, Mark W. Grinstaff, and Yolonda L. Colson Adult Chest Surgery, Editors: Marsha S. Loeb and Karen W. Davis, The McGraw-Hill Companies, 2014, 171, 1346-1349 "The Effects of Counterion Composition on the Rheological and Conductive Properties of Mono- and Diphosphonium Ionic Liquids." Reimi Yonekura and Mark W. Grinstaff Physical Chemistry Chemical Physics, 2014, 16, 20608-20617 doi:10.1039/c4cp02594f "Recent Advances in Glycerol Polymers: Chemistry and Biomedical Applications." Heng Zhang and Mark W. Grinstaff Macromolecular Rapid Communications, 2014, 35, 1906-192 doi:10.1002/marc.201400389 "Bioinspired Systems in Supramolecular Chemistry and Nanotechnology - Introducing the Suprabio Themed Issue." Michel Camplo, Jean-Manuel Raimundo, Laurence Navailles, Mark W. Grinstaff, and Philippe Barthélémy New Journal of Chemistry, 2014, 38, 5120-5121 doi:10.1039/C4NJ90041C "A Reversible Supramolecular Assembly Containing Ionic Interactions and Disulfide Linkages." Xinrong Lin, Guilhem Godeau, and Mark W. Grinstaff New Journal of Chemistry, 2014, 38, 5186-5189 doi:10.1039/c4nj00895b "Synthesis of Tantalum Oxide Nanoparticles for Imaging Articular Cartilage Using X-Ray Computed Tomography: Visualization of Ex vivo Murine Tibia and Human Index Finger Cartilage." Jonathan D. Freedman, Hrvoje Lusic, Brian D. Snyder, and Mark W. Grinstaff Angewandte Chemie, 2014, 53, 8406–8410 doi:10.1002/anie.201404519 "Carboxylated Glucuronic Poly-amido-saccharides as Protein Stabilizing Agents." Sarah E. Stidham, Eric L. Dane, and Mark W. Grinstaff Journal of the American Chemical Society, 2014,136, 9544-9547 doi:10.1021/ja5036804 "Imparting Superhydrophobicity to Biodegradable Poly(lactide-co-glycolide) Electrospun Meshes." Jonah A. Kaplan, Hongyi Lei, Rong Liu, Robert Padera, Yolonda L. Colson, and Mark W. Grinstaff Biomacromolecules, 2014, 15, 2548-2554 doi:10.1021/bm500410h "Effect of Mechanical Convection on the Partitioning of an Anionic Iodinated Contrast Agent in Intact Patellar Cartilage." Vahid Entezari, Prashant N. Bansal, Rachel C. Stewart, Benjamin A. Lakin, Mark W. Grinstaff, and Brian D. Snyder Journal of Orthopaedic Research, 2014, 32, 1333-1340 doi:10.1002/jor.22662 "Photoactive Electrospun Polymeric Meshes: Spatiotemporally Wetting of Textured 3-Dimensional Structures." Joseph S. Hersey, Jonathan D. Freedman, and Mark W. Grinstaff Journal of Materials Chemistry B, 2014, 2, 2974-2977. doi:10.1039/C4TB00143E "Synthesis of Hydrophobic Carbohydrate Polymers and Their Formation of Thermotropic Liquid Crystalline Phases." Cynthia Ghobril, Benoît Heinrich, Eric L. Dane, and Mark W. Grinstaff ACS Macro Letters, 2014, 3, 359-363. doi:10.1021/mz5000703 "Embedded Multicellular Spheroids as a Biomimetic 3D Cancer Model for Evaluating Drug and Drug-device Combinations." Kristie M. Charoen, Brian Fallica, Yolonda L. Colson, Muhammad H. Zaman, and Mark W. Grinstaff Biomaterials, 2014, 35, 2264-2271. doi:10.1016/j.biomaterials.2013.11.038 "Terpolymerization of Benzyl Glycidyl Ether, Propylene Oxide and CO2 Using Binary and Bifunctional [rac-SalcyCoIIIX] Complexes and the Thermal and Mechanical Properties of the Resultant Poly(benzyl 1,2-glycerol-co-propylene carbonate)s and Poly(1,2-glycerol-co-propylene carbonate)s." Heng Zhang and Mark W. Grinstaff Journal of Applied Polymer Science, 2014. doi:10.1039/c3sc52777h "Synthesis of bioinspired carbohydrate amphiphiles that promote and inhibit biofilms" Eric L. Dane, Alicia E. Ballok, George A. O’Toole, Mark W. Grinstaff Chemical Science, 2014, 5, 551-557. doi:10.1039/c3sc52777h