个人简介

B.S. in Chemistry (with Honors), Indiana University, Bloomington, 1982 Ph.D. in Physical Chemistry, University of California, Berkeley, 1988.

研究领域

Physical Chemistry/Biological Chemistry

The Georgiadis Group’s research focuses on the development and use of novel label-free detection methods based on surface plasmon resonance (SPR) spectroscopy. Our current projects are focused around the development of novel label-free DNA microarray technologies. Areas of study include: Electric field effects at interfaces – Rapid mismatch discrimination by electric field induced denaturation DNA/protein interactions – screening methods for anti-tumor aptamers as tumor targeting reagents. DNA/drug interactions – kinetics of binding novel platinum anti-tumor drugs with oligonucleotides.

近期论文

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"Secondary structure effects on DNA hybridization kinetics: a solution vs. surface comparison" Yang Gao, Lauren K. Wolf, and Rosina M. Georgiadis, submitted. "Quantitative angle-resolved SPR imaging of DNA-DNA and DNA-drug kinetics" Lauren K. Wolf, Dominic E Fullenkamp and Rosina M. Georgiadis ( J. Amer. Chem. Soc. 127 (49): 17453-17459, 2005.) "Sequence-Dependent DNA Immobilization: Specific versus Nonspecific Contributions" Lauren K. Wolf, Yang Gao and Rosina M. Georgiadis (Langmuir 20(6) 3357-3361, 2004.) "Hybridization of Mismatched or Partially Matched DNA at Surfaces", Alexander W. Peterson, Lauren K. Wolf and Rosina M. Georgiadis, (J. Am. Chem. Soc. 124 (49) 14601-7 2002). "The effect of surface probe density on DNA hybridization", Alexander W. Peterson, Richard J. Heaton and Rosina M. Georgiadis, (Nucleics Acids Research. 29:(24) 5163-5168, 2001). "Electrostatic surface plasmon resonance: Direct electric field-induced hybridization and denaturation in monolayer nucleic acid films and label-free discrimination of base mismatches", Richard J. Heaton, Alexander W. Peterson and Rosina M. Georgiadis, (Proc Natl Acad Sci U S A. 98:(7) 3701-4, 2001). "Kinetic control of hybridization in surface immobilized DNA monolayer films", Peterson AW, Heaton RJ, Georgiadis R,(J. Am. Chem. Soc. 122(32) 7837-7838, 2000 ). "Quantitative measurements and modeling of kinetics in nucleic acid monolayer films using SPR spectroscopy", Georgiadis R, Peterlinz KP, Peterson AW ,(J. Am. Chem. Soc. 122 (13) 3166-3173, 2000 ). "Surface plasmon resonance spectroscopy as a probe of in-plane polymerization in monolayer organic conducting films",Georgiadis R, et al. , (Langmuir 16 (17) 6759-6762, 2000) . "Temperature-dependent refractive index determination from critical angle measurements: Implications for quantitative SPR sensing", Grassi JH, Georgiadis RM , (Analytical Chemistry 71(19) 4392-4396, 1999 ). "Quantitative SPR as a probe of adsorption, diffusion and self-assembly of biopolymers and oligonucleotides at interfaces", R. Georgiadis, in Laser Techniques in Condensed Phase and Biological Systems (SPIE Vol. 3273, p. 102-109 (1998). "Observation of hybridization and dehybridization of thiol-tethered DNA using two-color surface plasmon resonance spectroscopy", K. A. Peterlinz, R. M. Georgiadis, T. M. Herne, and M. J. Tarlov, (J. Am. Chem. Soc., 119, 3401 (1997). "Comment on characterization of self-assembled monolayers on silver and gold using surface plasmon resonance spectroscopy", K. A. Peterlinz and R. Georgiadis, (J. Phys. Chem. B, 101, 8041-8042 (1997). "Two-color approach for determination of thickness and dielectric constant of thin films using surface plasmon resonance spectroscopy", K. A. Peterlinz and R. Georgiadis, (Opt. Commun., 130, 260-266 (1996). "In situ kinetics of self-assembly by surface plasmon resonance spectroscopy", K. A. Peterlinz and R. Georgiadis, (Langmuir, 12, 4731-4740 (1996).