个人简介

Sean Elliott investigates the connection between biological electron transfer chemistry and function of redox active proteins and enzymes, by using direct electrochemistry and spectroscopy. He joined the Department of Chemistry in 2002, following an EMBO Post-doctoral Fellowship at the University of Oxford. A recipient of the Gitner and Templeton Awards within the College of Arts and Sciences, he was promoted to Associate Professor of Chemistry in 2008.

研究领域

Biological Chemistry/Inorganic Chemistry

The Elliott Group investigates the interplay between biological systems and redox-active species (e.g., metal ions, organic radicals, disulfide bonds, reactive oxygen species). Our emphasis is on the kinetic and thermodynamic basis for catalytic redox chemistry, as well as the molecular impact of metal ions and reactive oxygen species upon cells.

近期论文

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Levin BD, Walsh KA, Sullivan KK, Bren LK, Elliott SJ, "Methionine Ligand Lability of Homologous Monoheme Cytochromes c", Inorganic Chemistry, accepted. [DOI] Hu W, Song H, Sae Her A, Bak DW, Naowarojna N, Elliott SJ, Qin L, Chen X, Liu P, "Bioinformatic and Biochemical Characterizations of C-S Bond Formation and Cleavage Enzymes in the Fungus Neurospora crassa Ergothioneine Biosynthetic Pathway," Organic Letter, 2014, 16(20): 5382-5385. Judd ET, Stein N, Pacupheco AA, Elliott SJ, "Hydrogen Bonding Networks Tune Proton-Coupled Redox Steps During the Enzymatic Six-electron Conversion of Nitrite to Ammonia," Biochemistry, 2014, 53 (35): 5638-5646. Funk MA, Judd ET, Marsh ENG, Elliott SJ, Drennan CL, "Structures of benzylsuccinate synthase elucidate roles of accessory subunits in glycyl radical enzyme activation and activity," PNAS, 2014, 111(28): 10161-10166. Bak DW and Elliott SJ, "Alternative FeS cluster ligands: tuning redox potentials and chemistry," Current Opinions in Chemical Biology, 2014, 19: 50-58. Bak DW and Elliott SJ, "Conserved hydrogen bond networks tune FeS cluster binding and structural stability," Biochemistry, 2013, 52(27): 4687-4696. Duncan GGM, Marritt SJ, Firer-Sherwood MA, Shi L, Richardson DJ, Evans SD, Elliott SJ, Butt JN, Jeuken LJC. "Protein-Protein Interaction Regulates the Direction of Catalysis and Electron Transfer in a Redox Enzyme Complex," J. Am. Chem. Soc., 2013,135 (28):10550-10556. Bewley KD, Ellis KE, Firer-Sherwood MA, Elliott SJ. "Multi-heme proteins: Nature’s electronic multi-purpose tool," Biochimica et Biophysica Acta - Bioenergetics, 2013, 1827 (8-9): 938-94. Judd ET, Youngblut M, Pacecho AA, Elliott SJ. "Direct electrochemistry of Shewanella oneidensis cytochrome c nitrite reductase: evidence for interactions across the dimeric interface," Biochemistry, 2012, 51 (51):10175-85. Ellis KE, Frato KE, Elliott SJ. "Impact of Quarternary Structure upon Bacterial Cytochrome c Peroxidases: does homodimerization matter?" Biochemistry, 2012, 51(50): 10008-10016. Hamill MJ, Jost M, Wong C, Bene NC*, Drennan CL, Elliott SJ. "Electrochemical characterization of Escherichia coli adaptive response protein AidB", International Journal of Molecular Sciences, 2012, 13(12), 16899-16915. Bewley KD, Firer-Sherwood MA, Mock JY*, Ando N, Drennan CL, Elliott SJ. "Mind the gap: diversity and reactivity of multiheme cytochromes of the MtrA/DmsE family," Transactions of the Biochemical Society, 2012, 40(6), 1268-1273. Goldman PJ, Ryan KS, Hamill MJ, Howard-Jones AR, Walsh CT, Elliott SJ, Drennan CL. "Unusual Role for a Mobile Flavin in a StaC-like Indolocarbazole Biosynthetic Enzyme," Chemistry & Biology, 2012, 19(7), 855-865. Seidel J, Hoffmann M, Ellis KE, Seidel A, Spatzal T, Gerhardt S, Elliott SJ, Einsle O. "MacA is a Second Cytochrome c Peroxidase of Geobacter sulfurreducens", Biochemistry, 2012, 50(21), 4513-20. Youngblut M, Judd EJ, Srajer V, Sayyed B, Groelzer T, Elliott SJ, Schmidt M, Pacheco AA. "Laue crystal structure of Shewanella oneidensis cytochrome c nitrite reductase from a high-yield expression system", Journal of Biological Inorganic Chemistry, 2012, 17(4), 674-662. Pulcu GS, Frato KE, Gupta R, Hsu H.-R., Levine GA, Hendrich MP, Elliott SJ. "The Cytochrome c Peroxidase from Shewanella oneidensis Requires Reductive Activation," Biochemistry, 2012, 52: 974-985. Hamill, M.J.; Jost, M.; Wong, C.Y.; Elliott, S.J.; Drennan, C.L. "Flavin Induced Oligomerization in Escherichia coli Adaptive Response Protein AidB," Biochemistry, 2011, 51: 10159-10169. Levin, B.D.; Can, M.; Bren, K.L.; Elliott, S.J. "Methionine Lability in Bacterial Monoheme Cytochromes c: an electrochemical study," Journal of Physical Chemistry - B, 2011, 11718-11726. Firer-Sherwood, M.A.; Ando, N.; Drennan, C.L.; Elliott, S.J. "Solution-based Structural Analysis of the Decaheme Cytochrome MtrA, by Small Angle X-Ray Scattering and Analytical Ultracentrifugation," Journal of Physical Chemistry - B, 2011, 11208-1114. Ellis, K.E.; Seidel, J.; Einsle, O.; Elliott, S.J. "Geobacter sulfurreducens Cytochrome c Peroxidases: electrochemical classification of catalytic mechanisms," Biochemistry, 2011, 51: 4513-4520. Firer-Sherwood, M.A.; Bewley, K.D.; Mock, J.Y.; Elliott, S.J. "Tools for Resolving Complexity in the Electron Transfer Networks of Multiheme Cytochromes" Metallomics, 2011, 3:344-348.