个人简介

B.A., University of Science & Technology of China, 1999 Ph.D., Stanford University, 2005 Postdoctoral Associate, Texas A&M University, 2008 Postdoctoral Fellow, Harvard University, 2011

研究领域

Physical Chemistry/Biological Chemistry

Our laboratory, established in summer 2011 in the BU Photonics Center, aims to answer these and other surface chemistry questions on the molecular level. We are generally interested in understanding how molecules behave on soft and/or wet surfaces. The insights gained from studying those systems will impact the biological, materials, and environmental sciences. Our current investigations relate to these areas include: Biophysics: adsorption of ions, osmolytes, peptides, and small-molecule drugs on surfaces of proteins and cell membranes. Materials science: bio-fouling and frictional behaviors on surfaces of biomaterials and other soft materials (e.g., hydrogels, elastomeric polymers, and artificial tissues). Environmental science: reactions on surfaces of aqueous electrolytic solutions (i.e. salty water, including sea surface, ice surface, aerosols, etc), and on surfaces of non-aqueous solutions with complex chemistry (e.g., crude oil). On the technical side, we are developing and improving physical and analytical techniques that are uniquely suitable to study those soft and wet surfaces, including surface-specific ultrafast laser spectroscopy and microscopy. Our research is highly interdisciplinary and collaborative, spanning many science and engineering fields, including (but not limited to) physical chemistry, surface science, biophysics, materials science, and biomedical engineering. Individuals interested in joining our group or simply knowing more about us and our research should contact Dr. Xin Chen directly.

近期论文

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WJ Choi, M Hashimoto, AK Ellerbee, X Chen, K Bishop, GM Whitesides "Navigating networks based on local information and cooperative interactions." Lab Chip 2011, accepted. F Illievski, A Mazzeo, R Shepherd, X Chen, GM Whitesides "Soft robots for chemists.", Angew. Chem. In. Ed. 2011, 50, 1890-1895. YH Hu, X Chen, GM Whitesides, JJ Vlassak, ZH Suo "Indentation of polydimethylsiloxane submerged in organic solvents." J. Mater. Res. 2011, 26, 785-795. SJ Vella, X Chen, SW Thomas III, X Zhao, ZH Suo, GM Whitesides "The determination of the location of contact electrification-induced discharge events." J. Phy. Chem. C 2010, 114, 20885-20895. X Chen, SC Flores, SM Lim, YJ Zhang, TL Yang, J Kherb, PS Cremer "Specific anion effects on water structure adjacent to protein monolayers." Langumir 2010, 26, 16447-16454. JL Gong, DJ Lipomi, JD Deng, ZH Nie, X Chen, NX Randall, R Nair, GM Whitesides, "Micro- and nanopatterning of inorganic and polymeric substrates by indentation lithography." Nano Lett. 2010, 10, 2702-2708. X Chen, DA Walthall, JI Brauman "Geometry dependence of the ring-opening E2 reaction in lactones." J. Phy. Chem. A 2010, 114, 1392-1397. ZH Nie, CA Nijhuis, JL Gong, X Chen, A Kumachev, AW Martinez, M Narovlyansky, GM Whitesides "Electrochemical sensing in paper-based microfluidic devices." Lab Chip 2010, 10, 477-483. X Chen, CK Regan, SL Craig, EH Krenske, KN Houk, WL Jorgensen, JI Brauman "Steric and solvation effects in ionic SN2 reactions." J. Am. Chem. Soc. 2009, 131, 16162-16170. JX Chen, WS Liao, X Chen, TL Yang, SE Wark, DH Son, JD Batteas, PS Cremer, "Evaporation-induced assembly of quantum dots into nanorings." ACS Nano 2009, 3, 173- Fan YB, X Chen, LJ Yang, PS Cremer, YQ Gao "On the structure of water at the aqueous/air interface." J. Phy. Chem. B 2009, 113, 11672-11679. Sagle LB, Zhang YJ, Litosh VA, X Chen, Cho Y, PS Cremer "Investigating the hydrogenbonding model of urea denaturation." J. Am. Chem. Soc. 2009, 131, 9304-9310. WS Liao, X Chen, TL Yang, ET Castellana, J Chen, PS Cremer "Benchtop chemistry for the rapid prototyping of label-free biosensors: Transmission localized surface plasmon resonance platforms." Biointerphases 2009, 4, 80-85. X Chen, JI Brauman "Hydrogen bonding lowers intrinsic nucleophilicity of solvated nucleophiles." J. Am. Chem. Soc. 2008, 130, 15038-15046.