个人简介

BA/MA in Chemistry, Johns Hopkins University, 1979 MA/MPhil/PhD, Columbia University, 1985 Postdoctoral Fellow, Harvard University, 1985-87

研究领域

Biological Chemistry/Inorganic Chemistry

The Caradonna research group is interested in understanding the mechanism of action of non-heme iron metalloproteins, with a focus on the chemistry of metalloenzyme active sites involved in biological oxidation reactions. Our efforts span the continuum from the investigation of small molecule synthetic complexes that catalyze oxygen atom transfer reactions, to the characterization of an interesting class of iron/pterin-dependent aromatic amino acid hydroxylases (phenylalanine, tyrosine, and tryptophan hydroxylases), to the computational design of functional metalloproteins (iron-sulfur-based electron transfer clusters, Fe and Mn superoxide dismutanse). A broad-based approach, including chemical, molecular biological, and biophysical (spectroscopic) techniques, is used to develop a global understanding of the intrinsic characteristics of the active site metal centers and the role played by the protein matrix in regulating, modulating, and tuning these properties.

近期论文

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Foster, T. L.; Caradonna, J. P. Mono-nuclear, Non-heme Iron Oxygenases, Encyclopedia of Coordination Chemistry; Que, L., Ed.; Elsevier, Inc.: London, 2004; Vol. 8. Foster, T.; Caradonna, J. P. Fe2+ Catalyzed Heterolytic RO-OH Bond Cleavage and Substrate Oxidation: A Functional Synthetic Non-Heme Iron Monooxygenase System, J. Am. Chem. Soc.,2003,125, 3678. Kemsley, J. N.; Wasinger, E. C.; Datta, S.; Mitic, N.; Acharya, T.; Hedman, B.; Caradonna, J. P.; Hodgson, K. O.; Solomon, E. I. Spectroscopic and kinetic studies of PKU-inducing mutants of phenylalanine hydroxylase: Arg158Gln and Glu280Lys, Journal of the American Chemical Society, 2003,125, 5677. Wasinger, E. C.; Mitic, N.; Hedman, B.; Caradonna, J.; Solomon, E. I.; Hodgson, K. O. X-ray absorption spectroscopic investigation of the resting ferrous and cosubstrate-bound active sites of phenylalanine hydroxylase, Biochemistry, 2002,41, 6211. Kemsley, J. N.; Zaleski, K. L.; Mitic, N.; Datta, S.; Acharya, T.; Caradonna, J. P.; Solomon, E. I. Interaction of non-heme ferrous active sties with substrates: structure/function correlations for phenylalanine hydroxylase and bleomycin, Journal of Inorganic Biochemistry, 2001,86, 291. Wang, W. U.; Mitic, N.; Caradonna, J.; Peisach, J. EPR and ESEEM studies of phenylalanine Hydroxylase(PAH), Faseb Journal, 1999,13, A1499. Kemsley, J. N.; Zaleski, K. L.; Mitic, N.; Caradonna, J. P.; Hecht, S. M.; Solomon, E. I. Interaction of non-heme ferrous active sites with substrates: structure function correlations for phenylalanine hydroxylase and bleomycin, Journal of Inorganic Biochemistry, 1999,74, 189. Kemsley, J. N.; Mitic, N.; Zaleski, K. L.; Caradonna, J. P.; Solomon, E. I. Circular dichroism and magnetic circular dichroism spectroscopy of the catalytically competent ferrous active site of phenylalanine hydroxylase and its interaction with pterin cofactor, Journal of the American Chemical Society, 1999,121, 1528. Loeb, K. E.; Westre, T. E.; Kappock, T. J.; Mitic, N.; Glasfeld, E.; Caradonna, J. P.; Hedman, B.; Hodgson, K. O.; Solomon, E. I. Spectroscopic characterization of the catalytically competent ferrous site of the resting, activated, and substrate-bound forms of phenylalanine hydroxylase, Journal of the American Chemical Society, 1997,119, 1901.