研究领域
多年来一直致力于有机合成、有机合成方法学、药用高分子材料等领域的研究工作
近期论文
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1. Zhongling Feng, Gang Zhao, Lei Yu, David Gough, Stephen B. Howell, “Preclinical efficacy studies of a novel nanoparticle-based formulation of paclitaxel that out-performs Abraxane”, Cancer Chemotherapy and Pharmacology, 2010, 65, 923-930.
2. Xinghe Wang, Gang Zhao, Sang Van, Lei Yu, David Vera, Stephen B. Howell, “Pharmacokinetics and tissue distribution of PGGA-paclitaxel, a novel macromolecular formulation of paclitaxel, in nu/nu mice bearing NCI-460 lung cancer xenografts”, Cancer Chemotherapy and Pharmacology, 2010, 65, 515-526.
3. Changxing Liu, Gang Zhao, Jian Liu, Nianchun Ma, Zongyou Chen, David Gough, and Lei Yu, “Novel biodegradable lipid nano complex for siRNA delivery significantly improving the chemosensitivity of human colon cancer stem cells to paclitaxel” J. Controlled Release, 2009, 140(3), 277-283.
4. Wen-Tai Li, Anirban Mahapatra, David G. Longstaff, Jonathan Bechte, Gang Zhao, Patrick T. Kang, Michael K. Chan and Joseph A. Krzycki, “Specificity of Pyrrolysyl-tRNA Synthetase for Pyrrolysine and Pyrrolysine Analogs”, J. Mol. Biol. 2009, 385, 1156–1164.
5. Zhongling Feng, Gang Zhao and Lei Yu, “Neural Stem Cells and Alzheimer's Disease: Challenges and Hope”, Am J Alzheimers Dis Other Demen. 2009; 24; 52. (Invited review)
6. Mahapatra, A, Srinivasan, G, Richter, KB, Meyer, A, Lienard, T, Zhang, JK, Zhao, G, Kang, PT, Chan, M, Gottschalk, G, Metcalf, WW, Krzycki, JA, “Class I and class II lysyl-tRNA synthetase mutants and the genetic encoding of pyrrolysine in Methanosarcina spp.” Molecular Microbiology 2007, 5, 1306-1318.
7. Carine Bughin, Gang Zhao, Hugues Bienaym , Jieping Zhu, “5-Aminooxazole as an Internal Traceless Activator of C-Terminal Carboxylic Acid: Rapid Access to Diversely Functionalized Cyclodepsipeptides”, Chem. Eur. J. 2006, 4, 1174-1184.
8. Sherry K. Blight, Ross C. Larue, Anirban Mahapatra, David G. Longstaff, Edward Chang, Gang Zhao, Patrick T. Kang, Kari B. Green-Church, Michael K. Chan and Joseph A. Krzycki, “Direct charging of tRNACUA with pyrrolysine in vitro and in vivo”, Nature (London, United Kingdom), 2004, 431 (7006), 333-335.
9. Bing Hao, Gang Zhao, Patrick T. Kang, Jitesh A. Soares, Tsuneo K. Ferguson, Judith Gallucci, Joseph A. Krzycki, Michael K. Chan, ”Reactivity and chemical synthesis of L-pyrrolysine - the 22(nd) genetically encoded amino acid”, Chemistry & Biology 2004,11 (9): 1317-1324.
10. Gang Zhao, Xiaowen Sun, Hugues Bienaymé, and Jieping Zhu, “Activation of a Terminal Carboxylic Acid by an Internal Oxazole: A Novel Synthesis of Macrocyclodepsipeptide”, J. Am. Chem. Soc., 2001, 123, 6700.
11. Xiaowen Sun, Pierre Janvier, Gang Zhao, Hugues Bienaymé, and Jieping Zhu, “A Novel Multicomponent Synthesis of Polysubstituted 5-Aminooxazole and Its New Scaffold-Generating Reaction to Pyrrolo[3,4-b]pyridine”, Organic Letters, 2001, 6, 877.
12. Gang Zhao, Qingchuan Yang, and Thomas C. W. Mak, "Cyclic ether induced asymmetric cyclopalladation: synthesis, structural determination and alkyne insertion reaction of enantiopure planar chiral cyclopalladated derivatives of ferrocenylimines", Organometallics, 1999, 18, 3626.
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