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个人简介

刘颖,女,教授,博士生导师,国家级青年人才计划入选者。国家“优秀青年”基金、江苏省“杰出青年”基金、特聘教授、“双创人才”入选者。2004年从南京大学化学化工学院获得学士学位,2007年从南京大学化学化工学院获得分析化学硕士学位,2012年从美国加州大学河滨分校(University of California Riverside)获得分析化学博士学位。2012-2013年在德国博世集团北美研发中心(Robert Bosch llc Research and Technology Center)任研究员。2013-2015年在加州大学戴维斯分校(University of California Davis)生物医学工程系从事博士后研究工作,并兼任Sersense Inc.生物科技公司项目负责人。2015年7月起任南京大学化学化工学院化学系生命分析化学国家重点实验室教授。

研究领域

1)智能响应纳米材料合成与光学性能优化(DNA纳米材料、稀土无机纳米材料等) 2)生物分析与传感、智能响应的细胞成像与近红外二区活体成像 3)药物智能递送与疾病/癌症精准诊疗策略开发

近期论文

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Shiyi Bi, Wei Chen, Yanyun Fang, Yingfei Wang, Qing Zhang, Hongqian Guo, Huangxian Ju, Ying Liu* Cancer cell-selective membrane receptor clustering driven by VEGF secretion for in vivo therapy. J. Am. Chem. Soc. 2023, 145, 5041-5052. Xiaoxian Liu, Yifan Zhu, Caoxin Li, Yanyun Fang, Jinna Chen, Fei Xu, Yanqing Lu, Perry Ping Shum, Ying Liu*, Guanghui Wang* Sing-cell HER2 quantification via instant signal amplification in microdroplets Anal. Chim. Acta2023, 1251, 340976 Yingfei Wang, Wei Chen, Zhong Wang, Yu Zhu, Hongxia Zhao, Kun Wu, Jie Wu, Weihua Zhang, Qing Zhang, Hongqian Guo, Huangxian Ju, Ying Liu* NIR-II light powered asymmetric hydrogel nanomotors for enhanced immunochemotherapy Angew. Chem. Int. Ed. 2022,e202212866. Xiaobo Zhang, Weiwei Chen, Xiaoyu Xie, Yue Zhang, Zhicong Chao, Haibo Ma,Ying Liu*,Huangxian Ju* Energy pumping by surface collectors on upconversion nanoparticles for extended transfer and efficient self-evaluable photodynamic therapy CCS Chem.2022,4,1251-1262. Hongxia Zhao, Yuetong Li, Xiaobo Zhang, Kun Wu, Jiahang Lv, Cheng Chen, Huipu Liu, Zhuangzhi Shi, Huangxian Ju, Ying Liu* Orthogonal excitations of lanthanide nanoparticle up/down conversion emissions via switching NIR lights for in-vivo theranostics Biomaterials2022, 291, 121873 Yanyun Fang, Yawei Yan, Shiyi Bi, Yingfei Wang, Yue Chen, Peipei Xu*, Huangxian Ju, Ying Liu*Screening T-cell activity via a photodetachable DNA-copolymer nanocage and its therapeutic application Anal. Chem.2022, 94, 13205-13214. Yuchen Zhang, Xing Xing, Hongxia Zhao, Jing Jiang, Ying Liu, Zhenda Lu* Printed hybrid upconversion/perovskite nanoparticle cluster and its individual photoluminescence imaging Adv. Optical Mater. 2022, 2201841. Jingxing Guo, Ying Liu, Huangxian Ju*, Guangming Lu* From lab to field: surface-enhanced raman scattering based sensing strategies for on-site analysis. Trends Anal. Chem. 2022, 146,116488. Yuetong Li, Yuxin Xie, Yue Zhang, Hongxia Zhao, Huangxian Ju, Ying Liu* DNA nanomachine activation and Zn2+ imaging in living cells with single NIR irradiation Anal. Chim. Acta2022, 1221, 340149 Xinyu Jin, Hongxia Zhao, Zhicong Chao, Xiaofeng Wang, Qing Zhang*, Huangxian Ju, Ying Liu* Self-assembled cupric oxide nanoclusters for highly efficient chemodynamic therapy Chem. Asian. J. 2022, e202200296 Yue Zhang, Weiwei Chen, Yanyun Fang, Xiaobo Zhang, Ying Liu*,Huangxian Ju* Activating a DNA nanomachine via computation across cancer cell membranes for precise therapy of solid tumors J. Am. Chem. Soc. 2021, 143, 15233-15242. Yuling He, Shuwen Guo, Yue Zhang, Ying Liu*, Huangxian Ju NIR-II reinforced intracellular cyclic reaction to enhance chemodynamic therapy with abundant H2O2 supply Biomaterials 2021, 275, 120962. Yue Zhang, Xiaobo Zhang, Weiwei Zhen, Yuling He, Ying Liu*, Huangxian Ju* Self-assembled micelle responsive to quick NIR light irradiation for fast drug release and highly efficient cancer therapy J. Control Release 2021, 336, 469-479. Yanyun Fang, Yuetong Li, Yuyi Li, Rong He, Yue Zhang, Xiaobo Zhang, Ying Liu*, Huangxian Ju In situ protease secretion visualization and metastatic lymph nodes imaging via a cell-membrane anchored upconversion nanoprobe Anal. Chem.2021, 93, 7258-7265. Yuling He, Shuwen Guo, Yue Zhang, Ying Liu*, Huangxian Ju Near-infrared photo-controlled permeability of a biomimetic polymersome with sustained drug release and efficient tumor therapy ACS Appl. Mater. Interfaces2021, 13, 14951-14963. Yuling He, Xinyu Jin, Shuwen Guo, Hongxia Zhao,Ying Liu*, Huangxian Ju Conjugated polymer-ferrocence nanoparticle as an NIR-II light powered nanoamplifier to enhance chemodynamic therapy ACS Appl. Mater. Interfaces2021, 13, 31452-31461. Yue Zhang, Weiwei Chen, Yue Zhang, Xiaobo Zhang, Ying Liu*, Huangxian Ju* Near-infrared photo-switched microRNA amplifier for precise photodynamic therapy of early-stage cancers Angew. Chen. Int. Ed.2020 59, 21454-21459. Yue Zhang, Yue Zhang, Xiaobo Zhang, Yuyi Li, Yuling He, Ying Liu*, Huangxian Ju Photo zipper locked DNA nanomachine with internal standard for precise miRNA imaging in living cells Chem. Sci. 2020, 11, 6289-6296. Jingxing Guo, Ying Liu, Yuanjiao Yang, Yumei Li, Ruiyong Wang, Huangxian Ju* A filter supported surface-enhanced raman scattering "nose" for point-of-care monitoring of gaseous metabolites of bacteria Anal. Chem. 2020, 92, 5055-5063. Yuyi Li, Xiaobo Zhang, Yue Zhang, Yue Zhang, Yuling He, Ying Liu*, Huangxian Ju Activatable photodynamic therapy with therapeutic effect prediction based on a self-correction upconversion nanoprobe. ACS Appl. Mater. Interfaces 2020, 12, 19313-19323. Yingfei Wang, Yuyi Li, Yue Zhang, Kewei Ren, Huangxian Ju, Ying Liu* Express and sensitive detection of multiple miRNAs via DNA cascade reactors functionalized photonic crystal array. Sci. China Chem.2020, 63, 731-740. Yue Zhang, Yue Zhang, Guobin Song, Yuling He, Xiaobo Zhang, Ying Liu*, Huangxian Ju* A DNA-Azobenzene nanopump fueled by upconversion luminance for controllable intracellular drug release Angew. Chem. Int. Ed.2019, 58, 18207-18211. Xiaobo Zhang, Weiwei Chen, Xiaoyu Xie, Yuyi Li, Desheng Chen, Zhicong Chao, Chenghui Liu, Haibo Ma, Ying Liu*, Huangxian Ju* Boosting luminance energy transfer efficiency in upconversion nanoparticles with an energy-concentrating zone Angew. Chem. Int. Ed.2019, 58, 12117-12122. Yuling He, Shuwen Guo, Lina Wu, Pengwen Chen, Leyong Wang, Ying Liu*, Huangxian Ju* Near-infrared boosted ROS responsive siRNA delivery and cancer therapy with sequentially peeled upconversion nano-onions Biomaterials2019, 225, 119501 Jingxin Guo, Zhihao Zhong, Yumei Li, Ying Liu*, Ruiyong Wang*, Huangxian Ju* “Three-in-One” SERS adhesive tape for rapid sampling, release, and detection of wound infectious pathogens ACS Appl. Mater. Interfaces 2019, 11, 36399-36408. Lina Wu, Yingfei Wang, Rong He, Yue Zhang, Yuling He, Chao Wang, Zhenda Lu, Ying Liu*, Huangxian Ju Fluorescence hydrogel array based on interfacial cation exchange amplification for highly sensitive microRNA detection Anal. Chim. Acta 2019, 1080, 206-214.

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