个人简介

B.A., University of California at Santa Cruz, Phi Beta Kappa Ph.D., University of California at Berkeley Postdoctoral Fellow, Sloan-Kettering Institute

研究领域

Chemical Biology, Glycomics, Molecular Recognition, Organic Chemistry.

Carbohydrates are critical in a myriad of important biological processes including intra-cellular communication, inflammation and bacterial and viral infections. Despite mounting evidence for the impact of glycosylation in modern biology,the complexity of glycoforms and the lack of methods to observe them hinder our understanding of these biomolecules. Our laboratory merges chemistry and biology to create and apply new methods to the study of glycosylation. These include the creation and utilization of new probes for glycosylation, cellular sensors and array technologies. We focus on three major areas of interest 1 The study of beta-O-N-acetyl-D-glucosamine function,a cytosolic carbohydrate modification analogous to phosphorylation, using new in vivo and in vitro methods 2 Invention of novel tools and methods for the profiling of cell-surface carbohydrate compositions 3 Application of bioinformatic and systems-based approaches to understanding the role of carbohydrates in metastasisand microbial pathogenesis.

近期论文

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Mahal, L.K. Catching Bacteria with Sugar. Chem. & Biol., 2004, 11, 1602-1604. Pilobello, K.T.; Krishnamoorthy, L.; Slawek, D.; Mahal, L.K. Development of a Lectin Microarray for the Rapid Analysis of Protein Glycopatterns. ChemBioChem 2005, 6, 985-989. Hsu, K.-L.; Pilobello, K.T; Mahal, L.K. Analyzing the dynamic bacterial glycome with a lectinmicroarray approach. Nature Chem. Biol. 2006, 2, 153-157. Sanki, A.; Mahal, L.K. A One-Step Synthesis of Azide-Tagged Carbohydrates: VersatileIntermediates for Glycotechnology. Synlett 2006, 3, 455-459. Hsu, K.-L.; Mahal, L. K. Profiling the sweet structures of the bacterial glycome. Nature Protocols, 2006, 1, 543-549. Carrillo, L.D.; Krishnamoorthy, L.; Mahal, L.K. A Cellular FRET Sensor for β-O-GlcNAc, a Dynamic Carbohydrate Modification Involved in Signaling, J. Am. Chem. Soc., 2006, 128, 14768-14769. Pilobello, K.T.; Mahal, L.K. Deciphering the glycocode: the complexity and analytical challenge of glycomics, Curr. Opin. Chem. Biol., 2007 11, 300-305. Pilobello, K.T.; Slawek, D.; Mahal, L.K. A ratiometric lectin microarray approach to analysis of the dynamic mammalian glycome, Proc. Natl. Acad. Sci., USA, 2007, 104, 10534-10539. Pilobello, K.T.; Mahal, L.K. Lectin Microarrays for Glycoprotein Analysis, Methods Mol. Biol., 2008, 385, 193-203. Mahal, L.K. Glycomics: Towards Bioinformatic Approaches to Understanding Glycosylation, Anti-Cancer Agents Med. Chem. 2008, 8, 37-51. Hsu, K.-L.; Gildersleeve, J.C.; Mahal, L.K. A simple strategy for the creation of a recombinant lectin microarray, Mol. BioSystems, 2008, 4, 654-662. Krishnamoorthy, L.; Bess, J.W.; Preston, A.B.; Nagashima, K.; Mahal, L.K. HIV-1 and microvesicles from T cells share a common glycome, arguing for a common origin, Nature Chem. Biol. 2009 5, 244-250. Hsu K.L.; Mahal L.K. Sweet tasting chips: microarray-based analysis of glycans. Curr Opin Chem Biol. 2009. 13, 427-432. Lebrilla C.B.; Mahal L.K. Post-translation modifications. Curr Opin Chem Biol. 2009 13, 373-374. Krishnamoorthy L.; Mahal L.K. Glycomic analysis: an array of technologies. ACS Chem Biol. 2009, 4, 715-732. Propheter, D.C.; Hsu, K.-L.; Mahal, L.K. Fabrication of an Oriented Lectin Microarray, ChemBioChem, 2010, 11, 1203-1207. Hsu, KL; Pilobello, K.; Krishnamoorthy, L; Mahal, L.K., Ratiometric lectin micorarray analysis of the mammalian cell surface glycome. Methods Mol. Biol. 2011, 671, 117-31. Carillo, L.D.; Froemming, J.A.; Mahal, L.K., Targeted in Vivo O-GlcNAc Sensor Reveals Discrete Compartment-specific Dynamics During Signal Transduction. J. Biol. Chem. 2011, 286, 6650-6658. Krishnamoorthy, L.K.; Mahal, L.K., Lectin Microarrays: Simple Tools for the Analysis of Complex Glycans, chapter in Functional and Structural Proteomics of Glycoproteins, eds. Owens, R.J; Nettleship, J.E., 2011, Springer Verlag. Propheter, D.C.; Mahal, L.K. Orientation of GST-tagged lectins via in situ surface modification to create an expanded lectin microarray for glycomic analysis. Mol. Biosystems 2011, 7, 2114-7.