个人简介

Born 1937; B.S. (1960), M.S. (1962) Seoul National University, Korea; Ph.D. University of Pittsburgh (1966); Research Associate M.I.T. (1966-70); Senior Research Scientist M.I.T. (1970-72); Assistant and Associate Professor, Biochemistry, Duke University School of Medicine (1972-78); Professor, University of California, Berkeley (1978- ); Faculty Senior Scientist, Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley (1979- ); Fulbright Fellow (1962); Sidhu Award (1970); N.I.H. Research Career Development Award (1976-79); Miller Research Professor ( UC Berkeley, 1983); Guggenheim Fellow (1985); E.O. Lawrence Award (US Department of Energy, 1987); Princess Takamatsu Award (Tokyo, Japan, 1989); The HoAm Prize ( Samsung Foundation, Korea, 1994); Fellow, American Academy of Arts & Sciences (1994); Member, National Academy of Sciences (1994); Korean Academy of Science and Technology Prize in Science ( Korea, 2000); Legacy Laureate Award, University of Pittsburgh, Pittsburgh, PA (2005); The Pride of Seoul National Univ. Alumni Award (Seoul, Korea, 2006); Department of Chemistry Alumni Award, Univ. of Pittsburgh, Pittsburgh, PA (2008); Member American Society of Biological Chemists, American Crystallography Association, American Chemical Society, and Biophysical Society

研究领域

Chemical Biology

(1) Biophysical, biochemical and computational methods are used to understand structure-function relationships of proteins of therapeutic value or proteins involved in cell movement, cell differentiation and stem cell pluripotency; (2) Development and application of computational genomics methods for understanding the demographics and evolution of proteins, genes, and whole genome sequences.

近期论文

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Chandonia, J. -M., Kim, S. -H., & Brenner, S. E. Target selection and deselection at the Berkeley Structural Genomics Center. Prot. Struc. Func. & Bio. 62: 356-370. (2006). Kim, J. -S., Shin, D. -H., Pufan, R., Huang, C., Yokota, H., Kim, R., & Kim, S. -H. Crystal structure of ScpB from Chlorobium tepidum, a protein involved in chromosome partitioning. Prot. Struc. Func. & Bio. 62: 322-328. (2006). Sims, G. E. & Kim, S. -H. A method for evaluating the structural quality of protein models by using HOPP scoring. Proc. of the Nat. Acad. Sciences. 103(12): 4428-4432. (2006). Chandonia, J. -M. & Kim, S. -H. Structural proteomics of minimal organisms: Conservation of protein fold usage and evolutionary implications. BMC Structural Biology. 6:7 (2006). Kim, S. -H., Shin, D. -H., Liu, J., Oganesyan, V., Chen, S., Xu, Q. S., Kim, J. -S., Das, D., Schulze-Gahmen, U., Holbrook, S. R., Holbrook, E. L., Martinez, B., Oganesyan, N., DeGiovanni, A., Lou, Y., Henriquez, M., Huang, C., Jancarik, J., Pufan, R., Choi, I. -G., Chandonia, J. M., Hou, J., Gold, B., Yokota, H., Brenner, S. E., Adams, P. D. & Kim, R. Structural genomics of minimal organisms and protein fold space. J. Struc. Func. Gen.6: 63-70. (2005). Liu, J., Lou, Y., Yokota, H., Adams, P. D., Kim, R. & Kim, S. -H. Crystal structures of an NAD Kinase from Archaeglobus fulgidus in complex with ATP, NAD, or NADP. J. Mol. Biol. 354: 289-303. (2005). Oganesyan, N., Kim, S. -H. & Kim, R. On-column protein refolding for crystallization. J. Struc. Func. Gen. 6: 177-182. (2005). Schulze-Gahmen, U., Aono, S., Chen, S., Yokota, H., Kim, R., & Kim, S. -H. Structure of the hypothetical Mycoplasma protein MPN555 suggests a chaperone function. Acta Cryst. D61: 1343-1347. (2005). Xu, S. X., Jancarik, J., Lou, Y., Kuznetsova, K., Yakunin, A., Yokota, H., Adams, P., Kim, R., & Kim, S. H. Crystal structures of a phosphotransacetylase from Bacillus subtilis and its complex with acetyl phosphate. J. Struc. Func. Gen. 6: 269-279. (2005). Liu, J., Huang, C., Shin, D. -H., Yokota, H., Jancarik, J., Kim, J. -S., Adams, P. D., Kim, R., & Kim, S. -H. Crystal structure of a heat-inducible transcriptional repressor HrcA from Thermotoga maritima: Structural insight into DNA binding and dimerization. J. Mol. Biol.350: 987-996. (2005). Kim, S. -H., Shin, D. H., Wang, W., Adams, P. D., Chandonia, J. -M. Overview of structural genomics: landscape, premises, and current direction. Structural Genomics and High Throughput Structural Biology. (Ed. by Michael Sundstrom, et al). Taylor & Francis Group. pp.1-18. (2005). Oganesyan, V., Huang, C., Adams, P. D., Jancarik, J., Yokota, H., Kim, R., Kim, S. -H. Structure of a NAD kinase from Thermotoga maritima at 2.3 A resolution. Acta Cryst. F61: 640-646. (2005). Shin, D. H., Oganesyan, N., Jancarik, J., Yokota, H., Kim, R., Kim, S. -H. Crystal structure of a nicotinate phosphoribosyltransferase from Thermoplasma acidophilum. J. Bio. Chem. 280(18): 18326-18335. (2005). Oganesyan, V., Oganesyan, N., Adams, P. D., Jancarik, J., Yokota, H., Kim, R., Kim, S. -H. Crystal structure of the “PhoU-Like” phosphate uptake regulator from Aquifex aeolicus. J. Bacteriology. 187: 4238-4244. (2005). Liu, J., Oganesyan, N., Shin, D. -H., Jancarik, J., Yokota, H., Kim, R., Kim, S. -H. Structural characterization of an iron-sulfur cluster assembly protein Iscu in a Zinc-bound form. Proteins: Struct. Func. & Bioinf. 59: 875-881. (2005). Liu, J., Lou, Y., Yokota, H., Adams, P., Kim, R., Kim, S. -H. Crystal structure of a PhoU protein homologue: A new class of metalloprotein containing multinuclear iron clusters. J. Bio. Chem. 280 (16): 15960-15966. (2005). Kim, J. -S., DeGiovanni, A., Jancarik, J., Adams, P. D., Yokota, H., Kim, R., Kim, S. -H. Crystal structure of DNA sequence specificity subunit of a type I restriction-modification enzyme and its functional implications. Proc. of the Nat. Acad. Sciences. 102: 3248-3253. (2005). Hou, J., Jun, S. -R., Zhang, C., Kim, S. -H. Global mapping of the protein structure space and application in structure-based inference of protein function. Proc. of the Nat. Acad. Sciences. 102: 3651-3656. (2005). Card, G. L., Blasdel, L., England, B. P., Zhang, C., Suzuki, Y., Gillette, S., Fong, D., Ibrahim, P. N., Artis, D. R., Bollag, G., Milburn, M., Kim, S. -H., Schlessinger, J., Zhang, K. Y. J. A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design. Nature Biotech. (in press). (2005).