高卫平 - 北京大学

个人简介

Education 2000 - 2004 Ph.D. of Polymer Chemistry and Physics, Department of Polymer Science and Engineering, Peking University, Beijing, China. Advisors: Professor Qifeng Zhou and Professor Erqiang Chen 1997 - 2000 M.S. of Chemical Engineering, Qingdao Institute of Chemical Technology, Qingdao, China 1993 - 1997 B.Sc. of Chemical Engineering, Qingdao Institute of Chemical Technology, Qingdao, China Academic experiences 2019.1 - now Associate professor, Biomedical Engineering Department, Peking University, Beijing, China 2011.9 - 2019.1 Principal Investigator/Professor, Department of Biomedical Engineering, School of Medicine, Tsinghua University, China 2007.5 - 2011.8 Postdoctoral Associate, Department of Biomedical Engineering and Center for Biologically Inspired Materials and Material Systems, Duke University, USA 2005.3 - 2007.5 Center of Excellence (COE) Researcher, Institute for Chemical Research, Kyoto University, Japan

研究领域

My research goal is to design protein therapeutics and polymeric biomaterials, especially protein-polymer conjugates, for diagnosis and therapy of diseases, such as cancer, diabetes, infectious and cardiovascular diseases.

近期论文

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39. Zhuoran Wang, Jianwen Guo, Jiawei Sun, Ping Liang, Yan Wei, Xuliang Deng, Weiping Gao*. Thermoresponsive and protease-cleavable interferon-polypeptide conjugates with spatiotemporally-programmed two-step release kinetics for tumor therapy. Adv. Sci. 2019, 1900586, 1-8. (IF = 15.8) 38. Hanjun Hao, Mengmeng Sun, Pengyong Li, Jiawei Sun, Xinyu Liu, Weiping Gao*. In situ growth of a cationic polymer from the N-terminus of glucose oxidase to regulate H2O2 generation for cancer starvation and H2O2 therapy. ACS Appl. Mater. Interfaces 2019, 11, 9756-9762. (IF = 8.5) 37. Xuyang Sun, Mengmeng Sun, Miaomiao Liu, Bo Yuan, Weiping Gao, Wei Rao* Jing Liu*. Shape tunable gallium nanorods mediated tumor enhanced ablation through near-infrared photothermal therapy. Nanoscale 2019, 11, 2655-2667. (IF = 7.0) 36. Zhuoran Wang, Jianwen Guo, Jing Ning, Xiaoyu Feng, Xinyu Liu, Jiawei Sun, Xiangmei Chen, Fengmin Lu, Weiping Gao*. One-month zero-order sustained release and tumor eradication after a single subcutaneous injection of interferon alpha fused with a body-temperature-responsive polypeptide. Biomater. Sci. 2019, 7, 104-112. (IF = 5.9) 35. Pengyong Li, Mengmeng Sun, Zhikun Xu, Xinyu Liu, Wenguo Zhao, Weiping Gao*. Site-selective in situ growth-induced self-assembly of protein-polymer conjugates into pH-responsive micelles for tumor microenvironment triggered fluorescence imaging. Biomacromolecules 2018, 19, 4472-4479. (IF = 5.7) 34. Xinyu Liu, Mengmeng Sun, Jiawei Sun, Jin Hu, Zhuoran Wang, Jianwen Guo, Weiping Gao*. Polymerization induced self-assembly of a site-specific interferon -block copolymer conjugate into micelles with remarkably enhanced pharmacology. J. Am. Chem. Soc. 2018, 140, 10435-10438. (IF = 14.4) 33. Xuelin Wang, Wenhao Yao, Rui Guo, Xiaohu Yang, Jianbo Tang, Jie Zhang, Weiping Gao, Victoria Timchenko, Jing Liu*. Soft and moldable Mg-doped liquid metal for conformable skin tumor photothermal therapy. Adv. Healthcare Mater. 2018, 7, 1800318. (IF = 5.6) 32. Mengmeng Sun, Jianwen Guo, Hanjun Hao, Tong Tong, Kun Wang, Weiping Gao*. Tumour-homing chimeric polypeptide-conjugated polypyrrole nanoparticles for imaging-guided synergistic photothermal and chemical therapy of cancer. Theranostics 2018, 8, 2634-2645. (IF = 8.8) 31. Xinyu Liu, Jiawei Sun, Weiping Gao*. Site-selective protein modification with polymers for advanced biomedical applications. Biomaterials 2018, 178, 413-434. (IF = 8.8) 30. Weiping Gao*, Mengmeng Sun. Drug nanorods are potential new nanocarriers for intracellular protein delivery. Theranostics 2018, 8, 3872-3873. (IF = 8.8) 29. Xinyu Liu, Jin Hu, Jianwen Guo, Guilin Wang, Weiping Gao*. Temperature-responsive polymer conjugation of interferon- enhances antitumor efficacy. Acta Polym. Sin. 2018, 1, 90-98.（IF = 0.7） 28. Zhuoran Wang, Qiong He, Wenguo Zhao, Jianwen Luo*, Weiping Gao*. Tumor-homing, pH- and ultrasound-responsive polypeptide-doxorubicin nanoconjugates overcome doxorubicin resistance in cancer therapy. J. Control. Release 2017, 264, 66-75. (IF = 7.9) 27. Wenguo Zhao, Jin Hu, Weiping Gao*. Glucose oxidase-polymer nanogels for synergistic cancer-starving and oxidation therapy. ACS Appl. Mater. Interfaces 2017, 9，23528-23535. (IF = 8.1) 26. Guilin Wang, Jin Hu, Weiping Gao*. Tuning the molecular size of site-specific interferon-polymer conjugate for optimized antitumor efficacy. Sci. China Mater. 2017, 60， 563-570. (IF = 4.3) Note: This paper is an invited letter for SPECIAL ISSUE: Biomaterials for Therapeutic Delivery. 25. Mengmeng Sun, Dong Peng, Hanjun Hao, Jin Hu, Dongliang Wang, Kun Wang, Jing Liu, Ximin Guo, Yen Wei, Weiping Gao*. Thermally triggered in situ assembly of gold nanoparticles for cancer multimodal imaging and photothermal therapy. ACS Appl. Mater. Interfaces 2017, 9, 10453-10460. (IF = 8.1) 24. Linjia Su, Song Hu, Li Zhang, Zhuoran Wang, Weiping Gao, Jing Yuan*, Minghua Liu*. A fast and efficient replacement of CTAB with MUA on the surface of gold nanorods assisted by a water-immiscible ionic liquid. Small 2017, 13, 1602809. (IF = 8.9) 23. Xinyu Liu, Weiping Gao*. In situ growth of self-assembled protein-polymer nanovesicles for enhanced intracellular protein delivery. ACS Appl. Mater. Interfaces 2017, 9, 2023-2028. (IF = 8.1) 22. Jin Hu, Guilin Wang, Wenguo Zhao, Weiping Gao*. In situ growth of a C-terminal interferon-alpha conjugate of a phospholipid polymer that outperforms PEGASYS in cancer therapy. J. Control. Release 2016, 237, 71-77. (IF = 7.9) 21. Jin Hu, Guilin Wang, Wenguo Zhao, Xinyu Liu, Libin Zhang, Weiping Gao*. Site-specific in situ growth of an interferon-polymer conjugate that outperforms PEGASYS in cancer therapy. Biomaterials 2016, 96, 84-92. (IF = 8.8) Note: This paper has been highlighted by Tsinghua News. 20. Mengmeng Sun, Fei Liu, Yukun Zhu, Wansheng Wang, Jin Hu, Jing Liu, Zhifei Dai, Kun Wang, Yen Wei, Jing Bai, Weiping Gao*. Salt-induced Aggregation of Gold nanoparticles for photoacoustic imaging and photothermal therapy of cancer. Nanoscale 2016, 8, 4452-4457. (IF = 7.8) 19. Mengmeng Sun, Zuoran Wang, Weiping Gao*. Nanomaterials for image-guided tumor photothermal therapy. China Medical Devices， 2016，31（06）， 24-28. (Invited review) 18. Wenguo Zhao, Fei Liu, Yue Chen, Jing Bai, Weiping Gao*. Synthesis of well-defined protein-polymer conjugates for biomedicine. Polymer 2015, 66, A1-A10. (IF = 3.6)。 17. Jin Hu, Guilin Wang, Xinyu Liu, Weiping Gao*. Enhancing pharmacokinetics, tumor accumulation and antitumor efficacy by elastin-like polypeptide fusion of interferon alpha. Adv. Mater. 2015, 27, 7320-7324. (IF = 22) Note: This paper has been highlighted by Science China Materials, X-MOL and Tsinghua News. 16. Libin Zhang, Wenguo Zhao, Xinyu Liu, Guilin Wang, Yang Wang, Dong Li, Liangzhi Xie, Yan Gao, Haiteng Deng, Weiping Gao*. Site-selective in situ growth of fluorescent polymer-antibody conjugates with enhanced antigen detection by signal amplification. Biomaterials 2015, 64, 2-9. (IF = 8.8) Note: This paper has been highlighted by Tsinghua News. 15. Jin Hu, Lining Xie, Wenguo Zhao, Mengmeng Sun, Xinyu Liu, Weiping Gao* Design of tumor-homing and pH-responsive polypeptide-doxorubicin nanoparticles with enhanced anticancer efficacy and reduced side effects. Chem. Commun. 2015, 51, 11405-11408. (IF = 6.8) 14. Liao Peng, Huijuan Zhang, Anchao Feng, Meng Huo, Zilin Wang, Jin Hu, Weiping Gao and Jinying Yuan. Electrochemical redox responsive supramolecular self-healing hydrogels based on host-guest interaction. Polym. Chem. 2015, 6, 3652-3659. (IF = 5.5) 13. Jin Hu, Wenguo Zhao, Yan Gao, Mengmeng Sun, Yen Wei, Haiteng Deng, Weiping Gao*. Site-specific in situ growth of a cyclized protein-polymer conjugate with improved stability and tumor retention. Biomaterials 2015, 47, 13-19. (IF = 8.8) 12. Bo-wen Liu, Hang Zhou, Si-tong Zhou, Hui-juan Zhang, An-chao Feng, Chun-mei Jian, Jin Hu, Wei-ping Gao, Jin-ying Yuan*. Synthesis of Self-Assembly of CO2-Temperature Dual Stimuli-Responsive Triblock Copolymers. Macromolecules 2014, 47, 2938-2946. (IF = 5.8) 11. Liao Peng, Anchao Feng, Huijuan Zhang, Hong Wang, Chunmei Jian, Bowen Liu, Weiping Gao, Jinying Yuan*. Votage-responsive micelles based on the assembly of two biocompatible homopolymers. Polym. Chem. 2014, 5, 1751-1759. (IF = 5.5) 10. Yizhi Qi, Miriam Amiram, Weiping Gao, Dewey McCafferty, and Ashutosh Chilkoti*. Sortase-Catalyzed Initiator Attachment Enables High Yield Growth of a Stealth Polymer from the C Terminus of a Protein. Macromol. Rapid Commun. 2013, 34, 1256-1260. (IF = 4.9) 9. Weiping Gao, Donghua Xu, Dong Woo Lim, Stephen L. Craig, Ashutosh Chilkoti*. In situ growth of a thermoresponsive polymer of a genetically engineered elastin-like polypeptide. Polym. Chem. 2011, 2，1561-1566. (IF = 5.5) 8. Weiping Gao, Wenge Liu, Trine Christensen, Michael R. Zalutsky, Ashutosh Chilkoti*. In situ growth of a PEG-like polymer from the C-terminus of an intein fusion protein improves pharmacokinetics and tumor accumulation. Proc. Natl. Acad. Sci. USA 2010, 107, 16432-16437. (IF = 9.7) Note: This paper has been highlighted by Nature and Science-Business eXchange (SciBX). 7. Weiping Gao, Wenge Liu, J. Andrew Mackay, Michael R. Zalutsky, Eric J. Toone, Ashutosh Chilkoti*. In situ growth of a stoichiometric PEG-like conjugate at a protein’s N-terminus with significantly improved pharmacokinetics. Proc. Natl. Acad. Sci. USA 2009, 106, 15231–15236. (IF = 9.7) Note: This paper has been highlighted by media and journals such as Nature, Science Daily, and Science-Business eXchange(SciBX). 6. Yu Bai, Weiping Gao, Jingjing Yan, Yuguo Ma, Dehai Liang, Zichen Li, Bingyong Han, Wantai Yang, Erqiang Chen*. Co-aggregation process of poly(ethylene oxide)-b-polybutadiene/poly(acrylic acid) based on evolution of interpolymer hydrogen bonding in solutions. Polymer 2008, 49, 2099-2106. (IF = 3.6) 5. Weiping Gao, Yu Bai, Erqiang Chen*, Zichen Li*, Bingyong Han, Wantai Yang, Qifeng Zhou*. Controlling vesicle formation via interpolymer hydrogen-bonding complexation between poly(ethylene oxide)-block-polybutadiene and poly(acrylic acid) in solution. Macromolecules 2006, 39, 4894-4898. (IF = 5.8) 4. Weiping Gao, Yu Bai, Erqiang Chen*, Qifeng Zhou*. Crystallization and melting of poly(ethylene oxide) confined in nanostructured particles with cross-linked shells of polybutadience. Chinese J. Polym. Sci. 2005, 23, 275-284. (IF = 1.7) 3. Weiping Gao, Yu Bai, Erqiang Chen*, Qifeng Zhou*. Confined polymer crystallization and melting within shell-crosslinked nano-aggregates. Acta Polym Sin, 2004, 1, 317-320. (IF = 0.4) 2. Qiye Wu*, Xin Wang, Weiping Gao, Youliang Hu, Zongneng Qi. Unusual rheological behaviors of linear PE and PE/kaolin composite. J. Appl. Polym. Sci. 2001, 80, 2154-2161. (IF = 1.9) 1. Qiong Zhou*, Gao Weiping, Juntao Wang, Jakun Wang, Hongyui Zhen, Qiyie Wu. Compound mechanism of the endo-exothermic and exo-endothermic balanced blowing agent. J. Cell. Plast. 2000, 36, 126-147. (IF = 1.7)