个人简介
赵丽青,女,1979年11月出生,博士,副教授。1997年入学江南大学生物工程学院生物工程专业学习,2001年免试攻读环境工程硕士学位研究生,2003年免试攻读博士,2006年7月获江南大学发酵工程专业博士学位。2007年3月至2009年9月,在德国不来梅国际大学(Jacobs University)科学与工程学院Schwaneberg研究组做博士后,2009年11月至2010年4月,在基因港(香港)生物科技有限公司任资深科学家(Senior Scientist),2010年5月至今,历任深圳大学食品科学与工程系讲师、副教授、系主任。主要从事生物催化、酶工程、基因克隆、蛋白质定向进化、功能性食品等方面的研究工作,主持国家自然科学基金、德国留德回国专项基金、广东省自然科学基金、深圳市技术开发项目、 深圳市基础研发基金、深圳大学校基础研究基金、深圳市功能高分子重点实验室开放基金及广东环西生物科技有限公司的横向基金等,在国内外期刊发表论文二十余篇,申请国内发明专利5项
研究领域
从事生物催化、酶工程、基因克隆、蛋白质定向进化、功能性食品等方面的研究工作
主持科研/教研项目
1. 主持国家自然科学基金“半理性设计解除异丁香酚单加氧酶产物抑制的分子机制研究”(21606152, 2017.01-2019.12, 20万元)
2. 主持广东省自然科学基金—自由申请项目“异丁香酚单加氧酶产物抑制的分子机制及其活性聚集体的构建”(2016A030313053, 2016.01-2018.12,10万元)。
3. 主持深圳市技术开发项目“磷酸肌酸生物催化合成技术的研发”(CXZZ20150430093131635,2015.07-2017.06,150万元)。
4. 校方主持深圳市技术开发项目“超低分子肝素生产用酶技术研发”(CXZZ20150330141732458,2015.07-2017.06,150万元)。
5. 主持深圳市基础研究基金“通过异丁香酚单加氧酶的定向进化提高生物香草醛产量”(JCYJ20140418091413576,2014.12-2016.12,20万元)。
6. 主持广东环西生物科技有限公司横向项目“氨基酸与细营养理论及其他相关技术的开发”(2012.06-2015.05,18万元)。
7. 主持德国留德回国专项资助(No. 30992,2010.05-2012.04,1.44万欧元)。
8. 主持广东省教改项目 “深圳大学--邦泰生物工程(深圳)有限公司实习基地建设”(2015.06-2017.06,5万元)
近期论文
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1. Jianhui Li, Yiguang Wu*, Liqing Zhao*. Antibacterial activity and mechanism of chitosan with ultra high molecular weight. Carbohydrate Polymers. 2016. (IF4.074)
2. Jiang Yi*, Yuting Fan, Yuzhu Zhang, Liqing Zhao*. Characterization of catechin-α-lactalbumin conjugates and the improvement in β-carotene retention in an oil-in-water nanoemulsion. Food Chemistry. 2016, 205: 73-80. (IF3.391)
3. Jiang Yi*, Yuting Fan, Wallace Yokoyama, Yuzhu Zhang, Liqing Zhao*. Thermal degradation and isomerization of beta-carotene in oil-in-water nanoemulsions supplemented with natural antioxidants. Journal of Agricultural & Food Chemistry. 2016, 64(9):1970-1976. (IF2.912)
4. Jiang Yi, Yuting Fan, Wallace Yokoyama, Yuzhu Zhang, Liqing Zhao*. Characterization of milk proteins–lutein complexes and the impact on lutein chemical stability. Food Chemistry. 2016, 200: 91-97. (IF3.391)
5. Jiang Yi*, Fang Zhong, Yuzhu Zhang, Wallace Yokoyama, Liqing Zhao*. Effects of lipids on in vitro release and cellular uptake of β-carotene in nanoemulsion-based delivery system. Journal of Agricultural & Food Chemistry. 2015, 63: 10831−10837. (IF2.912)
6. Liqing Zhao, Yiguang Wu*, Shu Chen, Tao Xing. Preparation and characterization of cross-linked carboxymethyl chitin porous membrane scaffold for biomedical applications. Carbohydrate Polymers. 2015, 126: 150–155. ( IF 4.074)
7. Jiangxin Wang; Min Zeng; Wenlong Hao; Yongdong Zou; Mengliang Shi; Yongguang Jiang; Peng Xiao; Anping Lei; Zhangli Hu; Weiwen Zhang; Liqing Zhao*. Fatty acid and metabolomics profiling approaches differentiate heterotrophic and mixotrophic culture conditions in microalgal food supplement “Euglena”. BMC Biotechnology. 2016. (IF2.304)
8. Liqing Zhao, Shuang Cheng, Ying Wang, Liuyan Chen, Beibei Geng, Yiguang Wu*. The promotion of biotransformation from isoeugenol to vanillin by Lysinibacillus fusiformis with sol-gel chitosan membrane. Rare Metal Materials and Engineering. 2016. (IF 0.153).
9. Liqing Zhao, Rouxuan Chen, Yulin Chen, Jiamao Fang, Weibin Chen, Jufang Wang*. Ionic liquids improve the biotransformation of isoeugenol to vanillin by Bacillus fusiformis CGMCC1347. Medicine Sciences and Bioengineering. 2015, 811-816. (EI)
10. Liqing Zhao*, Guanhui Bao, Beibei Geng, Jiangning Song, Yin Li. Draft genome sequence of Lysinibacillus fusiformis strain SW-B9, a novel strain for biotransformation of isoeugenol to vanillin. Genome Announcements. 2015. 3(2): e00289-15.
11. Bang Chen, Hongjia Zhang, Wenying Xi, Liqing Zhao*, Li Liang*, Yantao Chen*. Unfolding mechanism of lysozyme in various urea solutions: Insights from fluorescence spectroscopy. Journal of Molecular Structure. 2014, 1076: 524-528. (IF 1.599)
12. Liqing Zhao, Jiamao Fang, Weibin Chen, Xiangdong Xiao*. Repeated batch biotransformation from isoeugenol to vanillin by immobilized Bacillus fusiformis cells in CSTR reactor. Applied Mechanics and Materials, 2012, 209-211:1170-1173.
13. Liqing Zhao, Güray Güven, Yin Li, Ulrich Schwaneberg*. First steps towards a Zn/Co(III)sep-driven P450 BM3 reactor. Applied Microbiology and Biotechnology, 2011, 91(4): 989-999. (IF3.425)
14. Liqing Zhao, Zhihao Sun*, Pu Zheng, Junyao He. Biotransformation of isoeugenol to vanillin by Bacillus fusiformis CGMCC1347 with the addition of resin HD-8. Process Biochemistry. 2006, 41(7): 1673-1676. ( IF 2.44)
15. Liqing Zhao, Zhihao Sun*, Pu Zheng, Leilei Zhu. Biotransformation of isoeugenol to vanillin by a novel strain, Bacillus fusiformis. Biotechnology Letters. 2005, 27: 1505-1509. ( IF 1.64)