个人简介

B.S. Chemistry University of California at Berkeley Ph.D. Chemistry University of California at Irvine Postdoctoral Fellow California Institute of Technology

研究领域

Bioorganic Chemistry and Chemical Biology

Proteins often utilize small folded domains for recognition of other proteins, DNA and RNA. The hypothesis guiding our research is that by mimicking these folded domains we can modulate the function of a particular protein with metabolically stable synthetic molecules. The manifestation of this hypothesis into specific and potent compounds that interfere with chosen targets in cellular and animal systems requires new computational and synthetic approaches. We seek to devise a systematic framework to evaluate and target protein-protein interactions with structured peptidic and nonpeptidic scaffolds designed to reproduce the critical interfacial features of proteins.

近期论文

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Watkins, A. M.; Arora, P. S. Structure-based inhibition of protein–protein interactions. Eur. J. Med. Chem. 2014, 87, Article in Press.[PDF] Watkins, A. M.; Arora, P. S. The anatomy of β-strands at protein-protein interfaces. ACS Chem. Biol. 2014, 9, 1747–1754.[PDF] Lao, B. B.; Grishagin, I.; Mesallati, H.; Brewer, T. F.; Olenyuk, B. Z.; Arora, P. S. Topographical Helix Mimics as In Vivo Modulators of Hypoxia-Inducible Signaling. Proc. Natl. Acad. Sci. USA 2014, 111, 7531-7536.[PDF] Lao, B. B.; Drew, K.; Guarracino, D. A.; Brewer, T. F.; Heindel, D. W.; Bonneau, R.; Arora, P. S. Rational Design of Topographical Helix Mimics as Potent Inhibitors of Protein-Protein Interactions. J. Am. Chem. Soc. 2014, 136, 7877–7888.[PDF] Miller, S. E.; Watkins, A. M.; Kallenbach, N. R.; Arora, P. S. Effects of side chains in helix nucleation differ from helix propagation. Proc. Natl. Acad. Sci. USA 2014, 111, 6636-6641.[PDF] Udomprasert, A.; Bongiovanni, M. N.; Sha, R.; Sherman, W. B.; Wang, T.; Arora, P. S.; Canary, J. W.; Gras, S. L.; Seeman, N. C. Amyloid fibrils nucleated and organized by DNA origami constructions. Nat. Nanotechnol. 2014, 9, 537-541.[PDF] Xie, X.; Piao, L.; Bullock, B. N.; Smith, A.; Su, T.; Zhang, M.; Teknos, T. N.; Arora, P. S.; Pan, Q. Targeting HPV16 E6-p300 interaction reactivates p53 and inhibits the tumorigenicity of HPV-positive head and neck squamous cell carcinoma. Oncogene 2014, 33, 1037-1046.[PDF] Miller, S. E.; Thomson, P. F.; Arora, P. S. Synthesis of hydrogen-bond surrogate alpha-helices as inhibitors of protein-protein interactions. Curr. Protoc. Chem. Biol. 2014, 6, 101-116.[PDF] Kushal, S.;‡ Lao, B. B.;‡ Henchey, L. K.; Dubey, R.; Mesallati, H.; Traaseth, N. J.; Olenyuk, B. Z.; Arora, P. S. Protein domain mimetics as in vivo modulators of hypoxia-inducible factor signaling. Proc. Natl. Acad. Sci. USA 2013, 110, 15602-15607.[PDF] ‡equal contribution Bergey, C. M.;‡ Watkins, A. M.;‡ Arora, P. S. HippDB: a database of readily targeted helical protein-protein interactions. Bioinformatics 2013, 29, 2806-2807.[PDF] ‡equal contribution Drew, K.; Renfrew, P. D.; Craven, T. W.; Butterfoss, G. L.; Chou, F.-C.; Lyskov, S.; Bullock, B. N.; Watkins, A.; Labonte, J. W.; Pacella, M.; Kilambi, K. P.; Leaver-Fay, A.; Kuhlman, B.; Gray, J. J.; Bradley, P.; Kirshenbaum, K.; Arora, P. S.; Das, R.; Bonneau, R. Adding Diverse Noncanonical Backbones to Rosetta: Enabling Peptidomimetic Design. PLoS One 2013, 8, e67051.[PDF] Raj, M.; Bullock, B. N.; Arora, P. S. Plucking the high hanging fruit: A systematic approach for targeting protein-protein interactions. Bioorg. Med. Chem. 2013, 21, 4051-4057. [PDF] Nickerson, S.; Joy, S. T.; Arora, P. S.; Bar-Sagi, D.: An Orthosteric Inhibitor of the RAS–SOS Interaction. In The Enzymes; Fuyuhiko, T., Channing, J. D., Eds.; Academic Press, 2013; Vol. 34; pp. 25-39.[PDF] Wang, X.; Bergenfeld, I.; Arora, P. S.; Canary, J. W. Reversible Redox Reconfiguration of Secondary Structures in a Designed Peptide. Angew. Chem. Int. Ed. 2012, 51, 12099-12101.[PDF] Patgiri, A.;‡ Joy, S. T.;‡ Arora, P. S. "Nucleation Effects in Peptide Foldamers." J. Am. Chem. Soc. 2012, 134,11495-11502.[PDF] ‡equal contribution Mahon, A. B.; Miller, S. E.; Joy, S. T.; Arora, P. S.: Rational Design Strategies for Developing Synthetic Inhibitors of Helical Protein Interfaces In Protein-Protein Interactions; Wendt, M. D., Ed.; Springer, 2012; pp 175. (Book Chapter) [Link] Miller, S. E.; Arora, P.S. "Reversible Alpha-Helix Formation Controlled By A Hydrogen Bond Surrogate." Tetrahedron 2012, 68, 4434-4437.[PDF] Mahon, A. B.; Arora, P. S. "End-Capped Alpha-Helices as Modulators of Protein Function." Drug Discovery Today: Technologies 2012, 9, e57-e62.[PDF] Mahon, A. B.; Arora, P. S. "Design, Synthesis and Protein-Targeting Properties of Thioether-Linked Hydrogen Bond Surrogate Helices." Chem. Commun. 2012, 48, 1416-1418.[PDF] Bullock, B. N.; Jochim, A. L.; Arora, P. S. "Assessing Helical Protein Interfaces for Inhibitor Design." J. Am. Chem. Soc. 2011, 133, 14220-14223.[PDF]