个人简介

Dr. Salomon did undergraduate studies at Case Western Reserve University, graduate studies at Stanford University, and postdoctoral studies at the Genomics Institute of the Novartis Research Foundation. He recently joined the faculty of Brown University where he is Assistant Professor of Molecular Biology, Cell Biology, and Biochemistry (MCB).

研究领域

LC/MS/MS/MS/mass spectrometry/phosphorylation/proteomics/signaling tandem MS

My interests include: elucidation of signaling networks relevant to human disease and exploring perturbations in phosphorylation patterns induced by pharmacological agents. Recently I described a mass spectrometric-based technique that allows efficient profiling of hundreds of phosphorylation sites over time from human total cellular lysates. This technique will be automated by implementation of a high-throughput phosphoproteomics platform to determine global cellular phosphorylation patterns. I intend to employ this platform to map complex signaling networks under normal and pathological conditions.

近期论文

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Helou, Ynes A, Salomon, Arthur R. Protein networks and activation of lymphocytes Current opinion in immunology. 2015; 33 : 78-85 Ji, Qinqin, Ding, Yiyuan, Salomon, Arthur R. SRC Homology 2 Domain-containing Leukocyte Phosphoprotein of 76 kDa (SLP-76) N-terminal Tyrosine Residues Regulate a Dynamic Signaling Equilibrium Involving Feedback of Proximal T-cell Receptor (TCR) Signaling Mol Cell Proteomics. 2015; 14 (1) : 30-40 Lamming DW, Demirkan G, Boylan JM, Mihaylova MM, Peng T, Ferreira J, Neretti N, Salomon A, Sabatini DM, Gruppuso PA. Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2). FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2014; 28 (1) : 300-15 Feng, B., Jiao, P., Helou, Y., Li, Y., He, Q., Walters, M. S., Salomon, A., Xu, H. Mitogen-Activated Protein Kinase Phosphatase 3 (MKP-3)-Deficient Mice Are Resistant to Diet-Induced Obesity Diabetes. 2014; 63 (9) : 2924-2934 Wimuttisuk, Wananit, West, Mark, Davidge, Brittney, Yu, Kebing, Salomon, Arthur, Singer, Jeffrey D. Novel Cul3 binding proteins function to remodel E3 ligase complexes BMC cell biology. 2014; 15 (1) : 28 Sanderson TH, Mahapatra G, Pecina P, Ji Q, Yu K, Sinkler C, Varughese A, Kumar R, Bukowski MJ, Tousignant RN, Salomon AR, Lee I, Hüttemann M. Cytochrome C is tyrosine 97 phosphorylated by neuroprotective insulin treatment. PLoS ONE. 2013; 8 (11) : e78627 Helou YA, Nguyen V, Beik SP, Salomon AR. ERK positive feedback regulates a widespread network of tyrosine phosphorylation sites across canonical T cell signaling and actin cytoskeletal proteins in Jurkat T cells. PLoS ONE. 2013; 8 (7) : e69641 Li Y, Nie Y, Helou Y, Ding G, Feng B, Xu G, Salomon A, Xu H. Identification of sucrose non-fermenting-related kinase (SNRK) as a suppressor of adipocyte inflammation. Diabetes. 2013; 62 (7) : 2396-409 DeNardo BD, Holloway MP, Ji Q, Nguyen KT, Cheng Y, Valentine MB, Salomon A, Altura RA. Quantitative phosphoproteomic analysis identifies activation of the RET and IGF-1R/IR signaling pathways in neuroblastoma. PLoS ONE. 2013; 8 (12) : e82513