刘启昆 - 北京大学 - 现代农学院

个人简介

2004-2008年复旦大学本科 (生命科学学院基地班) 2008-2014年美国宾夕法尼亚州立大学博士（导师：Michael J. Axtell） 2014-2019年美国加利福尼亚大学洛杉矶分校博士后（导师：Steven E. Jacobsen）

研究领域

基因转录激活的分子机制染色质的表观遗传修饰（DNA甲基化、组蛋白修饰、核小体的空间分布等）和转录因子共同参与调控了基因的表达活性。通常情况下，基因和转座子的表达活性受DNA甲基化修饰的强烈抑制。然而，在特定的遗传背景和环境胁迫下，基因会逃脱DNA甲基化修饰的转录抑制。通过遗传学、基因组学和细胞生物学手段，我们试图解析基因和转座子逃脱DNA甲基化抑制效应的分子机制，并回答基因如何由关闭到开启，哪些蛋白因子以何种方式参与了这一调控过程。植物再生的基因调控再生是植物已分化细胞通过细胞命运的改变完成损伤器官修复、新器官及个体发生的过程，也是植物通过遗传转化等基因工程手段完成性状改良的重要环节和瓶颈问题。在分子水平，成功再生的前提是调控发育的关键转录因子的再激活和重编程。本课题组立足于植物表观遗传和基因调控领域的积累，开发基因调控的分子工具，以提高重要经济作物的再生及遗传转化效率。

近期论文

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Zhang, Q., Wang, Z., Lu, X., Yan, H., Zhang, H., He, H., Bischof, S., Harris, C.J., and Liu, Q. (2023). DDT-RELATED PROTEIN4-IMITATION SWITCH alters nucleosome distribution to relieve transcriptional silencing in Arabidopsis. Plant Cell DOI: 10.1093/plcell/koad143 Liu, Q.*#, Bischof, S.*, Harris, C.J., Zhong, Z., Zhan, L., Nguyen, C., Rashoff, A., Barshop, W.D., Sun, F., Feng, S., et al. (2020). The characterization of Mediator 12 and 13 as conditional positive gene regulators in Arabidopsis. Nat Commun 11, 2798. Chen, M., Liu, Q., Gao, S.S., Young, A.E., Jacobsen, S.E., and Tang, Y. (2019). Genome mining and biosynthesis of a polyketide from a biofertilizer fungus that can facilitate reductive iron assimilation in plant. Proc Natl Acad Sci U S A 116, 5499-5504. Yan, Y., Liu, Q., Jacobsen, S.E., and Tang, Y. (2018a). The impact and prospect of natural product discovery in agriculture: New technologies to explore the diversity of secondary metabolites in plants and microorganisms for applications in agriculture. EMBO Rep 19. Yan, Y.*, Liu, Q.*, Zang, X.*, Yuan, S., Bat-Erdene, U., Nguyen, C., Gan, J., Zhou, J., Jacobsen, S.E., and Tang, Y. (2018b). Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action. Nature 559, 415-418. Zhang, Y.*, Harris, C.J.*, Liu, Q.*, Liu, W., Ausin, I., Long, Y., Xiao, L., Feng, L., Chen, X., Xie, Y., et al. (2018). Large-scale comparative epigenomics reveals hierarchical regulation of non-CG methylation in Arabidopsis. Proc Natl Acad Sci U S A 115, E1069-E1074. Coruh, C., Cho, S.H., Shahid, S., Liu, Q., Wierzbicki, A., and Axtell, M.J. (2015). Comprehensive Annotation of Physcomitrella patens Small RNA Loci Reveals That the Heterochromatic Short Interfering RNA Pathway Is Largely Conserved in Land Plants. Plant Cell 27, 2148-2162. Liu, Q., and Axtell, M.J. (2015). Quantitating plant microRNA-mediated target repression using a dual-luciferase transient expression system. Methods Mol Biol 1284, 287-303. Brousse, C., Liu, Q., Beauclair, L., Deremetz, A., Axtell, M.J., and Bouche, N. (2014). A non-canonical plant microRNA target site. Nucleic Acids Res 42, 5270-5279. Liu, Q., Wang, F., and Axtell, M.J. (2014). Analysis of complementarity requirements for plant microRNA targeting using a Nicotiana benthamiana quantitative transient assay. Plant Cell 26, 741-753.