个人简介

1992-1998 Diploma Magister rer. nat, Chemistry, summa cum laude, University of Vienna, Austria (Advisor Dr.Dr. B.K. Keppler) 1998-2001 Ph.D., Chemistry, summa cum laude, J.-W.-G. University Frankfurt, Germany (Advisor Dr. C. Griesinger) 2001-8/2004 Research Associate, The Scripps Research Institute, USA (Advisor Dr. K. Wüthrich) 9/2004-6/2010 Assistant Professor, MPPB, Brown University, USA 7/2006-8/2010 MPP Graduate Program Director, Brown University, USA 7/2007-6/2010 Manning Assistant Professor, MPPB, Brown University, USA 7/2008-6/2010 Assistant Professor of Chemistry, Brown University, USA 7/2010-present Associate Professor (tenure) of Medical Science, Brown University, USA 7/2010-present Associate Professor (tenure) of Chemistry, Brown University, USA 7/2012-present Director Structural Biology Core Facility, Brown University, USA

研究领域

MAP kinases/NMR spectroscopy/PP1/biofilm/calcineurin/cancer/immunology

The focus of my research group is to understand the molecular mechanisms that regulates signalling enzymes. We combine the information derived from biomolecular NMR spectroscopy, X-ray crystallography, and additional biophysical techniques, such as ITC, DSC, Biacore, and CD spectroscopy. Enzymes of key interests are ser/thr protein phosphatases (PP1, PP2B), tyr phosphatases and ser/thr kinases, especially MAP Kinases. Furthermore, my research group is pursuing an molecular understanding for the formation of bacterial biofilms.

近期论文

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Lord, Dana M., Baran, Ayse Uzgoren, Wood, Thomas K., Peti, Wolfgang, Page, Rebecca. BdcA, a Protein Important for Escherichia coli Biofilm Dispersal, Is a Short-Chain Dehydrogenase/Reductase that Binds Specifically to NADPH PLoS ONE. 2014; 9 (9) : e105751 Francis DM, Koveal D, Tortajada A, Page R, Peti W. Interaction of kinase-interaction-motif protein tyrosine phosphatases with the mitogen-activated protein kinase ERK2. PLoS ONE. 2014; 9 (3) : e91934 Lord, Dana M., Uzgoren Baran, Ayse, Soo, Valerie W. C., Wood, Thomas K., Peti, Wolfgang, Page, Rebecca. McbR/YncC: Implications for the Mechanism of Ligand and DNA Binding by a Bacterial GntR Transcriptional Regulator Involved in Biofilm Formation Biochemistry. 2014; 53 (46) : 7223-7231 Francis DM, Page R, Peti W. Sequence-specific backbone ¹H, ¹³C and ¹⁵N assignments of the 34 kDa catalytic domain of PTPN5 (STEP). Biomolecular NMR assignments. 2014; 8 (1) : 185-8 Krishnan N, Koveal D, Miller DH, Xue B, Akshinthala SD, Kragelj J, Jensen MR, Gauss CM, Page R, Blackledge M, Muthuswamy SK, Peti W, Tonks NK. Targeting the disordered C terminus of PTP1B with an allosteric inhibitor. Nature chemical biology. 2014; 10 (7) : 558-66 Choy MS, Hieke M, Kumar GS, Lewis GR, Gonzalez-DeWhitt KR, Kessler RP, Stein BJ, Hessenberger M, Nairn AC, Peti W, Page R. Understanding the antagonism of retinoblastoma protein dephosphorylation by PNUTS provides insights into the PP1 regulatory code. Proc Natl Acad Sci USA. 2014; 111 (11) : 4097-102 Koveal D, Jayasundera TB, Wood TK, Peti W, Page R. Backbone and sidechain (1)H, (15)N and (13)C assignments of Tyrosine Phosphatase related to Biofilm formation A (TpbA) of Pseudomonas aeruginosa. Biomolecular NMR assignments. 2013; 7 (1) : 57-9 Peti W, Page R. Enzyme mechanisms: What's up 'Doc'? Nature chemical biology. 2013; 9 (12) : 756-7 Koveal D, Clarkson MW, Wood TK, Page R, Peti W. Ligand binding reduces conformational flexibility in the active site of tyrosine phosphatase related to biofilm formation A (TpbA) from Pseudomonasaeruginosa. Journal of molecular biology. 2013; 425 (12) : 2219-31 Peti W, Page R. Molecular basis of MAP kinase regulation. Protein science : a publication of the Protein Society. 2013; 22 (12) : 1698-710 Minnebo N, Görnemann J, O'Connell N, Van Dessel N, Derua R, Vermunt MW, Page R, Beullens M, Peti W, Van Eynde A, Bollen M. NIPP1 maintains EZH2 phosphorylation and promoter occupancy at proliferation-related target genes. Nucleic acids research. 2013; 41 (2) : 842-54 Peti W, Nairn AC, Page R. Structural basis for protein phosphatase 1 regulation and specificity. The FEBS journal. 2013; 280 (2) : 596-611 Kumar GS, Zettl H, Page R, Peti W. Structural basis for the regulation of the mitogen-activated protein (MAP) kinase p38α by the dual specificity phosphatase 16 MAP kinase binding domain in solution. The Journal of biological chemistry. 2013; 288 (39) : 28347-56 Brown BL, Lord DM, Grigoriu S, Peti W, Page R. The Escherichia coli toxin MqsR destabilizes the transcriptional repression complex formed between the antitoxin MqsA and the mqsRA operon promoter. The Journal of biological chemistry. 2013; 288 (2) : 1286-94 Francis DM, Kumar GS, Koveal D, Tortajada A, Page R, Peti W. The differential regulation of p38α by the neuronal kinase interaction motif protein tyrosine phosphatases, a detailed molecular study. Structure (London, England : 1993). 2013; 21 (9) : 1612-23 Grigoriu S, Bond R, Cossio P, Chen JA, Ly N, Hummer G, Page R, Cyert MS, Peti W. The molecular mechanism of substrate engagement and immunosuppressant inhibition of calcineurin. PLoS biology. 2013; 11 (2) : e1001492 Wang X, Lord DM, Hong SH, Peti W, Benedik MJ, Page R, Wood TK. Type II toxin/antitoxin MqsR/MqsA controls type V toxin/antitoxin GhoT/GhoS. Environmental microbiology. 2013; 15 (6) : 1734-44