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研究领域

1. 有机合成方法学: 发展重要杂环化合物的新合成方法,并应用在具有生理活性的天然产物的全合成中。 2. 药物化学: 合成具有生物活性的小分子库,进行新药和仿制药的研发

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20. Yue, D.; Yao, T.; Larock, R. C. “Synthesis of 1,2-Disubstituted 3-Iodoindoles via Palladium Catalyzed Coupling and Electrophilic Cyclization of Terminal Acetylenes”, J. Org. Chem. 2006, 71, 62. 19. Bao, Y.; Lantz, A. W.; Yao, T.; Huang, Q.; Larock, R. C.; Armstrong, D. W. “Enantiomeric separation of furan derivatives and fused polycycles by cyclodextrin-modified micellar capillary electrophoresis”, Electrophoresis 2005, 26, 4164. 18. Yue, D.; Yao, T.; Larock, R. C. “Synthesis of 2,3-Disubstituted Benzo[b]furans by the Palladium-Catalyzed Coupling of o-Iodoanisoles and Terminal Alkynes, Followed by Electrophilic Cyclization”, J. Org. Chem. 2005, 70, 10292. 17. Yao, T.; Yue, D.; Larock, R. C. “Solid-Phase Synthesis of 1,2,3-Trisubstituted Indoles and 2,3-Disubstituted Benzofurans via Iodocyclization”, J. Comb. Chem. 2005, 7, 809. 16. Yao, T.; Yue, D.; Larock, R. C. “An Efficient Synthesis of Coumestans by Iodocyclization and Pd-Catalyzed Intramolecular Lactonization”, J. Org. Chem. 2005, 70, 9985. 15. Yao, T.; Campo, M. A.; Larock, R. C. “Synthesis of Polycyclic Aromatics and Heteroaromatics via Electrophilic Cyclization”, J. Org. Chem. 2005, 70, 3511. 14. Yao, T.; Zhang, X.; Larock, R. C. “Synthesis of Highly Substituted Furans Through a AuCl3-Catalyzed or an Electrophile-Induced Cyclization of 2-(1-Alkynyl)-2-alken-1-ones with Nucleophiles ”, J. Org. Chem. 2005, 70, 7679. 13. Yao, T.; Larock, R. C. “A Regio- and Stereoselective Synthesis of Isoindolin-1-ones via Electrophilic Cyclization ”, J. Org. Chem. 2005, 70, 1432. 12. Zhang, X.; Campo, M. A.; Yao, T.; Larock, R. C. “Synthesis of Substituted Quinolines by Electrophilic Cyclization of N-(2-Alkynyl)anilines”, Org. Lett. 2005, 7, 763. 11. Yao, T.; Larock, R. C. “A Regio- and Stereoselective Synthesis of Isoindolin-1-ones via Electrophilic Cyclization ”, J. Org. Chem. 2005, 70, 1432. 10. Han, X.; Yao, T.; Liu, Y.; Armstrong, D. W.; Larock, R. C. “Separation of Furan Derivatives by Liquid Chromatography Using Cyclodextrin-Based Chiral Stationary Phases”, J. Chromatogr. A, 2005, 1063, 111. 9. Larock, R. C.; Wang, Y.; Dong, X.; Yao, T. “Synthesis of C-5 Substituted Nucleosides via Palladium-catalyzed Coupling of Dienes and Amines”, Tetrahedron, 2005, 61, 11427. 8. Huang, Q.; Campo, M. A.; Yao, T.; Tian, Q.; Larock, R. C. “Synthesis of Fused Polycycles by a 1,4-Palladium Shift”, J. Org. Chem. 2004, 69, 8251. 7. Yao, T.; Zhang, X.; Larock, R. C. “AuCl3-Catalyzed Synthesis of Highly Substituted Furans from 2-(1-Alkynyl)-2-alken-1-ones”, J. Am. Chem. Soc. 2004, 126, 11164. 6. Yao, T.; Campo, M. A.; Larock, R. C. “Synthesis of Polycyclic Aromatic Iodides via ICl-induced Intramolecular Cyclization”, Org. Lett. 2004, 6, 2677. 5. Campo, M. A.; Huang, Q.; Yao, T.; Tian, Q.; Larock, R. C. “1,4-Palladium Migration via C-H Activation, Followed by Arylation: Synthesis of Fused Polycycles”, J. Am. Chem. Soc. 2003, 125, 11506. 4. Yao, T.; Larock, R. C. “Synthesis of Isocoumarins and -Pyrones via Electrophilic Cyclization”, J. Org. Chem. 2003, 68, 5936. 3. Yao, T.; Larock, R. C. “Synthesis of Isocoumarins and -Pyrones via Iodocyclization”, Tetrahedron Lett. 2002, 43, 7401. 2. Liu, F.; Li, K.; Chen, W.; Wu, Y.; Yao, T.; Tong, S. “Preconcentration and Separation of Trace Pd(II) and Pt(IV) with Silica Gel Bonded by Aminopropylbenzoylazo-4-(2-pyridylazo)resorcinol”, Chin. J. Chem. 2000, 18, 537. 1. Yao, T; Jin, S.; Wang, C.; Ma, J. “Synthesis of C(10)-(4-Sulfonatophenyl)biliverdin Analogs”, Chem. J. Chin. Univ. 1998, 19, 1078.

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