Delaney, Sarah - Brown University - Department of Chemistry

个人简介

B.A. in Chemistry, Middlebury College (Advisor: Sunhee Choi) Ph.D. in Chemistry, Caltech (Advisor: Jacqueline K. Barton) Postdoctoral Fellow in Biological Engineering, MIT (Advisor: John M. Essigmann)

研究领域

The research in my laboratory aims to understand the biological consequences of DNA damage. Using the tools of chemistry and biology we probe the effects of DNA modification at the molecular level. We are particularly interested in the role of oxidative DNA damage and its contributions to cancer and neurological disorders such as Huntington's disease.

近期论文

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Schermerhorn, K. M. and Delaney, S. A chemical and kinetic perspective on base excision repair of DNA. Acc. Chem. Res. 2014, 47, 1238-1246. Volle C. B. and Delaney S. AGG/CCT interruptions affect nucleosome formation and positioning of healthy-length CGG/CCG triplet repeats. BMC Biochemistry. 2013, 14, 1-12. Schermerhorn, K. M. and Delaney, S. Transient-state kinetics of apurinic/apyrimidinic (AP) endonuclease 1 acting on an authentic AP site and commonly-used substrate analogs: The effect of diverse metal ions and base mismatches. Biochemistry. 2013, 52, 7669-7677. Volle, C. B. and Delaney, S. CAG/CTG repeats alter affinity for the histone core and positioning of DNA in the nucleosome. Biochemistry. 2012, 51, 9814-9825. Yennie, C. J. and Delaney, S. Thermodynamic consequences of the hyperoxidized guanine lesion guanidinohydantoin in duplex DNA. Chem. Res. Toxicol. 2012, 25, 1732-1739. Delaney, S., Jarem, D. A., Volle, C. B., and Yennie, C. J. Chemical and biological consequences of oxidatively damaged guanine in DNA. Free Rad. Res. 2012, 46, 420-441. Volle, C. B., Jarem, D. A., and Delaney, S.Trinucleotide repeat DNA alters structure to minimize the thermodynamic impact of 8-oxo-7,8-dihydroguanine. Biochemistry 2012, 51, 52-62. Jarem, D. A. and Delaney, S. Premutation huntingtin allele adopts a non-B conformation and contains a hot spot for DNA damage. Biochem. Biophys. Res. Comm. 2011, 416, 146-152. Avila Figueroa, A.; Cattie, D. J.; Delaney, S. A small unstructured nucleic acid disrupts a trinucleotide repeat hairpin. Biochem. Biophys. Res. Comm. 2011, 413, 532-536. Jarem, D. A.; Wilson, N. R.; Schermerhorn, K. M.; Delaney, S. Incidence and persistence of 8-oxo-7,8-dihydroguanine within a hairpin intermediate exacerbates a toxic oxidation cycle associated with trinucleotide repeat expansion. DNA Repair 2011, 10, 887-896. Cooper, D. C., Yennie, C. J., Morin, J. B., Delaney, S. , and Suggs, J. W. Development of a DNA-damaging ferrocene amino acid. J. Organomet. Chem. 2011, 696, 3058-3061. Avila Figueroa, A.; Cattie, D. J.; Delaney, S. Structure of even/odd trinucleotide repeat sequences modulates persistence of non-B conformations and conversion to duplex. Biochemistry 2011, 50, 4441-4450. Jarem, D. A.; Huckaby, L. V.; Delaney, S. AGG interruptions in (CGG)n DNA repeat tracts modulate the structure and thermodynamics of non-B conformations in vitro. Biochemistry 2010, 49, 6826-6837. Avila Figueroa, A.; Delaney, S. Mechanistic studies of hairpin to duplex conversion for trinucleotide repeat sequences. J. Biol. Chem. 2010, 285, 14648-14657. Jarem, D. A.; Wilson, N. R.; Delaney, S. Structure-dependent DNA damage and repair in a trinucleotide repeat sequence. Biochemistry 2009, 48, 6655-6663.