杨光 - 上海科技大学 - 免疫化学研究所

个人简介

Dr. Guang Yang finished his Ph.D. education at College Park, University of Maryland in 1995. Recently he won the Talent Award of Innovation and Entrepreneur of Jiangsu Province in 2012. He has a solid academic background, and has 20 years’ work experience in R&D department of global pharmaceutical companies and drug discovery institutes. The R&D team led by him obtained extraordinary achievements in the field of research and drugs discovery. He had established a wide range of cooperation with domestic and foreign partners.

研究领域

His research focus include phenotypic assay development and application; examination and characterization of therapeutic antibodies and their targets.; Dr. Guang Yang familiar with various disease areas, such as cancer, inflammatory, auto-immune, infectious, metabolic disorders, etc.

近期论文

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Yea K1, Zhang H, Xie J, Jones TM, Yang G, Song BD, Lerner RA. Converting stem cells to dendritic cells by agonist antibodies from unbiased morphogenic selections. Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):14966-71. Yang, G. & Bu, H.-Z.”Toxicology of Chiral Drugs”(2011) in “Chiral Drugs: Chemistry and Biological Action” Wiley, ISBN: 978-0-470-58720-1, Chapter 11. Pyridine-derived γ-secretase Modulators. Wan Z.; Hall A.; Sang Y.; Xiang JN.; Yang E.; Smith B.; Harrison DC.; Yang G.; Yu H.; Price HS.; Wang J.; Hawkins J.; Lau LF.; Johnson MR.; Li T.; Zhao W.; Mitchell WL.; Su X.; Zhang X.; Zhou Y.; Jin Y.; Tong Z.; Cheng Z.; Hussain I.; Elliott JD.; Matsuoka Y. Bioorg. Med. Chem. Lett. 2011; 21(16): 4832-5. Yang, G. & Bu, H.-Z. “Toxicology of Chiral Drugs” (2011) in “Chiral Drugs: Chemistry and Biological Action” Wiley, ISBN: 978-0-470-58720-1, Chapter 11. Combination of Virtual Screening and High Throughput Gene Profiling for Identification of LXR Modulators. Cheng, J.-F.; Zapf, J.; Takedomi, K.; Fukushima, C.; Ogiku, T.; Zhang, S.-H.; Yang, G.; Sakurai, N.; Barbosa, M.; Jack, R.; Xu, K. J. Med. Chem. 2008; 51(7): 2057-61. Highly Potent Inhibitors of Methionine Aminopeptidase-2 Based on a 1,2,4-Triazole Pharmacophore. Marino, J.P.; Fisher, P.W.; Hofmann, G.A.; Kirkpatrick, R.B.; Janson, C.A.; Johnson, R.K.; Ma, C.; Mattern, M.; Meek, T.D.; Ryan, M.D.; Schulz, C.; Smith, W.W.; Tew, D.G.; Tomazek, T.A.; Veber, D.F.; Xiong, W.C.; Yamamoto, Y.; Yamashita, K.; Yang, G.; Thompson, S.K. J. Med. Chem. 2007; 50(16): 3777-85.